Hox clusters and bilaterian phylogeny

Balavoine, Guillaume; Rosa, Renaud de; Adoutte, André

doi:10.1016/s1055-7903(02)00237-3

Cited by 124 publications

(102 citation statements)

References 38 publications

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“…DOI: 10.1002/jez.b.21208 Hox genes has contributed significantly to resolve important issues in metazoan phylogeny. For instance, they provide strong support for the monophyly of Bilateria (Balavoine et al, 2002), they provide a major line of support (de Rosa et al,'99) for the Ecdysozoa/Lophotrochozoa hypothesis (Aguinaldo et al,'97), and they have been a major reason to classify Acoelomorpha Ruiz-Trillo et al, 2002;Telford et al, 2003) (including Acoela and Nemertodermatida) as basal bilaterians rather than within Platyhelminthes (Cook et al, 2004;Jiménez-Guri et al, 2006;Olson, 2008).…”

mentioning

confidence: 99%

PCR survey of Xenoturbella bocki Hox genes

Fritzsch¹,

Böhme²,

Thorndyke³

et al. 2007

J Exp Zool Pt B

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Xenoturbella bocki has recently been identified as one of the most basal deuterostomes, although an even more basal phylogenetic position cannot be ruled out. Here we report on a polymerase chain reaction survey of partial Hox homeobox sequences of X. bocki. Surprisingly, we did not find evidence for more than five Hox genes, one clear labial/PG1 ortholog, one posterior gene most similar to the PG9/10 genes of Ambulacraria, and three central group genes whose precise assignment to a specific paralog group remains open. We furthermore report on a re-evaluation of the available published evidence of Hox genes in other basal deuterostomes.

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mentioning

confidence: 99%

PCR survey of Xenoturbella bocki Hox genes

Fritzsch¹,

Böhme²,

Thorndyke³

et al. 2007

J Exp Zool Pt B

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“…The presence of Post1 and Post2, as distinct from ecdysozoan AbdB or deuterostome Hox9-15 sequences, can be taken as a character that unites the lophotrochozoans. Similarly the lophotrochozoans are distinguished by diagnostic central Hox gene sequences as well, such as Lox2, Lox4 and Lox5 (de Rosa et al, 1999;Balavoine et al, 2002). The Hox cluster genes pattern the development of the anterior-posterior axis of bilaterian embryos (Lemons & McGinnis, 2006).…”

Section: Genome Evolutionmentioning

confidence: 99%

Annelids in evolutionary developmental biology and comparative genomics

et al. 2008

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Summary :Annelids have had a long history in comparative embryology and morphology, which has helped to establish them in zoology textbooks as an ideal system to understand the evolution of the typical triploblastic, coelomate, protostome condition. In recent years there has been a relative upsurge in embryological data, particularly with regard to the expression and function of developmental control genes. Polychaetes, as well as other annelids such as the parasitic leech, are now also entering the age of comparative genomics. All of this comparative data has had an important impact on our views of the ancestral conditions at various levels of the animal phylogeny, including the bilaterian ancestor and the nature of the annelid ancestor. Here we review some of the recent advances made in annelid comparative development and genomics, revealing a hitherto unsuspected level of complexity in these ancestors. It is also apparent that the transition to a parasitic lifestyle leads to, or requires, extensive modifications and derivations at both the genomic and embryological levels.

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“…In Ubx, a short motif located downstream of the HD conveys Exd interaction potential (18). This motif, UbdA, 8 aa long, is shared exclusively by the central paralog proteins Ubx and AbdA and is found only in protostomes (19,20).…”

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confidence: 99%

Selection of distinct Hox–Extradenticle interaction modes fine-tunes Hox protein activity

Saadaoui

Merabet

Litim-Mecheri

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Hox genes encode transcription factors widely used for diversifying animal body plans in development and evolution. To achieve functional specificity, Hox proteins associate with PBC class proteins, Pre-B cell leukemia homeobox (Pbx) in vertebrates, and Extradenticle (Exd) in Drosophila, and were thought to use a unique hexapeptide-dependent generic mode of interaction. Recent findings, however, revealed the existence of an alternative, UbdA-dependent paralog-specific interaction mode providing diversity in Hox-PBC interactions. In this study, we investigated the basis for the selection of one of these two Hox-PBC interaction modes. Using naturally occurring variations and mutations in the Drosophila Ultrabithorax protein, we found that the linker region, a short domain separating the hexapeptide from the homeodomain, promotes an interaction mediated by the UbdA domain in a context-dependent manner. While using a UbdA-dependent interaction for the repression of the limb-promoting gene Distalless, interaction with Exd during segment-identity specification still relies on the hexapeptide motif. We further show that distinctly assembled Hox-PBC complexes display subtle but distinct repressive activities. These findings identify Hox-PBC interaction as a template for subtle regulation of Hox protein activity that may have played a major role in the diversification of Hox protein function in development and evolution.transcriptional regulation | AbdominalA | Hox protein specificity and diversity

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Hox clusters and bilaterian phylogeny

Cited by 124 publications

References 38 publications

PCR survey of Xenoturbella bocki Hox genes

PCR survey of Xenoturbella bocki Hox genes

Annelids in evolutionary developmental biology and comparative genomics

Selection of distinct Hox–Extradenticle interaction modes fine-tunes Hox protein activity

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