HPLC/PDA/ESI-MS/MS analysis of chamomile decoction and mechanism of its protective effects on aspirin-induced small bowel injuries

Jabri, Mohamed-Amine; Hajji, Najla; Wannes, Dalanda; Tounsi, H.; Jridi, Mourad; Abdellaoui, Afifa; Marzouki, Lamjed; Sebaï, Hichem

doi:10.1039/c7ra07339a

Cited by 8 publications

(4 citation statements)

References 53 publications

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“…The CYP3A4 activity was inhibited ( p < 0.05) weakly by the other extracts tested, and it was not inhibited by the soy extract. According to the available literature, all extracts evaluated herein contain phenolic compounds. − The HPLC-UV analyses performed with the standardized medicinal plant extracts tested showed peaks in the UV spectra, confirming the presence of phenolic compounds (data not shown).…”

Section: Discussionmentioning

confidence: 65%

Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes

Feltrin

Farias

Sandjo

et al. 2020

Chem. Res. Toxicol.

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The use of medicinal plants concomitantly with conventional drugs can result in herb−drug interactions that cause fluctuations in drug bioavailability and consequent therapeutic failure and/or toxic effects. The CYP superfamily of enzymes plays an important role in herb−drug interactions. Among CYP enzymes, CYP3A4 and CYP2D6 are the most relevant since they metabolize about 50% and 30% of the drugs on the market, respectively. Thus, the main goal of this study was to evaluate the occurrence of in vitro interactions between medicinal plant extracts and drug substrates of CYP3A4 and CYP2D6 enzymes. Standardized extracts from nine medicinal plants (Bauhinia forficata, Cecropia glaziovii, Cimicif uga racemosa, Cynara scolymus, Echinacea sp., Ginkgo biloba, Glycine max, Ilex paraguariensis, and Matricaria recutita) were evaluated for their potential interactions mediated by CYP3A4 and CYP2D6 enzymes. Among the extracts tested, C. glaziovii (red embauba) showed the most relevant inhibitory effects of CYP3A4 and CYP2D6 activity, while I. paraguariensis (yerba mate) inhibited CYP3A4 activity. Both extracts were chemically analyzed by UPLC-MS/MS, and these inhibitory effects could lead to clinically potential and relevant interactions with the drug substrates of these isoenzymes.

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Section: Discussionmentioning

confidence: 65%

Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes

Feltrin

Farias

Sandjo

et al. 2020

Chem. Res. Toxicol.

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“…High resolution mass spectral data were obtained on a Thermo Instruments ESI‐MS system (Orbitrap Discovery LTQ XL/LTQ, UK) connected to a Thermo Instruments HPLC system (Accela PDA detector, Accela PDA autosampler and Accela pump). The identification of the compounds by LC/MS analysis is performed by comparing the retention times and the mass spectra of the unknown peaks with the controls . All samples were analyzed in three replicates.…”

Section: Methodsmentioning

confidence: 99%

Comparative Studies of Phytochemical Screening, HPLC‐PDA‐ESI‐MS/MS‐LC/HR‐ESI‐MS Analysis, Antioxidant Capacity andin VitroFermentation of Officinal Sage (Salvia officinalisL.) Cultivated in Different Biotopes of Northwestern Tunisia

Jedidi

Selmi

Aloui

et al. 2019

Chemistry & Biodiversity

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We aimed in the present study to investigate the chemical composition, the antioxidant capacities as well as the in vitro fermentation properties of Salvia officinalis leaves aqueous extract (SOLAE) grown in four regions of northwestern Tunisia. Our data firstly indicated a spatial variation (P < 0.05) in condensed tannins, total lipids, polyphenols and flavonoids contents. The HPLC-PDA-ESI-MS/MS-LC/HR-ESI-MS technique allowed to the identification of 13 phenolic compounds and showed that protocatechuic acid is the major constituent of the plant leaves grown in Tabarka, Ain Draham and Testour. The SOLAE of the plant grown in Tabarka presents the most potent scavenging activity against DPPH radical and had the highest percentage of inhibition. More importantly, we found in the present study that the digestibility of dry matter and in vitro fermentation showed a significant variation between the regions and the animal species. Also, we showed a very positive correlation between antioxidant properties and phenolic compounds contents. In conclusion, we suggest that SOLAE had potential beneficial effects owing in part to its antioxidant and ROS scavenging activities. Therefore, S. officinalis can be proposed as an additive food for animals' nutrition and health.

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“…High resolution mass spectral data were obtained on a Thermo Instruments ESI-MS system (LTQ XL/LTQ Orbitrap Discovery, UK) connected to a Thermo Instruments HPLC system (Accela PDA Detector, Accela PDA Autosampler and Accela Pump). 16…”

Section: Identication Of Distinctive Phenolic Compounds By Liquid Chmentioning

confidence: 99%

Modulating and opposite actions of two aqueous extracts prepared fromCinnamomum cassiaL. bark andQuercus ilexL. on the gastrointestinal tract in rats

et al. 2019

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HPLC/PDA/ESI-MS/MS analysis of chamomile decoction and mechanism of its protective effects on aspirin-induced small bowel injuries

Abstract: The aim of the present study is to evaluate the effect of chamomile (Matricaria recutitaL.) decoction extract (CDE) on aspirin-induced small bowel injuries.

Cited by 8 publications

References 53 publications

Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes

Effects of Standardized Medicinal Plant Extracts on Drug Metabolism Mediated by CYP3A4 and CYP2D6 Enzymes

Comparative Studies of Phytochemical Screening, HPLC‐PDA‐ESI‐MS/MS‐LC/HR‐ESI‐MS Analysis, Antioxidant Capacity andin VitroFermentation of Officinal Sage (Salvia officinalisL.) Cultivated in Different Biotopes of Northwestern Tunisia

Modulating and opposite actions of two aqueous extracts prepared fromCinnamomum cassiaL. bark andQuercus ilexL. on the gastrointestinal tract in rats

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