2020
DOI: 10.1186/s12885-020-07441-9
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HOXD-AS1 facilitates cell migration and invasion as an oncogenic lncRNA by competitively binding to miR-877-3p and upregulating FGF2 in human cervical cancer

Abstract: Background Long non-coding RNAs (LncRNAs) are dysregulated in multiple human cancers and they are highly involved in tumor progression. Previous studies have identified the oncogenic lncRNA HOXD cluster antisense RNA 1 (HOXD-AS1) in human cancers, while its roles in cervical cancer (CC) remain unclear. Herein we intended to characterize the implication of HOXD-AS1 in CC. Methods qRT-PCR was applied to examine the relative expression of HOXD-AS1 in CC tissues, cell lines and transfected cells. Wound healing a… Show more

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Cited by 24 publications
(22 citation statements)
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References 28 publications
(35 reference statements)
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“… 27 , 28 Several studies have shown that HAGLR is associated with the proliferation, invasion, and metastasis of tumor cells. 29–34 Besides, the prognostic value of HAGLR in tumors has been evaluated. For example, Dong et al revealed that high expression of HAGLR is positively correlated with poorer prognosis of epithelial ovarian cancer patients.…”
Section: Discussionmentioning
confidence: 99%
“… 27 , 28 Several studies have shown that HAGLR is associated with the proliferation, invasion, and metastasis of tumor cells. 29–34 Besides, the prognostic value of HAGLR in tumors has been evaluated. For example, Dong et al revealed that high expression of HAGLR is positively correlated with poorer prognosis of epithelial ovarian cancer patients.…”
Section: Discussionmentioning
confidence: 99%
“…Although the functions of miR-877-3p have not been widely addressed, several studies of miR-877-3p have been reported. Zhu et al reported that enforced expression of miR-877-3p increased the expression of P16, which inhibits the proliferation of bladder cancer and Chen et al reported that overexpression of miR-877-3p abolished the migration and invasion of cervical cancer cell lines induced by HOXD-AS1 [ 35 , 36 ]. Another study showed the promotion of osteoblast differentiation of MC3T3-E1 cells by overexpression of miR-877-3p.…”
Section: Discussionmentioning
confidence: 99%
“…It is well established that most lncRNAs transmitted by exosomes located at the cytoplasm of the recipient, function as ceRNA to bind with miRNAs, which subsequently facilitate target gene expression [10]. HOXD-AS1 has been well characterized as a ceRNA to modulate progression in a variety of cancers, including glioma [33], hepatocellular carcinoma [34] and cervical cancer [35]. However, it's role as exosomal lncRNA in PCa cells remains unclear.…”
Section: Discussionmentioning
confidence: 99%