How well are recent randomised controlled trials reported?

Milton, Julie; Logan, Stuart; Gilbert, Ruth; Patel, Sima

doi:10.1186/2048-4623-1-s3-op035

Cited by 1 publication

(1 citation statement)

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“…The whole study was devalued by complete lack of description of the means of randomisation . Although this may be seen as judging an old study by today's standards (Begg 1996), there is some evidence that quality of reporting was better in early mental health studies (Ahmed 1999) and that the CONSORT statement has made little di erence (Milton 2001).…”

Section: Implications For Researchmentioning

confidence: 99%

Benperidol for schizophrenia

Leucht

Hartung

2005

Cochrane Database of Systematic Reviews

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BackgroundBenperidol is a relatively old antipsychotic drug that has been marketed since 1966. It has been used in Germany for 30 years but is also available in Belgium, Greece, Italy, the Netherlands and the UK. Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade. Those taking it are therefore reputed to be at high risk of extrapyramidal side-e ects, but benperidol's unusual profile may render it valuable to certain subgroups of people with schizophrenia. ObjectivesTo examine the clinical e ects and safety of benperidol for those with schizophrenia and schizophrenia-like psychoses. Search methodsWe searched the Cochrane Schizophrenia Group's register (March 2009) for this update. Selection criteriaWe included all randomised controlled trials that compared benperidol with other treatments for people with schizophrenia, or schizophrenia-like psychoses. Data collection and analysisWe reliably selected studies, quality rated them and extracted data. We independently extracted data but excluded data if loss to follow up was greater than 50%. For dichotomous data, we estimated relative risks (RR), with the 95% confidence intervals (CI). Where possible, we calculated the number needed to treat/harm statistic (NNT/H) and used intention-to-treat analysis.Benperidol for schizophrenia (Review)

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Section: Implications For Researchmentioning

confidence: 99%