How trustworthy guidelines can impact outcomes

Rochwerg, Bram; Kawano-Dourado, Letícia; Qadir, Nida

doi:10.1097/mcc.0000000000000858

Cited by 4 publications

(2 citation statements)

References 24 publications

(30 reference statements)

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“…The majority of the studies reported living guideline activities conducted by the WHO (15, 71.4%),14 19 24–35 followed by China (4, 19%),36–39 Chile (1, 4.8%)40 and Lebanon (1, 4.8%) 41. All studies included in this review were published between 2019 and 2022.…”

Section: Resultsmentioning

confidence: 99%

Barriers to and facilitators of living guidelines use in low-income and middle-income countries: a scoping review

Meteku,

Quigley,

Turner

et al. 2024

BMJ Open

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IntroductionLiving guidelines provide reliable, ongoing evidence surveillance and regularly updated recommendations for healthcare decision-making. As a relatively new concept, most of the initial application of living approaches has been undertaken in high-income countries. However, in this scoping review, we looked at what is currently known about how living guidelines were developed, used and applied in low-income and middle-income countries.MethodsSearches for published literature were conducted in Medline, Global Health, Cochrane Library and Embase. Grey literature was identified using Google Scholar and the WHO website. In addition, the reference lists of included studies were checked for missing studies. Studies were included if they described or reflected on the development, application or utility of living guideline approaches for low-income and middle-income countries.ResultsAfter a full-text review, 21 studies were included in the review, reporting on the development and application of living recommendations in low-income and middle-income countries. Most studies reported living guideline activities conducted by the WHO (15, 71.4%), followed by China (4, 19%), Chile (1, 4.8%) and Lebanon (1, 4.8%). All studies based on WHO reports relate to living COVID-19 management guidelines.ConclusionsMost of the studies in this review were WHO-reported studies focusing solely on COVID-19 disease treatment living guidelines. However, there was no clear explanation of how living guidelines were used nor information on the prospects for and obstacles to the implementation of living guidelines in low-income and middle-income countries.

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Section: Resultsmentioning

confidence: 99%

Barriers to and facilitators of living guidelines use in low-income and middle-income countries: a scoping review

Meteku,

Quigley,

Turner

et al. 2024

BMJ Open

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show abstract

“…Synoptically, they attributed the favorable outcome to a profound lessening of type I interferon responses with a parallel decrease of pro-inflammatory IL-6/IL-10 ratios in tissues as well as promotion of M2 macrophage polarization [63]. Furthermore, more than 20 randomized controlled trials (RCT) [60] and eight meta-analyses [61,[64][65][66][67][68][69] have been conducted, with an overall reported conclusion being a major reduction of COVID-19 morbidity and mortality; such RCTs reported significant decreases in mortality accompanied by significant decreases in the length of viral clearance and clinical recovery. Several controlled prophylaxis trials showed a lower risk of contracting SARS-CoV-2 to be associated with regular usage of ivermectin [70].…”

Section: Covid-19 Evidence-based Treatmentsmentioning

confidence: 99%

Ofeleein i mi Vlaptin—Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic

et al. 2022

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The persistence of the coronavirus disease 2019 (COVID-19) pandemic has triggered research into limiting transmission, morbidity and mortality, thus warranting a comprehensive approach to guide balanced healthcare policies with respect to people’s physical and mental health. The mainstay priority during COVID-19 is to achieve widespread immunity, which could be established through natural contact or vaccination. Deep knowledge of the immune response combined with recent specific data indicates the potential inferiority of induced immunity against infection. Moreover, the prevention of transmission has been founded on general non-pharmacological measures of protection, albeit debate exists considering their efficacy and, among other issues, their socio-psychological burden. The second line of defense is engaged after infection and is supported by a plethora of studied agents, such as antibiotics, steroids and non-steroid anti-inflammatory drugs, antiviral medications and other biological agents that have been proposed, though variability in terms of benefits and adverse events has not allowed distinct solutions, albeit certain treatments might have a role in prevention and/or treatment of the disease. This narrative review summarizes the existing literature on the advantages and weaknesses of current COVID-19 management measures, thus underlining the necessity of acting based on the classical principle of “ofeleein i mi vlaptin”, that is, to help or not to harm.

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Concepts to support dynamic updating processes of guidelines and their practical implementation—Systematic literature review

et al. 2023

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How trustworthy guidelines can impact outcomes

Cited by 4 publications

References 24 publications

Barriers to and facilitators of living guidelines use in low-income and middle-income countries: a scoping review

Barriers to and facilitators of living guidelines use in low-income and middle-income countries: a scoping review

Ofeleein i mi Vlaptin—Volume II: Immunity Following Infection or mRNA Vaccination, Drug Therapies and Non-Pharmacological Management at Post-Two Years SARS-CoV-2 Pandemic

Concepts to support dynamic updating processes of guidelines and their practical implementation—Systematic literature review

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