HPeV3-associated acute encephalitis/encephalopathy among Japanese infants

Abe, Yuichi; Ohno, Takuro; Matsumoto, Hiroshi; Daimon, Yusuke; Kurahashi, Hirokazu; Takayama, Rumiko; Sakaguchi, Yoshihisa; Tanabe, Saori; Tanaka, Fumiko; Miyamoto, Yusaku; Kawano, Akiko; Yamanouchi, Hideo

doi:10.1016/j.braindev.2020.12.010

Cited by 7 publications

(18 citation statements)

References 22 publications

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“…Incidence of HPeV meningitis in the Asian continent has been studied mainly in Japan and Korea [ 27 – 34 ]. A multicentre study, conducted in Japan identified 240 infants with HPeV type 3 infection, of which 14.2% diagnosed with acute CNS infection [ 28 ]. Among 216 patients aged less than 4 months and hospitalised for fever, 110 were found to have a viral infection on serum or CSF, caused by HPeV in 60 cases [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Human parechovirus meningitis in children: state of the art

Bozzola,

Barni,

Barone

et al. 2023

Ital J Pediatr

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Human Parechovirus is a common cause of infection occurring especially during the first years of life. It may present with a broad spectrum of manifestations, ranging from a pauci-symptomatic infection to a sepsis-like or central nervous system disease. Aim of this study is to explore the knowledge on Parechovirus meningitis. According to the purpose of the study, a systematic review of the literature focusing on reports on central nervous system. Parechovirus infection of children was performed following PRISMA criteria. Out of the search, 304 papers were identified and 81 records were included in the revision dealing with epidemiology, clinical manifestations, laboratory findings, imaging, therapy and outcome. Parechovirus meningitis incidence may vary all over the world and outbreaks may occur. Fever is the most common symptom, followed by other non-specific signs and symptoms including irritability, poor feeding, skin rash or seizures. Although several reports describe favourable short-term neurodevelopmental outcomes at discharge after Parechovirus central nervous system infection, a specific follow up and the awareness on the risk of sequelae should be underlined in relation to the reported negative outcome. Evidence seems to suggest a correlation between magnetic imaging resonance alteration and a poor outcome.

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Section: Discussionmentioning

confidence: 99%

“…Of 81 reports analysed, 47 dealt with the clinical presentation of HPeV meningeal infection [ 1 , 8 – 12 , 14 , 17 , 21 , 23 , 25 – 28 , 32 , 33 , 41 , 44 – 73 ].…”

Section: Discussionmentioning

confidence: 99%

Human parechovirus meningitis in children: state of the art

Bozzola,

Barni,

Barone

et al. 2023

Ital J Pediatr

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show abstract

“…9 In a case series from Japan, of 17 neonates with HPeV encephalitis who had abnormal neuroimaging, 4 had developmental abnormalities identified at follow-up; however, there was no correlation between MRI severity and developmental outcomes. 10 In experimental cell-culture and animal models, neuronal damage from HPeV3 resulted from infection-induced interferon and cytokine expression as confirmed by RT-PCR in the affected neurons with resultant increased expression of cell-death cytokines (as confirmed by Western blot) leading to activation of apoptosis, autophagy, and pyroptosis, though the full mechanism of HPeV3 pathogenesis is still being investigated. 13 Infection with HPeV, particularly serotype HPeV3, should be considered in any infant less than 3 months of age presenting with sepsis and signs of meningoencephalitis and/or seizures.…”

Section: Denouementmentioning

confidence: 98%

“…Importantly, in contrast to neonatal EV, these infants with HPeV meningoencephalitis typically have no CSF pleocytosis, though they may have elevated CSF protein. 1,5,9,10…”

Section: Denouementmentioning

confidence: 99%

“…Importantly, in contrast to neonatal EV, these infants with HPeV meningoencephalitis typically have no CSF pleocytosis, though they may have elevated CSF protein. 1,5,9,10 There are no proven treatment options for infections with HPeV, and supportive care is the mainstay of management. intravenous immune globulin (IVIG) has been used anecdotally, though there have been no randomized controlled trials.…”

Section: Denouementmentioning

confidence: 99%

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