How well do image-defined risk factors (IDRFs) predict surgical outcomes and survival in patients with neuroblastoma? A systematic review and meta-analysis

Parhar, Dennis; Joharifard, Shahrzad; Lo, Andrea; Schlosser, Mary-Pat; Daodu, Oluwatomilayo

doi:10.1007/s00383-020-04696-y

Cited by 19 publications

(19 citation statements)

References 29 publications

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“…Since the introduction of Image-Defined Risk Factors (IDRFs) to the International Neuroblastoma Risk Group (INRG) staging system in 2009, their role in predicting surgical complications has been analyzed by many authors [ 8 ]. According to the INRG classification, the presented patient was in group L2 [ 9 ] ( Figure 1 ).…”

Section: Discussionmentioning

confidence: 99%

The Dramatic Consequences of an Accidental Ligation of the Celiac Trunk during Surgery Performed on a Child with Neuroblastoma

Sosnowska-Sienkiewicz

Januszkiewicz‐Lewandowska

Mańkowski

2021

IJERPH

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Neuroblastoma is the most common extra-cranial solid tumor in infants and young children, and accounts for approximately 8–10% of all childhood cancers. The International Neuroblastoma Staging System (INRGSS) is based on the age of patient and preoperative imaging, with attention paid to whether the primary tumor is affected by one or more of specific Image-Defined Risk Factors (IDRFs). Patients are classified into the following groups: locoregional L1 and L2 (absent or present IDRFs respectively), M stage (a disseminated form of neuroblastoma) and Ms (the stage present in children younger than 18 months of age with the disease spread to the bone marrow and/or liver, and/or skin). This publication is aimed to present an unexpected complication associated with an accidental ligation of the celiac trunk during resection of a neuroblastoma tumor in a 2.5-year-old boy after initial chemotherapy, initially with vascular IDRFs, stage L2. The consequences of this complication were pancreatic and spleen ischemia and necrosis, and ischemia and perforation of the common bile duct, gallbladder, stomach, and duodenum. Despite detailed diagnostic imaging (computed tomography, magnetic resonance), the presence of vascular IDRFs may result in an unexpected complication in the surgical treatment of neuroblastoma in children.

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Section: Discussionmentioning

confidence: 99%

The Dramatic Consequences of an Accidental Ligation of the Celiac Trunk during Surgery Performed on a Child with Neuroblastoma

Sosnowska-Sienkiewicz

Januszkiewicz‐Lewandowska

Mańkowski

2021

IJERPH

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“…18,22 Clear guidelines for surgical interventions contribute to evidence-based operative procedures of NB, based on the image-defined risk factors that have been developed. [23][24][25] Furthermore, a reporting standard has been developed for NB surgical procedures. 26 Autologous stem cell TA B L E 3 The view on the management of neuroblastoma according to World Bank Lending and Income Group (p = .006) being a significant burden on resources.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment intensity of the SIOPEN and COG protocols may not be beneficial to LMIC, but management adapted for local setting, like the NB SIOP‐PODC risk stratification and treatment guidelines, may be feasible as proven by a study from Morocco 18,22 . Clear guidelines for surgical interventions contribute to evidence‐based operative procedures of NB, based on the image‐defined risk factors that have been developed 23–25 . Furthermore, a reporting standard has been developed for NB surgical procedures 26 .…”

Section: Discussionmentioning

confidence: 99%

Neuroblastoma: The basis for cure in limited‐resource settings

Heerden

Kruger

Esterhuizen

et al. 2021

Pediatric Blood & Cancer

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Background: Neuroblastoma (NB) contributes the most to the mortality of childhood malignancies worldwide. The disease spectrum is heterogenous and the management complex and costly, especially in advanced disease or disease with adverse biology. In low-and middle-income countries (LMICs) the majority of NB presents in advanced stages. Therefore, with limited resources and poor prognosis the treatment of NB is often not a priority. The aim of the study was to evaluate the research activities and perceptions of the management of NB that determine the research and treatment approaches in LMICs. Methods: Data were sourced from https://www.clinicaltrials.gov/ identifying NB trials open to LMIC. Abstracts on NB research presented at the International Society for Paediatric Oncology (SIOP) Congresses between 2014 and 2020 were evaluated according to income status. An online survey evaluating medical views on NB in LMICs and the effect on the management was conducted. Descriptive analysis was done. Where appropriate categorical association between covariates was assessed using the Pearson chi-square (χ 2 ) test or Fishers exact test. Results: There were 15/562 (2.7%) trials open to LMIC. Only six of 138 (4.3%) LMIC participated in NB trials. Of the 688 abstracts presented between 2014 and 2020 at the SIOP International Congress on NB as primary subject, 297 (42.7%) were from LMICs. Only two were from low-income countries (LICs). Sixty-one countries responded to the NB survey. Positive views towards NB management were present when treatment was based on a national protocol, the availability of trimodal or advanced treatment options were present, and when a balance of metastatic or local disease were treated. Conclusion: Management of NB in LMICs should include increased advocacy and research as well as implementation of national management strategies.

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“…Our case had a maximum diameter of approximately 4 cm, so complete tumor excision by laparoscopic surgery was considered feasible. In addition, the preoperative evaluation of IDRF is also important for performing laparoscopic surgery 12 . The risk of open conversion should be considered preoperatively, as radiological findings may not be compatible with the intraoperative findings 2 .…”

Section: Discussionmentioning

confidence: 99%

Successful laparoscopic extirpation of a vasoactive intestinal polypeptide‐secreting neuroblastoma originating from the right adrenal gland: A report of an infantile case

Sugita

Kaji

Muto

et al. 2021

Asian J Endoscop Surgery

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We herein report a 10‐month‐old female infant with a 4‐month history of diarrhea with electrolyte abnormalities and growth impairment. A 4‐cm right adrenal tumor was detected by computed tomography. No metastasis or accumulation on I123‐metaiodobenzylguanidine scintigraphy was recognized in the tumor. A vasoactive intestinal peptide‐secreting neuroblastic tumor was suspected, and octreotide was started, but the diarrhea persisted. Tumor extirpation was laparoscopically performed. After tumor removal, the symptoms improved immediately, and her growth caught up by 9 months after surgery. A minimally invasive approach for pediatric solid tumor is difficult, especially for neuroblastoma, but may be beneficial for the patient's recovery.

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How well do image-defined risk factors (IDRFs) predict surgical outcomes and survival in patients with neuroblastoma? A systematic review and meta-analysis

Cited by 19 publications

References 29 publications

The Dramatic Consequences of an Accidental Ligation of the Celiac Trunk during Surgery Performed on a Child with Neuroblastoma

The Dramatic Consequences of an Accidental Ligation of the Celiac Trunk during Surgery Performed on a Child with Neuroblastoma

Neuroblastoma: The basis for cure in limited‐resource settings

Successful laparoscopic extirpation of a vasoactive intestinal polypeptide‐secreting neuroblastoma originating from the right adrenal gland: A report of an infantile case

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