HPLC–MS analyses and bioactivities of novel chemicals in Devil’s club (Oplopanax horridus (Sm.) Miq.)

You, Qidong; Chen, Feng; Ni, Hui; Wang, Xi; Jiang, Yueming; McCoy, Joe-Ann

doi:10.1016/j.foodchem.2012.04.067

Cited by 4 publications

(5 citation statements)

References 26 publications

(23 reference statements)

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“…Miq. (You et al, ). The ranking of TFC values of the D. rupestre extracts was in the same order as TPC, and the highest TFC was found in EAF at 426.70 mg RE/g which was 13‐fold than WF.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl₄ -induced hepatotoxicity in Kunming mice

et al. 2017

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The current study evaluated antioxidant activity of Dracocephalum rupestre Hance, characterized by the polyphenolic compounds in the ethyl acetate fraction (EAF) from D. rupestre and investigated the protective mechanisms of EAF in carbon tetrachloride (CCl 4 )-induced hepatic injury. EAF showed the largest antioxidant capacity as demonstrated by DPPH, ABTS, OH, and FRAP assays J Food Biochem. 2018;42:e12484.

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“…Miq. (You et al, ). The ranking of TFC values of the D. rupestre extracts was in the same order as TPC, and the highest TFC was found in EAF at 426.70 mg RE/g which was 13‐fold than WF.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl₄ -induced hepatotoxicity in Kunming mice

et al. 2017

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“…In past decades, a few polyynes and phenolics were discovered in both O. horridus and O. elatus , which were reported to display antioxidant activity . Meanwhile, the antioxidant capacity of O. horridus was assayed in terms of the determination of total phenolic content, oxygen radical absorbance capacity and DPPH free radical scavenging activity, which showed that approximate 85% of the DPPH free radicals could be scavenged by the methanol extract of the root of O. horridus at the concentration of 2.8 mg/mL . In comparison, the methanol extract of the root of O. elatus showed better capacity to scavenge the same free radicals as O. horridus at the concentration of 758.6 μg/mL.…”

Section: Resultsmentioning

confidence: 99%

“…The DPPH free radical scavenging activity of extract from the root of O. elatus was carried out according to the method described in the literature . Briefly, 25 μL of sample (4.0 mg/mL) was mixed with 40 μL of DPPH methanol solution (0.4 mg/mL), and then the mixture was made up with methanol to a final volume of 250 μL.…”

Section: Methodsmentioning

confidence: 99%

Screening and identifying antioxidants from Oplopanax elatus using 2,2ʹ‐diphenyl‐1‐picrylhydrazyl with off‐line two‐dimensional HPLC coupled with diode array detection and tandem time‐of‐flight mass spectrometry

Shao

Nie

Chen

et al. 2016

J of Separation Science

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The root of Oplopanax elatus (Nakai) Nakai has a well-known history of use for the treatment of diseases such as neurasthenia, cardiovascular disorders, and cancer by the native people in northeast China. It is important to screen and identify the bioactive molecules from its root rapidly. Hereby, an off-line two-dimensional high performance liquid chromatography coupled with diode array detection and tandem time-of-flight mass spectrometry together with 2,2'-diphenyl-1-picrylhydrazyl was established to screen antioxidants from the root of O. elatus. A Waters cyanogen column (150 × 3.9 mm, id, 4 μm) was used for the first dimensional liquid chromatography, while a Hypersil BDS-C18 column (250 × 4.6 mm, id, 5 μm) was installed for the second dimension liquid chromatographic analysis. Twenty-eight compounds had been tentatively identified from the methanol extract of the air-dried root of O. elatus including six polyynes and eight phenolic derivatives were screened with antioxidant activity. The developed method could be expedient for screening and identifying antioxidants from O. elatus.

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“…1J) containing phytochemicals found in C. intybus. It was demonstrated to scavenge oxygen radical absorbance capacity (ORAC) and DPPH radical in an in vitro experiment (69).…”

Section: -Hydroxy-3-methoxyphenyl 4-o-feruloylquinic Acid Ismentioning

confidence: 99%

“…Miq. exhibited anti-proliferative effects against human colon adenocarcinoma cells (HT-29; 56.5% inhibition with a 0.2 mg/ml extract)(69). Chicoric acid, in synergy with luteolin was found to act as an anti-oxidant and anti-inflammatory agent in mouse macrophage cells (RAW 264.7; luteolin:chicoric acid =1:1, 1:2, 1:4 where IC 50 of luteolin was 11.6, 9.8 and 9.8 µM, respectively) (70).…”

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confidence: 99%

Cytotoxicity of Cichorium intybus L. metabolites (Review)

et al. 2019

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Cichorium intybus L. (Chicory) is a widely distributed, edible, perennial, herbaceous member of the Asteraceae family. Besides its use in modern Chinese herbal medicine, its ethnomedicinal use is evident in the text from ancient Greece, Egypt and China. It is also used as a food and coffee substitute, which is mainly responsible for its extensive domestication. In recent decades, cytotoxic studies of C. intybus extracts have shown its antitumor potential. These studies also identified metabolite constituents including guaianolides, 6-methoxyflavone, eudesmanolides, germacranolides, polyacetylene, sterol, anthocyanin, delphinidin, 3,4-dihydroxyphenethyl and other novel compounds. Many of these phytometabolites have shown positive cytotoxic activities in vitro, and antitumor action in vivo and in clinical trials, demonstrating the potential of C. intybus metabolites as antitumor drugs. Structural activity relationship studies have further confirmed these bioactivities. In this review, we focused on the phytochemicals of C. intybus with reported cytotoxicity and potential antitumor properties. We also discuss their specificity towards tumor cells, structural activity relationship, the involved signaling pathways and molecular mechanism, with the expectation of the future development of efficient and targeted antitumor therapeutic strategies.

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HPLC–MS analyses and bioactivities of novel chemicals in Devil’s club (Oplopanax horridus (Sm.) Miq.)

Cited by 4 publications

References 26 publications

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl₄ -induced hepatotoxicity in Kunming mice

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl₄ -induced hepatotoxicity in Kunming mice

Screening and identifying antioxidants from Oplopanax elatus using 2,2ʹ‐diphenyl‐1‐picrylhydrazyl with off‐line two‐dimensional HPLC coupled with diode array detection and tandem time‐of‐flight mass spectrometry

Cytotoxicity of Cichorium intybus L. metabolites (Review)

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HPLC–MS analyses and bioactivities of novel chemicals in Devil’s club (Oplopanax horridus (Sm.) Miq.)

Cited by 4 publications

References 26 publications

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl4 -induced hepatotoxicity in Kunming mice

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl4 -induced hepatotoxicity in Kunming mice

Screening and identifying antioxidants from Oplopanax elatus using 2,2ʹ‐diphenyl‐1‐picrylhydrazyl with off‐line two‐dimensional HPLC coupled with diode array detection and tandem time‐of‐flight mass spectrometry

Cytotoxicity of Cichorium intybus L. metabolites (Review)

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Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl₄ -induced hepatotoxicity in Kunming mice

Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl₄ -induced hepatotoxicity in Kunming mice