HPLC analysis ofArtemisia dracunculus extracts

Onuchak, L. A.; Куркин, В. А.; Minakhmetov, R. A.; Куркина, А. В.

doi:10.1007/bf02236417

Cited by 8 publications

(5 citation statements)

References 1 publication

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“…' Colletrotichum gloeosporioides, and Colletrotichum acutatum. 42,54 This provides a basis for possibly developing A. dracunculus preparations for use against agricultural pathogenic fungi.…”

Section: ' Use In Local and Traditional Medicinementioning

confidence: 99%

“…A. dracunculus essential oil has been reported to possess moderate antifungal activity against a number of species including Phythium ultimum, Sclerotinia sclerotiorum, Botrytis sp., Fusarium seminectum, Colletrotichum fragariae, Colletrotichum gloeosporioides, and Colletrotichum acutatum. 42,54 This provides a basis for possibly developing A. dracunculus preparations for use against agricultural pathogenic fungi.…”

Section: ' In Vitro Pharmacological Activities Of Tarragonmentioning

confidence: 99%

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Artemisia dracunculus L. (Tarragon): A Critical Review of Its Traditional Use, Chemical Composition, Pharmacology, and Safety

Obolskiy

Pischel

Feistel³

et al. 2011

J. Agric. Food Chem.

165

176

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Artemisia dracunculus L. (tarragon) has a long history of use as a spice and remedy. Two well-described "cultivars" (Russian and French) are used widely and differ in ploidy level, morphology, and chemistry. Key biologically active secondary metabolites are essential oils (0.15-3.1%), coumarins (>1%), flavonoids, and phenolcarbonic acids. In vivo studies mainly in rodents, particularly from Russian sources, highlight potential anti-inflammatory, hepatoprotective, and antihyperglycemic effects. Despite concerns about the toxic effects of two of its main constituents, estragole (up to 82%) and methyleugenol (up to 39%), no acute toxicity or mutagenic activity has been reported at doses relevant for human consumption. Water extracts of A. dracunculus contain very low amounts of estragole and methyleugenol and, therefore, are considered to pose a very limited risk. Overall, a stronger focus on clinical studies and precise taxonomic and phytochemical definition of the source material will be essential for future research efforts.

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Section: ' Use In Local and Traditional Medicinementioning

confidence: 99%

Section: ' In Vitro Pharmacological Activities Of Tarragonmentioning

confidence: 99%

Artemisia dracunculus L. (Tarragon): A Critical Review of Its Traditional Use, Chemical Composition, Pharmacology, and Safety

Obolskiy

Pischel

Feistel³

et al. 2011

J. Agric. Food Chem.

165

176

View full text Add to dashboard Cite

show abstract

“…A number of studies [20,25,26] presented more detailed analyses of the flavonoid compositions of the above-ground parts of tarragon, Gribovskii variety, cultivated in the Samara area. Three flavonoid compounds were extracted and identified.…”

Section: Flavonoidsmentioning

confidence: 99%

Biological characteristics and useful properties of tarragon (Artemisia dracunculus L.) (review)

2008

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This review systematizes published data on the chemical composition, biological activities, and uses of the above-ground part of tarragon (Artemisia dracunculus L., Asteraceae family). Analysis of the pharmacological properties of tarragon showed that the most interesting items from the medicinal point of view were its abilities to influence brain function and gastrointestinal tract function and the presence of a broad spectrum of antimicrobial activity. The complexity and variety of the chemical composition of tarragon generates the needs to identify the main groups of biologically active substances, to specify the main measures of quality and raw material standardization methods, and to perform further pharmacological studies with the aim of developing new tarragon-based medicinal agents.

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“…Pinocembrin (5,7-dihydroxyflavanone) (25) is the main component of flavonoid extracts of licorice (Glycyrrhiza glabra L.) (26,27) and tarragon wormwood (Artemisia dracunculus L.) (28). It is also one of the principal bioactive components of propolis (29).…”

Section: Introductionmentioning

confidence: 99%

Effect of pinocembrin on thymocyte proliferation and death

Toshtemirova,

Rustamova,

Tsiferova

et al. 2024

J Herbmed Pharmacol

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Introduction: Cell volume regulation is critical for cellular proliferation and death. Pinocembrin effectively suppresses the volume regulation in thymocytes under hypoosmotic stress by blocking the volume-sensitive anion channel. This study aims to evaluate the effects of this flavonoid on thymocyte proliferation and death. Methods: Thymocytes were cultured in RPMI-1640 medium supplemented with 10% fetal bovine serum, and the cell number was determined by cloud-based automated cell counting (Corning). Necrotic and apoptotic cell death were evaluated by propidium iodide- and annexin V-staining, respectively. Results: Pinocembrin at 10–50 μM caused suppression of primary cultured thymocyte proliferation with a half-maximal effect of 28.4 ± 0.2 μM. The cell counts did not fall below the control level at the doses of 100–150 μM. The fraction of spontaneously necrotic cells was ~26% of the total population and increased to ~51% in the presence of dexamethasone. The fraction of spontaneously apoptotic cells increased by this glucocorticoid from 3.6% to 16.7%. Pinocembrin protected thymocytes from necrosis both in spontaneous and dexamethasone-induced death, reducing the fraction of necrotic cells by ~40–50% at 150 μM. Pinocembrin attenuated dexamethasone-induced apoptotic death, reducing the fraction of annexin-positive cells to the control (spontaneous) level. Conclusion: Our results suggest that pinocembrin arrests thymocyte proliferation without essential killing. Under conditions of massive death (e.g., during inflammation, when the level of glucocorticoids increases sharply both physiologically and as a result of pharmacotherapy), pinocembrin protects immuno-competent cells from necrotic and apoptotic death.

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HPLC analysis ofArtemisia dracunculus extracts

Cited by 8 publications

References 1 publication

Artemisia dracunculus L. (Tarragon): A Critical Review of Its Traditional Use, Chemical Composition, Pharmacology, and Safety

Artemisia dracunculus L. (Tarragon): A Critical Review of Its Traditional Use, Chemical Composition, Pharmacology, and Safety

Biological characteristics and useful properties of tarragon (Artemisia dracunculus L.) (review)

Effect of pinocembrin on thymocyte proliferation and death

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