HOXA5 is a tumor suppressor gene that is decreased in gastric cancer

Peng, Xudong; Zha, Lang; Chen, Anqi; Wang, Ziwei

doi:10.3892/or.2018.6537

Cited by 23 publications

(22 citation statements)

References 31 publications

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“…Here, we revealed that Hoxa5 was direct target of miR-19a-3p and contribute to miR-19a-3p-induced BMSC osteogenic differentiation. Hoxa5 was served as tumor suppressor in a number of cancers including non-small cell lung cancer [28], osteosarcoma [29], gastric cancer [30] and gastric cancer [31]. Hoxa5 was also reported to alleviate inflammation and induce adipose tissue browning [32].…”

Section: Discussionmentioning

confidence: 99%

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Chen¹,

Li²,

Zhi³

et al. 2020

Aging and disease

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The switch between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a key role in aging-induced osteoporosis. In this study, miR-19a-3p was obviously downregulated in BMSCs from aged humans and mice. Overexpressed miR-19a-3p evidently reduced aginginduced bone loss in mice and promoted osteogenic differentiation of BMSCs, while silenced miR-19a-3p manifestly increased aging-induced bone loss in mice and repressed osteogenic differentiation of BMSCs. Hoxa5 was significantly downregulated in the BMSCs from aged mice and contribute to miR-19a-3p-induced osteoblast differentiation as a direct target gene of miR-19a-3p. Furthermore, lncRNA Xist was found as a sponge of miR-19a-3p to repress BMSCs osteogenic differentiation. In conclusion, our study reveals the critical role of the lncRNA Xist/miR-19a-3p/Hoxa5 pathway in aging-induced osteogenic differentiation of BMSCs, indicating the potential therapeutic target for osteoporosis.

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Section: Discussionmentioning

confidence: 99%

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Chen¹,

Li²,

Zhi³

et al. 2020

Aging and disease

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“…HOXD10 suppresses the migration and invasion of GC cells through insulin-like growth factor binding protein-3 (IGFBP3) and RhoC-AKT pathway (36,39). HOXA5 suppresses GC progression by inhibiting the G1/S transition during the cell cycle (17). HOXA13 promotes GC development via TGF-β, ERK1/2, MDM2-p53-MRP1 pathways, and Wnt/β-catenin signalling (23,(41)(42)(43).…”

Section: Publication Biasmentioning

confidence: 99%

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Jin

Dai

et al. 2020

Preprint

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Background: An increasing number of studies have described the aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with the prognosis and clinicopathological characteristics of GC. This study was conducted to investigate the clinical value and action mechanisms of HOX proteins in GC. Methods: A comprehensive search of PubMed, Embase, Web of Science and Cochrane Library was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The pooled hazard ratio (HR) with its 95% confidence interval (95% CI) and the pooled odds ratio (OR) with its 95% CI were used to assess the effect of HOX protein expression on the prognosis and clinicopathological features of GC, respectively. Results: Nineteen studies containing 3775 patients were selected for this study. Heterogeneity among HRs of overall survival (OS) was markedly high (I2=90.5%, p=0.000). According to the subgroup analysis, increased expression of HOX protein in the downregulated subgroup was associated with a good prognosis for patients with GC (pooled HR: 0.46, 95% CI: 0.36-0.59, I2=3.1%, p=0.377), while overexpression of HOX protein in the upregulated subgroup was correlated with a reduced OS (pooled HR: 2.59, 95% CI: 1.79-3.74, I2=73.5%, p=0.000). The aberrant expression of HOX protein was crucially related to the TNM stage, depth of tumour invasion, tumour size, lymph node metastasis, distant metastasis, vascular invasion, histological differentiation and Lauren classification in patients with GC. In addition, the molecular mechanisms by which HOX proteins regulate tumorigenesis and development of GC were also explored. Conclusions: HOX proteins play vital roles in GC progression, which might serve as prognostic markers and therapeutic targets for GC.

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“…All included studies were from China, Japan and Korea, and published between 2012 and 2019. These studies involve the following HOX proteins: HOXB9 (15), HOXD10 (16), HOXA5 (17,18), HOXA10 (19)(20)(21), HOXA13 (22,23), HOXC6 (24), HOXB7 (25,26), HOXA1 (27), HOXA9 (28), HOXC9 (29), HOXC10(30), HOXD4 (31), HOXA11 (32) and HOXD9 (33). These studies explored the prognostic value of HOX proteins expression for OS or disease-free survival (DFS), and the correlation between HOX proteins expression and clinicopathological parameters in GC.…”

Section: Study Characteristicsmentioning

confidence: 99%

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Jin

Dai

et al. 2020

Preprint

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Background Increasing studies have uncovered aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with prognosis and clinicopathological characteristics of GC. This study was conducted to investigate the clinical value and potential acting mechanisms of HOX proteins in GC.Methods A comprehensive search on PubMed, Embase, Web of Science and Cochrane Library was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. The pooled hazard ratio (HR) with its 95% confidence interval (95% CI) and the pooled odds ratio (OR) with its 95% CI were used to assess the effect of HOX proteins expression on the prognosis and clinicopathological features of GC, respectively.Results A total of 19 studies involving 3775 patients were selected for this study. Heterogeneity among HRs of overall survival (OS) was markedly high (I2 = 90.5%, p = 0.000). The subgroup analysis showed that elevated expression of HOX proteins in the down-regulated subgroup was associated with a good prognosis in GC. (pooled HR: 0.46, 95% CI: 0.36–0.59, I2 = 3.1%, p = 0.377), while over-expressed HOX proteins in the up-regulated subgroup were related to poor OS. (pooled HR: 2.59, 95% CI: 1.79–3.74, I2 = 73.5%, p = 0.000). The aberrant expression of HOX proteins was crucially related to the TNM stage, depth of tumor invasion, tumor size, lymph node metastasis, distant metastasis, vascular invasion, histological differentiation and Lauren classification in GC. In addition, the molecular mechanisms how HOX proteins regulate tumorigenesis and development of GC were also explored.Conclusions HOX proteins play vital roles in GC progression and might serve as prognostic markers for GC. Novel therapeutic strategies targeting HOX proteins might be promising for GC prevention and therapy.

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HOXA5 is a tumor suppressor gene that is decreased in gastric cancer

Cited by 23 publications

References 31 publications

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

lncRNA Xist Regulates Osteoblast Differentiation by Sponging miR-19a-3p in Aging-induced Osteoporosis

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

Homeobox proteins are potential biomarkers and therapeutic targets in gastric cancer: a systematic review and meta-analysis

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