1979
DOI: 10.1177/019262337900700204
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How Valuable is Blind Evaluation in Histopathologic Examinations in Conjunction with Animal Toxicity Studies?

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Cited by 21 publications
(21 citation statements)
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“…Informed analysis is the standard practice for the NTP, as well as the toxicologic pathology industry as a whole, and is in accordance with the recommendations of the Society of Toxicologic Pathology and the American College of Veterinary Pathologists. 5 10 The NTP’s peer review process provides a thorough review of the pathology data by highly trained pathologists using consistent terminology and criteria, and the final diagnoses in NTP studies represent a consensus between multiple, independent pathologists, providing the highest confidence in the NTP’s histopathology data and pathology review process. There is no evidence that the current approaches of informed histopathological evaluation in NTP studies have missed identifying potential hazards of significant public health concern.…”
Section: National Toxicology Program Position On Informed Analysis Fomentioning
confidence: 99%
“…Informed analysis is the standard practice for the NTP, as well as the toxicologic pathology industry as a whole, and is in accordance with the recommendations of the Society of Toxicologic Pathology and the American College of Veterinary Pathologists. 5 10 The NTP’s peer review process provides a thorough review of the pathology data by highly trained pathologists using consistent terminology and criteria, and the final diagnoses in NTP studies represent a consensus between multiple, independent pathologists, providing the highest confidence in the NTP’s histopathology data and pathology review process. There is no evidence that the current approaches of informed histopathological evaluation in NTP studies have missed identifying potential hazards of significant public health concern.…”
Section: National Toxicology Program Position On Informed Analysis Fomentioning
confidence: 99%
“…Additional factors that may alter histopathologic evaluations, include the rater's inherent skill, education, training, experience, and mental noise, as well as diurnal fluctuations in mood, nutritional state, and energy. 32 The validity of a grading scheme is ultimately assessed by its repeatability between replicate measurements wherein a kappa value between -1 and þ1 is calculated from intra-and interobserver agreement of nonparametric ordinal measurements. 8,12,24 Kappa values of -1 and þ1 correspond to perfect disagreement and perfect agreement, respectively, while 0 corresponds to no relationship between the raters such that any consensus is due to chance.…”
Section: Creating Adapting and Applying A Grading/scoring Systemmentioning
confidence: 99%
“…25 Digital scanning of all slides in a study should be performed with the same objective, typically either 20Â or 40Â, to ensure consistent resolution per pixel. 32 Excessive mounting media, haphazardly placed coverslips, and thick paraffin sections will dictate the assignment of manual focus points instead of autofocusing methods. While brightfield slide scanning is approaching routine, oil immersion lenses require Z-stacking to view the same area at different fields of focus, and fluorescent scanners essentially require separate scans for each fluorophore.…”
Section: Creating Adapting and Applying A Grading/scoring Systemmentioning
confidence: 99%
“…On the other hand, most pathologists feel that the disadvantages of "blind" pathology outweigh the advantages (19). They assert that control animals must be examined first to determine the naturally occurring incidence and severity of neoplastic and nonneoplastic lesions.…”
Section: Confounding Factorsmentioning
confidence: 99%