HP-Xe to go: Storage and transportation of hyperpolarized 129Xenon

Repetto, M.; Zimmer, S.; Allmendinger, F.; Blümler, Peter; Doll, Monica Pacheco; Grasdijk, Jan; Heil, W.; Jungmann, Klaus-Peter; Karpuk, S.; Krause, Hans‐Joachim; Offenhäusser, Andreas; Schmidt, Ulrich; Sobolev, Yu.; Willmann, Lorenz

doi:10.1016/j.jmr.2016.02.011

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…The longitudinal relaxation rate 1/T 1,Xe can be decomposed according to 1/T 1,Xe = 1/T 1,wall +1/T 1,vdW . These terms in turn can be determined from independent measurements published in [23,24], where the same sample cell was used. For the wall relaxation times of 129 Xe, values between 17 h < T 1,wall < 20 h were found which together with the expected relaxation time via Xe-Xe van der Waals (vdW) dimers,…”

Section: Resultsmentioning

confidence: 99%

Precise measurement of magnetic field gradients from free spin precession signals of 3He and 129Xe magnetometers

et al. 2017

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We report on precise measurements of magnetic field gradients extracted from transverse relaxation rates of precessing spin samples. The experimental approach is based on the free precession of gaseous, nuclear spin polarized 3 He and 129 Xe atoms in a spherical cell inside a magnetic guiding field of about 400 nT using LTC SQUIDs as low-noise magnetic flux detectors. The transverse relaxation rates of both spin species are simultaneously monitored as magnetic field gradients are varied. For transverse relaxation times reaching 100 h, the residual longitudinal field gradient across the spin sample could be deduced to be|∇Bz| = (5.6 ± 0.4) pT/cm. The method takes advantage of the high signal-to-noise ratio with which the decaying spin precession signal can be monitored that finally leads to the exceptional accuracy to determine magnetic field gradients at the sub pT/cm scale.

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Section: Resultsmentioning

confidence: 99%

Precise measurement of magnetic field gradients from free spin precession signals of 3He and 129Xe magnetometers

et al. 2017

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“…Thus the optical polarization equipment does not need to be at the same facility as the NMR experiments, opening up the prospect of a central facility for production and shipping of highly polarized crystals, 49 as has been demonstrated for hyperpolarized Xe and dissolution DNP solutions. 50,51 While the experiments in this work focused on small molecules, we anticipate that the method can be applied more generally. Current efforts are directed to applying the approach to further systems of interest in the areas of pharmaceutical screening, quality assurance, complex mixture analysis, and structural biochemistry.…”

Section: Discussionmentioning

confidence: 99%

Hyperpolarized solution-state NMR spectroscopy with optically polarized crystals

Eichhorn¹,

Parker²,

Josten³

et al. 2021

Preprint

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Nuclear spin hyperpolarization provides a promising route to overcome the challenges imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that dissolution of spin-polarized pentacene-doped naphthalene crystals enables transfer of polarization to target molecules via intermolecular cross relaxation at room temperature and moderate magnetic fields (1.45 T). This makes it possible to exploit the high spin polarization of optically polarized crystals while mitigating the challenges of its transfer to external nuclei, particularly of the large distances and prohibitively weak coupling between source and target nuclei across solid-solid or solid-liquid interfaces. With this method, here we inject the highly polarized mixture into a benchtop NMR spectrometer and observe the polarization dynamics for target 1 H nuclei. Although the spectra are radiation damped due to the high naphthalene magnetization, we describe a procedure to process the data in order to obtain more conventional NMR spectra, and extract the target nuclei polarization. With the entire process occurring on a timescale of one minute, we observe NMR signals enhanced by factors between -200 and -1730 at 1.45 T for a range of small molecules.

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“…Чтобы сохранить ядерную поляризацию замороженного ксенона в процессе хранения и накопления, необходимо поддерживать его в достаточно сильном магнитном поле, порядка сотен mT [50]. В работах [51,52] Один из перспективных вариантов системы криохранения, существенно (до 50%) уменьшающий потери поляризации 129 Xe, показан на рис.…”

Section: хранение и транспортировкаunclassified

Методы Получения Поляризованного Ксенона Для Магнитно-Резонансной Томографии (Обзор)

Григорьев¹,

Лагутин²

2022

Журнал Технической Физики

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A review of experimental studies and design developments of devices for obtaining nuclear-spin hyperpolarized 129Xe by optical pumping of rubidium vapor with subsequent spin exchange with noble gas isotope atoms is presented. Hyperpolarized 129Xe atom is an excellent probe in magnetic resonance imaging in studies of lung structure and function, and biomarkers based on it are applicable for the diagnosis of a wide range of both pulmonary and other diseases. The principles of operation, advantages and disadvantages of polarizer design options are outlined. The main attention is paid to new approaches and technical solutions that determine the trends in the development of the methodology.

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HP-Xe to go: Storage and transportation of hyperpolarized 129Xenon

Cited by 7 publications

References 8 publications

Precise measurement of magnetic field gradients from free spin precession signals of 3He and 129Xe magnetometers

Precise measurement of magnetic field gradients from free spin precession signals of 3He and 129Xe magnetometers

Hyperpolarized solution-state NMR spectroscopy with optically polarized crystals

Методы Получения Поляризованного Ксенона Для Магнитно-Резонансной Томографии (Обзор)

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