HPLC profiling and studies on Copaifera salikounda methanol leaf extract on phenylhydrazine-induced hematotoxicity and oxidative stress in rats

Aloke, Chinyere; Emelike, Chinedum Uche; Obasi, Nwogo Ajuka; Ogbu, Patience Nkemjika; Edeogu, Chuks Oswald; Uzomba, Chinedu G.; Ekakitie, Ofovwe; Iyaniwura, Adeolu Adewale; Okoro, Chukwubuike Cyprian; Okey, Blessing Peter; Aninjoku, Glory Ginikachukwu; Ushahemba, Bature Charles

doi:10.1016/j.arabjc.2021.103428

Cited by 6 publications

(3 citation statements)

References 72 publications

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“…The administration of PHZ led equally to significant reductions in the activities of the enzymes SOD, CAT, and GPx [ 77 ]. In the present study, PHZ caused a significant increase in reactive radical NO levels, and these results are in line with Aloke et al [ 78 ], who showed that PHZ caused significant increases in MDA and NO levels as oxidative markers and significant decreases in SOD, CAT, and GSH as antioxidant markers. The excess production of NO causes DNA damage and inhibits DNA repair proteins [ 79 ].…”

Section: Discussionsupporting

confidence: 93%

The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

Khamis,

Diab,

Zahra

et al. 2023

Molecules

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Colon cancer is one of the most common types of cancer worldwide, and its incidence is increasing. Despite advances in medical science, the treatment of colon cancer still poses a significant challenge. This study aimed to investigate the potential protective effects of Adiantum pedatum (AP) extract and/or piceatannol on colon cancer induced via phenylhydrazine (PHZ) in terms of the antioxidant and apoptotic pathways and histopathologic changes in the colons of male albino rats. The rats were randomly divided into eight groups: control, AP extract, piceatannol (P), PHZ, PHZ and AP treatments, PHZ and P treatments, PHZ and both AP and P, and PHZ and prophylaxis with both AP and P. The results demonstrated that PHZ induced oxidative damage, apoptosis, and histopathological changes compared to the control group. However, the administration of AP or P or AP + P as therapy or prophylaxis significantly ameliorated these changes and upregulated the colonic mir-145 and mRNA expression of P53 and PDCD-4 while downregulating the colonic mRNA expression of PI3K, AKT, c-Myc, CK-20, SOX-2, OCT-4, and NanoG compared to the PHZ group. These findings suggest that the candidate drugs may exert their anti-cancer effects through multiple mechanisms, including antioxidant and apoptotic activities.

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Section: Discussionsupporting

confidence: 93%

The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

Khamis,

Diab,

Zahra

et al. 2023

Molecules

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“…The drug's capacity to trigger hemolysis is determined by how it interacts with RBCs. This reaction generates hydrogen peroxide and destroys the hemoglobin pigment by generating oxidized derivatives and hydrazine free radicals [34]. Because of its interaction with the plasma membrane, PHZ produces reactive oxygen species (ROS) in addition to lipid peroxidation and protein oxidation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of haematinic activity of <i>Tapinanthus globiferus</i> (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats

Asogwa,

Okolo,

Asogwa

et al. 2024

J. Pharm Bio.

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Anaemia is a leading cause of morbidity and mortality in both males and females of all ages. Anaemia was induced by intraperitoneal (i.p.) administration of phenylhydrazine (60 mg/kg) for a period of 3 days. Anaemic rats were allotted to five (5) groups; group I served as the negative control, group II served as the positive control received Astyfer syrup (0.15 mg/kg p.o) , groups III-V served as the test groups that received Tapinanthus globiferus methanol extract, ethyl acetate and n-hexane fractions (100, 200 and 400 mg/kg, p.o.), respectively. Packed cell volume (PCV), haemoglobin concentration (HB) and red blood cell count (RBC) were analysed as indices of anaemia at 7-day intervals for 21 days. The mean cell volume (MCV) and mean cell haemoglobin concentration (MCHC) were calculated accordingly. Leaf extract and fractions of Tapinanthus globiferus significantly (P<0.001) increased the PCV, the HB concentration and the RBC, which had been originally decreased by phenylhydrazine (P<0.001) administration within one week of treatment. The extract and fractions were compared with rats administered with the positive and vehicle-treated group. The results suggested that Tapinanthus globiferus leaves have haematinicactivities.

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“…The use of medicinal plants in the treatment and prevention of specific illnesses/ailments have demonstrated a vital role in the global healthcare system (Dasgupta and Bratati, 2007;Okoro et al, 2021;Ekakitie et al, 2021;Aloke et al, 2021a;Aloke et al, 2021b;Aloke et al, 2021c;Emelike et al, 2021). Phenolics have the capacity to scavenge free radicals resulting from their redox properties, commonly found in leaves, flowering tissues and woody parts such as stems and barks of plants (Larson, 1988).…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Modulation of antioxidant activities, markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by Combretum dolichopetalum

EMELIKE,

CHIJIOKE-AGU,

NWOKE

et al. 2023

Not Sci Biol

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Diabetes mellitus is a metabolic dysfunction of insulin secretion exhibiting hyperglycemia with abnormalities in protein, fat and carbohydrate metabolism. The present study aimed to investigate the effect of Combretum dolichopetalum (CD) on hepatic parameters, renal indices and antioxidant markers of alloxan-induced diabetic rats. Twenty (20) male rats were used, and they were divided into four groups of five rats each. Group 1- Normal control received distilled water (non-diabetic control); Group 2- Diabetic control received distilled water; Group 3 and Group 4 are Diabetic rats treated with 200 mg/kg and 400 mg/kg of CD extract. There were significant decreases in the final body weights of Group 2 compared with Group 1 and an elevation of the body weights of Groups 3 and 4 compared with Group 2. There were significant increases in the blood glucose concentration of Group 2 compared with Group 1 and a reduction in blood glucose concentration of Groups 3 and 4 compared with Group 2. There were increases in the alanine amino transaminase (ALT), alkaline phosphatase (ALP) activities and serum total and conjugated bilirubin levels of Groups 2 and 3 compared with Group 1, but a reduction in the ALP, ALT activities and total bilirubin in Group 4. There was an elevation in the superoxide dismutase (SOD) the activity of Group 4. There were reductions in catalase activities and no change in the renal indices. The study showed ameliorating potentials on hyperglycemia, hepatoprotective activity and antioxidation effects.

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HPLC profiling and studies on Copaifera salikounda methanol leaf extract on phenylhydrazine-induced hematotoxicity and oxidative stress in rats

Cited by 6 publications

References 72 publications

The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

Evaluation of haematinic activity of <i>Tapinanthus globiferus</i> (A. Rich.) van Tiegh leaf extract and fractions in phenylhydrazine-induced anaemic rats

Modulation of antioxidant activities, markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by Combretum dolichopetalum

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