HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage

Yang, Yihua; Chen, Xiaoyan; Saravelos, Sotirios H.; Liu, Yingyu; Huang, Jin; Zhang, Jiamiao; Li, Tin‐Chiu

doi:10.1016/j.fertnstert.2016.09.016

Cited by 56 publications

(44 citation statements)

References 46 publications

(58 reference statements)

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“…Peak HOXA10 and HOXA11 expressions are first observed during the window of endometrial receptivity. Decreased HOXA10 expression leads to a decreased implantation rate; furthermore, HOXA10 expression is significantly low in cases of recurrent miscarriage and recurrent implantation failure [15]. Recently, it was reported that BPA exposure results in downregulation of HOXA10 [37].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, LIF deficiency results in the loss of embryos during early pregnancy in murine [12,13,14]. A low expression of HOXA10 mRNA results in a decreased implantation rate [15]; whereas, downregulation of MUC1 mRNA and its protein prior to implantation allows the embryo to attach to the maternal uterus [5,16,17]. Furthermore, LIF and MUC1 were shown to enhance the calcium ion level in in vitro experiments [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse

Tran

Jung

Ahn

et al. 2018

IJERPH

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Miscarriage due to blastocyst implantation failure occurs in up to two-thirds of all human miscarriage cases. Calcium ion has been shown to be involved in many cellular signal transduction pathways as well as in the regulation of cell adhesion, which is necessary for the embryo implantation process. Exposure to endocrine-disrupting chemicals (EDs) during early gestation results in disruption of intrauterine implantation and uterine reception, leading to implantation failure. In this study, ovarian estrogen (E2), bisphenol A (BPA), or 4-tert-octylphenol (OP), with or without ICI 182,780 (ICI) were injected subcutaneously from gestation day 1 to gestation day 3 post-coitus. The expression levels of the calcium transport genes were assessed in maternal uteri and implantation sites. The number of implantation sites was significantly low in the OP group, and implantation sites were absent in the E2, ICI and EDs + ICI groups. There were different calcium transient transport channel expression levels in uterus and implantation site samples. The levels of TRPV5 and TRPV6 gene expression were significantly increased by EDs with/without ICI treatment in utero. Meanwhile, TRPV5 and TRPV6 gene expression were significantly lower in implantation sites samples. NCX1 and PMCA1 mRNA levels were significantly decreased by OP and BPA in the implantation site samples. Compared to vehicle treatment in the uterus, both the MUC1 mRNA and protein levels were markedly high in all but the BPA group. Taken together, these results suggest that both BPA and OP can impair embryo implantation through alteration of calcium transport gene expressions and by affecting uterine receptivity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse

Tran

Jung

Ahn

et al. 2018

IJERPH

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“…In mice, expression of E-cadherin in the uterus was reported to increase under progesterone influence [41]. The importance of E-cadherin in implantation was evidenced from the observed low E-cadherin level in infertile women who suffer from recurrent implantation failure and miscarriages [42]. In the meantime, expression of integrin avb3 in early pregnancy period was also found to be reduced following high dose quercetin administration.…”

Section: Discussionmentioning

confidence: 96%

Quercetin interferes with the fluid volume and receptivity development of the uterus in rats during the peri-implantation period

Shahzad

Giribabu

Karim

et al. 2017

Reproductive Toxicology

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“…7 Since then, integrin, 8 glycodelin, 9 mucin 1, 10 leukemia inhibitory factor (LIF), 8,11 and HOXA-10 transcription factor 12 have also been described as potential endometrial biomarkers. Pinopodes were reported as a biomarker to assess endometrial receptivity since their putative expression coincides with the window of implantation.…”

Section: Introductionmentioning

confidence: 99%

“…Pinopodes were reported as a biomarker to assess endometrial receptivity since their putative expression coincides with the window of implantation. 7 Since then, integrin, 8 glycodelin, 9 mucin 1, 10 leukemia inhibitory factor (LIF), 8,11 and HOXA-10 transcription factor 12 have also been described as potential endometrial biomarkers. Nevertheless, only a few markers are currently utilized in clinical practice due to the conflicting results and technical difficulties for their use on patients.…”

Section: Introductionmentioning

confidence: 99%

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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Intrauterine infusion of human chorionic gonadotropin (IUI‐hCG) has been proposed to improve the outcome of in vitro fertilization‐embryo transfer (IVF‐ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI‐hCG on IVF‐ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI‐hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI‐hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI‐hCG should be highlighted in the future.

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HOXA-10 and E-cadherin expression in the endometrium of women with recurrent implantation failure and recurrent miscarriage

Cited by 56 publications

References 46 publications

Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse

Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse

Quercetin interferes with the fluid volume and receptivity development of the uterus in rats during the peri-implantation period

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

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