HP-NAP new therapy for bladder cancer: numquam periculum sine periculo vincitur

Codolo, Gaia; Fassan, Matteo; D’Elios, Mario Milco; Bernard, Marina de

doi:10.1007/s00262-011-1145-9

Cited by 1 publication

(1 citation statement)

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“…Codolo and colleagues showed that local administration of HP-NAP decreases tumor growth by triggering tumor necrosis in a mouse model of bladder cancer. HP-NAP-treated tumors show also a reduced vascularization due to the anti-angiogenic activity of IFN-γ induced by treatment of cancer implants with HP-NAP (Codolo et al, 2012a;Codolo et al, 2012b). In sum it should be pointed out that even persistent infection with H. pylori may be linked to protection from some autoimmune diseases, it is not recommended to leave H. pylori infection untreated in asthmatic patients.…”

Section: Correlation Between Helicobacter Pylori Infection and Asthmamentioning

confidence: 99%

The Controversy over Anti-Helicobacter pylori Therapy

Bocian

Jagusztyn-Krynicka²

2012

Pol J Microbiol

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Helicobacter pylori is a Gram-negative spiral-shaped bacterium, member of epsilon-Proteobacteria specifically colonizing the gastric epithelium of humans. It causes one of the most common infections worldwide, affecting about half of the world's population. However, it should be noted that the prevalence of H. pylori, particularly in the Western world, has significantly decreased coinciding with an increase of some autoimmune and allergic diseases, such as asthma. Various epidemiological studies have also documented a negative association between H. pylori colonization and the presence of GERD (gastroesophageal reflux disease) and risk of esophageal cancer. Additionally, an upward trend of obesity recently observed in inhabitants of developed countries raised a question about the relationship between H. pylori infection and the human body mass index. The first part of this review describes common, recommended anti-H. pylori treatments. The second part, presents the results of recent experiments aimed at evaluating the association between H. pylori infections and gastro-esophageal diseases, the level of stomach hormones, the human body mass index and allergic diseases. Although some studies suggest an inverse association of H. pylori infection with some health problems of the modern world such as asthma, obesity or GERD, H. pylori should be considered as a harmful human pathogen responsible for serious and sometimes lethal diseases. Thus, many scientists advocate the eradication of H. pylori.

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Section: Correlation Between Helicobacter Pylori Infection and Asthmamentioning

confidence: 99%