How widespread is preparation for oxidative stress in the animal kingdom?

Moreira, Daniel C.; Venâncio, Larissa Paola Rodrigues; Sabino, Marcus A.C.T.; Hermes‐Lima, Marcelo

doi:10.1016/j.cbpa.2016.01.023

Cited by 58 publications

(54 citation statements)

References 149 publications

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“…Finally, the presence of antioxidant peptides in the amphibian skin secretions leads to a better understanding about the adaptative physiology of these animals. Indeed, endogenous antioxidants are key for the survival and adaptation of animals to the environment [71]. In addition, it suggests future cellular studies using antioxidant peptides in topical formulations for antiaging pharmaceuticals, or as putative neuroprotectors, which may assist in the development of therapeutic strategies aiming at controlling oxidative stress in neurological disease.…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra)

et al. 2020

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Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and water balance. In this study, skin secretion samples of the fire salamander (Salamandra salamandra) were separated using RP-HPLC and de novo sequenced using MALDI-TOF MS/MS. Next, we used an in silico platform to screen antioxidant molecules in the framework of density functional theory. One of the identified peptides, salamandrin-I, [M + H]+ = 1406.6 Da, was selected for solid-phase synthesis; it showed free radical scavenging activity against DPPH and ABTS radicals. Salamandrin-I did not show antimicrobial activity against Gram-positive and -negative bacteria. In vitro assays using human microglia and red blood cells showed that salamandrin-I has no cytotoxicity up to the concentration of 100 µM. In addition, in vivo toxicity tests on Galleria mellonella larvae resulted in no mortality at 20 and 40 mg/kg. Antioxidant peptides derived from natural sources are increasingly attracting interest. Among several applications, these peptides, such as salamandrin-I, can be used as templates in the design of novel antioxidant molecules that may contribute to devising strategies for more effective control of neurological disease.

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Section: Discussionmentioning

confidence: 99%

The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra)

et al. 2020

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“…This requires such organisms to increase their antioxidant defenses before triggering metabolic shutdown in order to counteract the burst of ROS generated upon reperfusion. A recent literature review by Moreira et al (2016b) shows that the diversity of organisms capable of POS is phylogenetically broad, suggesting that this is an old and relatively conserved mechanism.…”

Section: Redox Metabolismmentioning

confidence: 99%

Osmoregulation, bioenergetics and oxidative stress in coastal marine invertebrates: raising the questions for future research

Rivera‐Ingraham

Lignot

2017

Journal of Experimental Biology

135

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Osmoregulation is by no means an energetically cheap process, and its costs have been extensively quantified in terms of respiration and aerobic metabolism. Common products of mitochondrial activity are reactive oxygen and nitrogen species, which may cause oxidative stress by degrading key cell components, while playing essential roles in cell homeostasis. Given the delicate equilibrium between pro-and antioxidants in fueling acclimation responses, the need for a thorough understanding of the relationship between salinity-induced oxidative stress and osmoregulation arises as an important issue, especially in the context of global changes and anthropogenic impacts on coastal habitats. This is especially urgent for intertidal/ estuarine organisms, which may be subject to drastic salinity and habitat changes, leading to redox imbalance. How do osmoregulation strategies determine energy expenditure, and how do these processes affect organisms in terms of oxidative stress? What mechanisms are used to cope with salinity-induced oxidative stress? This Commentary aims to highlight the main gaps in our knowledge, covering all levels of organization. From an energy-redox perspective, we discuss the link between environmental salinity changes and physiological responses at different levels of biological organization. Future studies should seek to provide a detailed understanding of the relationship between osmoregulatory strategies and redox metabolism, thereby informing conservation physiologists and allowing them to tackle the new challenges imposed by global climate change.

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“…Oxidative stress can arise from overproduction of ROS by fatty acid β-oxidation and is defined as an imbalance between ROS production and antioxidant defense system. During fasting, many animals enhance their antioxidant defenses to cope with oxidative stress (Moreira et al, 2016). For example, lipid peroxidation and oxidative stress were strengthened in the liver of 72 h-fasted rats (Sorensen et al, 2006); the expression levels of antioxidant enzymes were up-regulated in the liver of 24 h-fasted mice (Sokolovic et al, 2008); antioxidant defense mechanism was activated in the liver of fish after 5 weeks of fasting (Morales et al, 2004).…”

Section: Prolonged Fasting Up-regulates Ros Production and Antioxidanmentioning

confidence: 99%

Differential Proteomic Analysis of Chinese Giant Salamander Liver in Response to Fasting

et al. 2020

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Chinese giant salamander Andrias davidianus has strong tolerance to starvation. Fasting triggers a complex array of adaptive metabolic responses, a process in which the liver plays a central role. Here, a high-throughput proteomic analysis was carried out on liver samples obtained from adult A. davidianus after 3, 7, and 11 months of fasting. As a result, the expression levels of 364 proteins were significantly changed in the fasted liver. Functional analysis demonstrated that the expression levels of key proteins involved in fatty acid oxidation, tricarboxylic acid cycle, gluconeogenesis, ketogenesis, amino acid oxidation, urea cycle, and antioxidant systems were increased in the fasted liver, especially at 7 and 11 months after fasting. In contrast, the expression levels of vital proteins involved in pentose phosphate pathway and protein synthesis were decreased after fasting. We also found that fasting not only activated fatty acid oxidation and ketogenesis-related transcription factors PPARA and PPARGC1A, but also activated gluconeogenesis-related transcription factors FOXO1, HNF4A, and KLF15. This study confirms the central role of lipid and acetyl-CoA metabolism in A. davidianus liver in response to fasting at the protein level and provides insights into the molecular mechanisms underlying the metabolic response of A. davidianus liver to fasting.

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How widespread is preparation for oxidative stress in the animal kingdom?

Cited by 58 publications

References 149 publications

The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra)

The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra)

Osmoregulation, bioenergetics and oxidative stress in coastal marine invertebrates: raising the questions for future research

Differential Proteomic Analysis of Chinese Giant Salamander Liver in Response to Fasting

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