HPLC method for the determination of the S- and R-diastereomers of telaprevir for treatment of patients with hepatitis C

Heinz, Werner; Kuschak, Dieter; Schirmer, Diana; Grau, Anna; Keller, Daniela; Klinker, Hartwig

doi:10.1515/labmed-2015-0001

Cited by 60 publications

(93 citation statements)

References 13 publications

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“…For many years it has been known that both AGN and Galactic BHs follow this empirical relation (Merloni et al 2003), which is a correlation between radio luminosity at 5 GHz, X-ray luminosity in the range 2-10 keV, and BH mass. The physics underlying the FP is the nonlinear scalability between accretion, jet power, and BH mass (Heinz & Sunyaev 2003), which is fundamental in the unification of relativistic jets (Foschini 2014). When projected, the FP can be expressed as…”

Section: γ-Nls1s On the Fundamental Planementioning

confidence: 99%

Broadband X-ray observations of four gamma-ray narrow-line Seyfert 1 galaxies

Berton

Braito

Mathur

et al. 2019

A&A

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Narrow-line Seyfert 1 galaxies (NLS1s) is one of the few classes of active galactic nuclei (AGN) harboring powerful relativistic jets and detected in γ rays. NLS1s are well-known X-ray sources. While in non-jetted sources the origin of this X-ray emission may be a hot corona surrounding the accretion disk, in jetted objects, especially beamed ones, the contribution of corona and relativistic jet is difficult to disentangle without a proper sampling of the hard X-ray emission. For this reason, we observed with NuSTAR the first four NLS1s detected at high energy γ rays. These data, along with XMM-Newton and Swift/XRT observations, confirmed that X rays originate both in the jet and in the accretion disk corona. Time variability in hard X rays furthermore suggests that, as observed in flat-spectrum radio quasars, the dissipation region during flares could change its position from source to source, and it can be located both inside and outside the broad-line region. We find that jetted NLS1s, and other blazars as well, seem not to follow the classical fundamental plane of BH activity, which therefore should be used as a BH mass estimator in blazars with extreme care only. Our results strengthen the idea according to which γ-NLS1s are smaller and younger version of flat-spectrum radio quasars, in which both a Seyfert and a blazar component co-exist.

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Section: γ-Nls1s On the Fundamental Planementioning

confidence: 99%

Broadband X-ray observations of four gamma-ray narrow-line Seyfert 1 galaxies

Berton

Braito

Mathur

et al. 2019

A&A

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“…One advantage of this interpretation is that it is based on the truncated accretion-jet model (Esin et al 1997;Yuan & Narayan 2014), which has been successfully applied to the hard state of BHBs. In this model, the synchrotron radio emission from a jet follows L R ∝Ṁ ∼1.4 jet (Heinz & Sunyaev 2003), whereṀ jet the mass loss rate into the jet. If the X-ray emission from hot accretion flow scales with mass accretion rateṀ as L X ∝Ṁ k (parameter k characters the radiative efficiency in X-rays) andṀ jet ∝Ṁ , then we have L R ∝ L ∼1.4/k X (Heinz & Sunyaev 2003;Coriat et al 2011). In this picture, different slope in RX correlation is due to the difference in k, i.e.…”

Section: Theoretical Interpretation Of Radio/x-ray Correlationmentioning

confidence: 99%

“…In this model, the synchrotron radio emission from a jet follows L R ∝Ṁ ∼1.4 jet (Heinz & Sunyaev 2003), whereṀ jet the mass loss rate into the jet. If the X-ray emission from hot accretion flow scales with mass accretion rateṀ as L X ∝Ṁ k (parameter k characters the radiative efficiency in X-rays) andṀ jet ∝Ṁ , then we have L R ∝ L ∼1.4/k X (Heinz & Sunyaev 2003;Coriat et al 2011). In this picture, different slope in RX correlation is due to the difference in k, i.e. standard one has k ≈ 2.2 (Esin et al 1997;Merloni et al 2003), flat p ∼ 0 one has k 1, and p ≈ 1.3 has k ≈ 1.…”

Section: Theoretical Interpretation Of Radio/x-ray Correlationmentioning

confidence: 99%

“…Physically, the standard RX correlation provides strong evidence for a tight connection between the hot X-ray emitting source (usually a hot accretion flow), and the radio 2 A slight offset in the normalization among the full and failed (defined as the case of no transition into the soft state) outbursts are observed in GX 339-4 (Fürst et al 2015). 3 Quiescent BHBs seem to follow the standard RX correlation Plotkin et al 2017), maybe because they are still not dim enough in these observations (e.g., discussions in Xie & Yuan 2017, and a hint in Dincer et al 2018). source (usually a continuous jet), and it is understood under the coupled accretion-jet model, where a scale-invariant jet model is considered (e.g., Heinz & Sunyaev 2003;Merloni et al 2003;Heinz 2004;Yuan & Cui 2005;Xie & Yuan 2016). The physics behind the hybrid RX correlation, as well as its connection to the standard one, on the other hand, remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Radio/X-Ray Correlation in the Mini-outbursts of Black Hole X-Ray Transient GRS 1739–278

Xie

Yan

2020

ApJ

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We present quasi-simultaneous radio and X-ray observations of the black hole X-ray binary GRS 1739-278 of its 2015-2016 mini-outbursts, i.e. between 2015 June 10 and 2016 October 31, with the X-ray-to-radio time interval being less than one day. The monitor campaign was run by Swift in the X-rays and by JVLA in the radio (at both 5 GHz and 8 GHz). We find that the brightest radio emission is actually achieved during the soft sate, and the spectrum is marginally optically-thick with the spectral index α ≈ −0.28 ± 0.17 (flux F ν ∝ ν α ). For the radio emission in the hard state, we find a large diversity in the spectral index, i.e. a majority of radio spectra are optically-thick with −0.5 α 0.5, while a few are optically-thin, with α being lower than −1 in certain cases. We then investigate the correlation between the luminosities in radio (monochromatic at 5 GHz, L R ) and 1-10 keV X-rays (L X ) during the hard state. We find that for more than two orders of magnitude variation in the X-ray luminosity, this source exhibits a flat correlation with p ≈ 0.16 (in the form of L R ∝ L p X ), i.e. it belongs to the "outlier" (to the standard correlation with p ≈ 0.6) category that may follow a hybrid correlation. Both the slope and the corresponding luminosity range agree well with those in H1743-322, the prototype of the hybrid correlation. Theoretical implications of our results are discussed.

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“…The power and luminosity of relativistic jets depend on the black hole mass and follow a non-linear scaling relation. Therefore, low-mass AGN will inevitably harbor less powerful jets (Heinz & Sunyaev 2003;Foschini 2014). Since the scaling weighs more on the radio luminosity than in the optical, the radio-loudness criterion can become inadequate in low-mass sources.…”

Section: Introductionmentioning

confidence: 99%

Absorbed relativistic jets in radio-quiet narrow-line Seyfert 1 galaxies

Berton

Järvelä

Crepaldi

et al. 2020

A&A

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Narrow-line Seyfert 1 (NLS1) galaxies are peculiar active galactic nuclei (AGN). Most of them do not show strong radio emission, but recently seven radio-quiet (or -silent) NLS1s have been detected flaring multiple times at 37 GHz by the Metsähovi Radio Telescope, indicating the presence of relativistic jets in these peculiar sources. We observed them with the Karl G. Jansky Very Large Array (JVLA) in A configuration at 1.6, 5.2, and 9.0 GHz. Our results show that these sources are either extremely faint or not detected in the JVLA bands. At those frequencies, the radio emission from their relativistic jet must be absorbed, either via synchrotron selfabsorption as it occurs in gigahertz-peaked sources or, more likely, via free-free absorption by a screen of ionized gas associated with starburst activity or shocks. Our findings cast new shadows on the radio-loudness criterion, which seems to be more and more frequently a misleading parameter. New high-frequency and high-resolution radio observations are essential to test our hypotheses.

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HPLC method for the determination of the S- and R-diastereomers of telaprevir for treatment of patients with hepatitis C

Cited by 60 publications

References 13 publications

Broadband X-ray observations of four gamma-ray narrow-line Seyfert 1 galaxies

Broadband X-ray observations of four gamma-ray narrow-line Seyfert 1 galaxies

Radio/X-Ray Correlation in the Mini-outbursts of Black Hole X-Ray Transient GRS 1739–278

Absorbed relativistic jets in radio-quiet narrow-line Seyfert 1 galaxies

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