HPLC-MS/MS method for the determination of perfluoroalkyl substances in breast milk by combining salt-assisted and dispersive liquid-liquid microextraction

Vela-Soria, Fernando; Serrano-López, Laura; Garcia-Villanova, J; Haro, Tomás de; Olea, Nicolás; Freire, Carmen

doi:10.1007/s00216-020-02924-x

Cited by 7 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SMPE procedure requires preparation of the solid sorbent and subsequently analysis of the prepared sorbent by analytical instrument, which is time consuming and costly. The DLLME procedures are easy, rapid, and also require no extra characterization 20 , 21 . However, the use of toxic solvents (solvents used as extractant and disperser) is the main drawback of this method.…”

Section: Introductionmentioning

confidence: 99%

Solidified floating organic droplet microextraction coupled with HPLC for rapid determination of trans, trans muconic acid in benzene biomonitoring

Dehghani

Omidi

Heravizadeh

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Benzene is one of the carcinogenic compounds in the work environments. Exposure assessment of benzene through biological monitoring is an acceptable way to accurately measure the real exposure in order to conducting the health risk assessment, but it is always complicated, laborious, time consuming and costly process. A new sensitive, simple, fast and environmental friendly method was developed for the determination of urinary metabolite of benzene, trans trans muconic acid (t,t-MA) by dispersive liquid–liquid micro extraction based on solidification of floating organic droplet coupled with high-performance liquid chromatography with ultra violet detector. Central composite design methodology was utilized to evaluate the effective factors on the extraction output of the target metabolite. The calibration curve was plotted in the concentration ranges of 0.02–5 µg mL−1. The precision and accuracy of the method were assayed via the relative standard deviation (RSD%) and relative recovery (RR%) using spiked samples with three replications. The RR% and RSD% of the optimized method were 86.9–91.3% and 4.3–6.3% respectively. The limit of detection (LOD) of the method was 0.006 µg mL−1. The level of t,t-MA in real samples was ranged from 0.54 to 1.64 mg/g creatinine. We demonstrated that t,t-MA can be extracted and determined by an inexpensive, simple and fast method.

show abstract

Section: Introductionmentioning

confidence: 99%