How Well Do We Manage the Odontogenic Keratocyst? a Multicenter Study

Kinard, Brian; Hansen, Gentry; Newman, Marshall F.; Dennis, Peter; Haeffs, Tyler H.; Pérez, Sebastián Celestino; Sakamoto, Hamao; Steed, Martin B.; Hughes, Pamela J.; August, Meredith; Abramowicz, Shelly

doi:10.1016/j.oooo.2018.05.057

Cited by 3 publications

(3 citation statements)

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“…OKCs might present as both unilocular and multilocular lesions with unilocular being the predominant. 19 In our study a total of 100 patients had unilocular lesions and 80 had multilocular lesions. Recurrence was more in multilocular lesions however; radiographic presentation was not an independent risk factor.…”

Section: Discussionmentioning

confidence: 58%

“…Most of the recurrences occurred in rst 5 years with decreasing incidence on subsequent years and the difference was statistically signi cant. 17,18 A 2019 study by Kinard et al 19 had an overall 19% recurrence with a median follow up of 8 months. In their study maxillary lesions had more recurrence compared to mandible and multilocular lesions were signi cantly associated with recurrence.…”

Section: Discussionmentioning

confidence: 99%

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Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws

Bera

Tandon

Tiwari

et al. 2023

J. Maxillofac. Oral Surg.

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Introduction: The incidence of recurrence of OKC varied from 2.5%-62%. Studies have linked recurrence to treatment methods and also clinical and pathological features. The aim of this study was to evaluate the 5 year recurrence and the factors associated with recurrence in odontogenic keratocysts of the jaws. Methods: A retrospective review of records was done from the Institute's Medical Records Directory from 2010-2021. The following data were obtained of the lesion; age at presentation, gender, site, subsite, radiographic presentation (locularity), radiographic borders, presence or absence of satellite cysts, in ammatory in ltrate, and treatment rendered presence or absence of cortical perforation and soft tissue extension and presence or absence of recurrence. Kaplan Meir estimator was used to evaluate recurrence rate and log rank test was used to compare the survival amongst groups. Cox regression analysis was used to evaluate the odds ratio to nd out the possible factors in uencing risk of recurrence. A p value of <0.05 was considered statistically signi cant at 95% con dence interval.Results: In our study cohort 44.44% had recurrence. Multilocular lesions, lesions with scalloped borders, presence of soft tissue extension and cortical perforation, presence of satellite cysts and in ammatory in ltrate and enucleation with peripheral ostectomy were signi cantly associated with recurrence. However; soft tissue extension, cortical perforation, enucleation with peripheral ostectomy and marsupialization followed by enucleation+ peripheral ostectomy were independent risk factors.Conclusion: There is still debate on the best treatment modality for the management of OKCs. More studies are required to quantify the results.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws

Bera

Tandon

Tiwari

et al. 2023

J. Maxillofac. Oral Surg.

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“…Although OKC usually grows slowly, it shows an infiltrative course that can be related to its recurrence rates. Numerous investigations have demonstrated molecular alterations in the lesion, but they do not fully explain the lesion´s clinical behavior characterized by its high‐recurrence rate despite being a benign condition (Chrcanovic & Gomez, 2017; Gomes et al., 2017; Kinard et al., 2019; Qu et al., 2019).…”

Section: Introductionmentioning

confidence: 99%

Unveiling metabolic changes in marsupialized odontogenic keratocyst: A pilot study

et al. 2021

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Objective: We aimed to assess which metabolic pathways would be implicated in the phenotypic changes of the epithelial lining of odontogenic keratocyst after marsupialization, comparing pre-and post-marsupialized lesions with adjacent oral mucosa. Materials and Methods:Eighteen formalin-fixed and paraffin-embedded tissues from six subjects were divided into three paired groups: odontogenic keratocyst pre-(n = 6) and post-marsupialization (n = 6), and adjacent oral mucosa (n = 6). The metabolic pathways found in these groups were obtained by high-performance liquid chromatography-mass spectrometry-based untargeted metabolomics performed.Results: Through putative metabolite annotation followed by pathway enrichment and predictive analysis with automated algorithms (Mummichog and Gene Set Enrichment Analysis), we found differences in many cellular processes that may be involved in inflammation, oxidative stress response, keratinocyte-basal membrane attachment, differentiation, and proliferation functions, all relevant to odontogenic keratocyst pathobiology and the phenotype acquired after marsupialization. Conclusion:Our study was able to identify several metabolic pathways potentially involved in the metaplastic changes induced by marsupialization of odontogenic keratocysts. An improved comprehension of this process could pave the way for the development of targeted therapies.

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Recurrence and prognosticators of recurrence in odontogenic keratocyst of the jaws.

Bera

Tandon

Tiwari

2022

Preprint

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Introduction: The incidence of recurrence of OKC varied from 2.5%-62%. Studies have linked recurrence to treatment methods and also clinical and pathological features. The aim of this study was to evaluate the 5 year recurrence and the factors associated with recurrence in odontogenic keratocysts of the jaws.Methods: A retrospective review of records was done from the Institute’s Medical Records Directory from 2010-2021. The following data were obtained of the lesion; age at presentation, gender, site, subsite, radiographic presentation (locularity), radiographic borders, presence or absence of satellite cysts, inflammatory infiltrate, and treatment rendered presence or absence of cortical perforation and soft tissue extension and presence or absence of recurrence. Kaplan Meir estimator was used to evaluate recurrence rate and log rank test was used to compare the survival amongst groups. Cox regression analysis was used to evaluate the odds ratio to find out the possible factors influencing risk of recurrence. A p value of <0.05 was considered statistically significant at 95% confidence interval. Results: In our study cohort 44.44% had recurrence. Multilocular lesions, lesions with scalloped borders, presence of soft tissue extension and cortical perforation, presence of satellite cysts and inflammatory infiltrate and enucleation with peripheral ostectomy were significantly associated with recurrence. However; soft tissue extension, cortical perforation, enucleation with peripheral ostectomy and marsupialization followed by enucleation+ peripheral ostectomy were independent risk factors. Conclusion: There is still debate on the best treatment modality for the management of OKCs. More studies are required to quantify the results.

show abstract

How Well Do We Manage the Odontogenic Keratocyst? a Multicenter Study

Cited by 3 publications

References 0 publications

Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws

Recurrence and Prognosticators of Recurrence in Odontogenic Keratocyst of the Jaws

Unveiling metabolic changes in marsupialized odontogenic keratocyst: A pilot study

Recurrence and prognosticators of recurrence in odontogenic keratocyst of the jaws.

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