How we treat oral chronic graft-versus-host disease

Treister, Nathaniel S.; Duncan, Christine; Cutler, Corey; Lehmann, Leslie

doi:10.1182/blood-2012-05-393389

Cited by 80 publications

(88 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oral cGVHD was present in 23 of 26 individuals aged 14 to 67 years with oral epithelial dysplasia or squamous cell carcinoma following HSCT [89]. Host risk factors associated with an increased risk of oral cancer include younger age at HSCT and underlying cancer predisposition syndromes, such as Fanconi anemia and dyskeratosis congenita [85, 87, 88, 92, 93]. Alcohol or tobacco use also increases the risk of oral SMNs [83, 87].…”

Section: Resultsmentioning

confidence: 99%

“…Due to the concurrent and sometimes difficult distinction between cGVHD and oral SMNs, practitioners should have a low threshold for performing a biopsy on suspicious lesions [78]. There is no evidence to support tissue autofluorescence or screening biopsies in the absence of clinical signs or symptoms [93]. Survivors should be counseled to avoid carcinogenic exposures such as tobacco use, excessive alcohol, and excessive sun exposure, which increase the risk of oral and lip cancers [94] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

Effinger¹,

Migliorati²,

Hudson³

et al. 2014

Support Care Cancer

View full text Add to dashboard Cite

Purpose Multi-modality therapy has resulted in improved survival for childhood malignancies. The Children’s Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers provide practitioners with exposure- and risk-based recommendations for the surveillance and management of asymptomatic survivors who are at least 2 years from completion of therapy. This review outlines the pathophysiology and risks for oral and dental late effects in pediatric cancer survivors and the rationale for oral and dental screening recommended by the Children’s Oncology Group. Methods An English literature search for oral and dental complications of childhood cancer treatment was undertaken via MEDLINE and encompassed January 1975 to January 2013. Proposed guideline content based on the literature review was approved by a multi-disciplinary panel of survivorship experts and scored according to a modified version of the National Comprehensive Cancer Network “Categories of Consensus” system. Results The Children’s Oncology Group oral-dental pan el selected 85 relevant citations. Childhood cancer therapy may impact tooth development, salivary function, craniofacial development, and temporomandibular joint function placing some childhood cancer survivors at an increased risk for poor oral and dental health. Addition ally, head and neck radiation and hematopoietic stem cell transplantation increase the risk of subsequent ma lignant neoplasms in the oral cavity. Survivors require routine dental care to evaluate for potential side effects and initiate early treatment. Conclusions Certain childhood cancer survivors are at an increased risk for poor oral and dental health. Early identification of oral and dental morbidity and early interventions can optimize health and quality of life.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

Effinger¹,

Migliorati²,

Hudson³

et al. 2014

Support Care Cancer

View full text Add to dashboard Cite

show abstract

“…The NIH OMS (NIH OMS, scored 0–15) 10 measures the severity of each of the most common manifestations of oral cGVHD: erythema, lichenoid, mucoceles (scored 0–3) and ulcers (scored 0–6).…”

Section: Figurementioning

confidence: 99%

“…5–9 Despite its prevalence and impact on health and well-being, there remains no standard treatment of oral cGVHD. 10 …”

Section: Introductionmentioning

confidence: 99%

Validation of the National Institutes of Health chronic GVHD Oral Mucosal Score using component-specific measures

Bassim

Fassil

Mays

et al. 2013

Bone Marrow Transplant

View full text Add to dashboard Cite

Oral chronic GVHD (cGVHD) is a common, late complication of alloSCT that is associated with significant patient morbidity. The NIH Oral Mucosal Score (NIH OMS) was developed to assess oral cGVHD therapeutic response, but has not been fully validated. This study’s purpose was to conduct a rigorous construct validity and internal consistency analysis of this score and its components (erythema, lichenoid, ulcers, mucoceles) using established measures of oral pain, oral function, oral-related quality-of-life, nutrition and laboratory parameters in 198 patients with cGVHD. The construct validity of the NIH OMS was supported: a moderate correlation was observed between NIH OMS and mouth pain (rho =0.43), while a weaker correlation was observed with low albumin (rho = −0.26). Total NIH OMS, erythema and lichenoid components were associated with malnutrition, oral pain and impaired oral QOL, while ulcers were only associated with oral pain. No associations were found between mucoceles and any indicator evaluated, including salivary function or xerostomia. Kappa determined between scale components was low overall (all ≤0.35), supporting a conclusion that each component measures a distinct manifestation of oral cGVHD. This study supports the use of the NIH OMS and its components (erythema, lichenoid and ulcerations) to measure clinician-reported severity of oral cGVHD.

show abstract

“…No âmbito das doenças não-neoplásicas a xerostomia é uma das principais repercussões das alterações nas glândulas salivares e consiste na sensação subjetiva de boca seca, consequentemente ou não à diminuição/interrupção da função das glândulas salivares em resposta a diversas causas, que englobam desde alterações psíquicas, medicamentosas, autoimunes, radioterapia, entre outras (32 …”

Section: Aspectos Da Dech Na Cavidade Oralunclassified

O envolvimento das glândulas salivares na doença do enxerto contra o hospedeiro: estudo bioquímico e análise proteômica

Antunes¹

View full text Add to dashboard Cite

How we treat oral chronic graft-versus-host disease

Cited by 80 publications

References 75 publications

Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

Oral and dental late effects in survivors of childhood cancer: a Children’s Oncology Group report

Validation of the National Institutes of Health chronic GVHD Oral Mucosal Score using component-specific measures

O envolvimento das glândulas salivares na doença do enxerto contra o hospedeiro: estudo bioquímico e análise proteômica

Contact Info

Product

Resources

About