How to Valorize Biodiversity? Letʼs Go Hashing, Extracting, Filtering, Mining, Fishing

Tuan, Quoc; Medina-Franco, José L.; Scior, Thomas; Bernard, Philippe

doi:10.1055/s-0034-1396314

Cited by 10 publications

(8 citation statements)

References 171 publications

(180 reference statements)

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“…NP also display a great diversity in their scaffolds (Lee and Schneider, 2001;Grabowski et al, 2008;Yongye et al, 2012). For instance, the GreenPharma database (Do et al, 2015;Gally et al, 2017) contains 55,185 Murcko frameworks (Bemis and Murcko, 1996) for 302,000 natural products (18.3%), whereas NCI and ChEMBL databases contain a little of less NP-derived scaffolds: 13.1 and 13.6% respectively.…”

Section: Limitations Related To the Need Of Market-compatible Amountsmentioning

confidence: 99%

“…de/supernatural) with more than 325,500 natural compounds, offering 3D structure and conformers (Banerjee et al, 2015) which seems to outperform many others (Harvey et al, 2015;Xie et al, 2015). Another source of natural compounds is also the Greenpharma collection (www.greenpharma.com/products/ compound-librairies/#GPNDB) (Do et al, 2015;Gally et al, 2017).…”

Section: At the Development Stage: Systematic Inventories Of Natural mentioning

confidence: 99%

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Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Lautie

Russo

Ducrot³

2020

Front. Pharmacol.

156

120

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The screening and testing of extracts against a variety of pharmacological targets in order to benefit from the immense natural chemical diversity is a concern in many laboratories worldwide. And several successes have been recorded in finding new actives in natural products, some of which have become new drugs or new sources of inspiration for drugs. But in view of the vast amount of research on the subject, it is surprising that not more drug candidates were found. In our view, it is fundamental to reflect upon the approaches of such drug discovery programs and the technical processes that are used, along with their inherent difficulties and biases. Based on an extensive survey of recent publications, we discuss the origin and the variety of natural chemical diversity as well as the strategies to having the potential to embrace this diversity. It seemed to us that some of the difficulties of the area could be related with the technical approaches that are used, so the present review begins with synthetizing some of the more used discovery strategies, exemplifying some key points, in order to address some of their limitations. It appears that one of the challenges of natural product-based drug discovery programs should be an easier access to renewable sources of plant-derived products. Maximizing the use of the data together with the exploration of chemical diversity while working on reasonable supply of natural product-based entities could be a way to answer this challenge. We suggested alternative ways to access and explore part of this chemical diversity with in vitro cultures. We also reinforced how important it was organizing and making available this worldwide knowledge in an "inventory" of natural products and their sources. And finally, we focused on strategies based on synthetic biology and syntheses that allow reaching industrial scale supply. Approaches based on the opportunities lying in untapped natural plant chemical diversity are also considered.

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Section: Limitations Related To the Need Of Market-compatible Amountsmentioning

confidence: 99%

Section: At the Development Stage: Systematic Inventories Of Natural mentioning

confidence: 99%

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Lautie

Russo

Ducrot³

2020

Front. Pharmacol.

156

120

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“…The GPDB was previously described (Do et al . 2010, 2015). It is a natural product database that includes ethnopharmacological data, folk uses, molecule structures, phytochemical properties, biochemical data and targets.…”

Section: Methodsmentioning

confidence: 99%

Development of Hinoline® as a natural preservative for cosmetic product using bioinspiration and Greenpharma Database

Bernard¹,

Saguet²,

Tuan³

et al. 2021

J Appl Microbiol

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Aims The cosmetic industry needs new preservatives that are effective, natural, safe, cost effective, sustainable and compliant with regulatory standards. This necessity has posed challenges requiring obligations, bioinformatics and bioinspiration as driving forces. Methods and results Twenty natural extracts were selected from the Greenpharma Database with parameter filters corresponding to development constraints and antimicrobial properties. We confirmed using minimum inhibition concentration (MIC) assays that eight of the extracts have good bactericidal properties and that one has a high antifungal activity. The latter was purified hinokitiol, a bioproduct from Aomori Hiba wood. This substance provides high resistance against putrefaction; for instance, old Japanese temples were made of Aomori Hiba wood. The combination of hinokitiol with levulinic acid, another bioproduct, demonstrated complementary antimicrobial activities and synergistic effects in MIC studies and measurements according to Kull synergy index. Further, the mixture Hinoline® was tested at 2% in challenge tests and fulfilled criteria A of different standards. It also exerted complementary preservative effects with potassium sorbate and beneficial effects in unbalanced skin microbiota. Conclusion Hinoline, a new effective preservative from renewable bioresources, was developed. Significance and Impact of the Study This study accelerates the development of a preservative solution for cosmetics selected from Greenpharma Database, through bioinspiration and the identification of cost‐effective investments and resources.

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“…Over the following 5 years, it is envisioned that more countries in Latin America integrate their databases in LANaPD. It is also expected that such a unified database is being actively used in data mining, virtual screening, and other artificial intelligence applications [ 23 ].…”

Section: Future Perspectivementioning

confidence: 99%

Towards a Unified Latin American Natural Products Database: LANaPD

Medina-Franco

2020

Future Sci. OA

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Around the world, the number of compound databases of natural products in the public domain is rising. This is in line with the increasing synergistic combination of natural product research and chemoinformatics. Toward this global endeavor, countries in Latin America are assembling, curating, and analyzing the contents and diversity of natural products available in their geographical regions. In this manuscript we collect and analyze the efforts that countries in Latin America have made so far to build natural product databases. We further encourage the scientific community in particular in Latin America, to continue their efforts to building quality natural product databases and, whenever possible, to make them publicly accessible. It is proposed that all compound collections could be assembled into a unified resource called LANaPD: Latin American Natural Products Database. Opportunities and challenges to build, distribute and maintain LANaPD are also discussed.

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How to Valorize Biodiversity? Letʼs Go Hashing, Extracting, Filtering, Mining, Fishing

Cited by 10 publications

References 171 publications

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

Development of Hinoline® as a natural preservative for cosmetic product using bioinspiration and Greenpharma Database

Towards a Unified Latin American Natural Products Database: LANaPD

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