How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

Santonen, Tiina; Mahiout, Selma; Alvito, Paula; Apel, Petra; Bessems, Jos; Bil, Wieneke; Borges, Teresa; Böse‐O'Reilly, Stephan; Buekers, Jurgen; Cañas, Ana; Castaño, Argelia; González, Mercedes de Alba; Domínguez-Morueco, Noelia; Esteban, Marta; Falnoga, Ingrid; Gerofke, Antje; Caballero, María del Carmen González; Horvat, Milena; Huuskonen, Pasi; Kadikis, Normunds; Kolossa-Gehring, Marike; Lange, Rosa; Louro, Henriqueta; Martins, Carla; Meslin, Matthieu; Niemann, Lars; Pedraza-Dı́az, Susana; Plichta, Veronika; Porras, Simo P.; Rousselle, Christophe; Scholten, Bernice; Silva, Maria João; Šlejkovec, Zdenka; Tratnik, Janja Snoj; Joksić, Agnes Šömen; Tarazona, José V.; Uhl, Maria; Nieuwenhuyse, An Van; Viegas, Susana; Vinggaard, Anne Marie; Woutersen, Marjolijn; Schoeters, Greet

doi:10.1016/j.ijheh.2023.114139

Cited by 8 publications

(3 citation statements)

References 93 publications

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“…Another is the use of several methods (food diary, questionnaire, accelerometer, and biomonitoring) giving detailed information about dietary habits, food intake, exposure, and nutrient status. The biomonitoring part is unique in its inclusion of a national representative sample of young children and of particular interest because biomonitoring of toxic compounds has received increased attention as an important tool to support risk assessment, and chemical policy and regulation [ 35 , 36 ]. Further, because we have assessed food consumption both at home and in preschools, we have the possibility to investigate the impact of preschools on food quality and socioeconomic discrepancies in food habits.…”

Section: Discussionmentioning

confidence: 99%

Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey

Bjermo,

Patterson,

Petrelius Sipinen

et al. 2024

Current Developments in Nutrition

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Section: Discussionmentioning

confidence: 99%

Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey

Bjermo,

Patterson,

Petrelius Sipinen

et al. 2024

Current Developments in Nutrition

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“…The results of the present study should be interpreted considering some possible limits, such as the potentially small and nonrepresentative sample, uncontrolled effect modifiers or confounding, selection bias, historical perspective, as well as missing exact biomarkers of exposure. However, human biomonitoring remains the best approach for evaluating the effects of complex mixtures, providing data for further in vitro and in silico studies, and scientifically based risk assessment [ 72 , 73 , 74 , 75 ]. Recent studies suggest that sentinel organisms such as butterflies and plants, sensitive to air pollutants, could serve as early warning signs for human biomonitoring studies [ 76 , 77 , 78 , 79 ].…”

Section: Discussionmentioning

confidence: 99%

Air Pollution and Primary DNA Damage among Zagreb (Croatia) Residents: A Cross-Sectional Study

Gerić,

Pehnec,

Matković

et al. 2024

JoX

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More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world’s population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution data among 123 participants enrolled between 2011 and 2015 in Zagreb, Croatia. While most measured air pollutants adhered to regulatory limits, benzo[a]pyrene concentrations bound to PM10 exceeded them. Factorial analysis narrowed down air pollution data to four exposure factors (particulate matter, two metal factors, and other pollutants). Despite the absence of significant positive associations between modeled air pollution exposure factors and comet assay descriptors (tail length, tail intensity, tail moment, and highly damaged nuclei), the critical health implications of air pollution warrant further investigations, particularly with biomarkers of exposure and different biomarkers of effect in populations facing air pollution exposure.

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“…Pyrethroids are frequently included in human biomonitoring as studies on pesticides [ 17 ]. The use of human biomonitoring for realistic risk assessment offers clear advantages [ 18 ], but as previously reported, the metabolic profile of pyrethroids requires specific considerations [ 9 ]. While the common metabolites associated with the 3-phenoxybenzyl alcohol moiety facilitate screening assessments [ 19 ], the lack of unique urinary metabolites adds complexity for refining the risk, triggering our previous proposal for a tiered approach [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations

de Alba-Gonzalez,

González-Caballero,

Tarazona

2023

Toxics

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The use of pyrethroids is very broad and shows increasing trends. Human biomonitoring studies represent the best approach for realistic risk estimations, but their interpretation requires a tiered approach. A previous HBM4EU study indicated levels in European children groups just around the threshold for concern, requiring further refinement. The main difficulty is that several pyrethroids with different toxicity potencies generate the same urinary metabolites. As diet is the main pyrethroid source for the general population, EU food monitoring data reported by EFSA have been used to estimate the relative contribution of each pyrethroid. The main contributors were cypermethrin for DCCA and 3-PBA and lambda-cyhalothrin for CFMP. Urinary levels predicted from food concentration according to the EFSA diets were mostly within the range of measured levels, except 3-PBA and CFMP levels in children, both below measured levels. The predicted lower levels for 3-PBA can be explained by the very low Fue value, initially proposed as conservative, but that seems to be unrealistic. The discrepancies for CFMP are mostly for the highest percentiles and require further assessments. The refined assessments included the revision of the previously proposed human biomonitoring guidance values for the general population, HBM-GV Gen Pop, following recent toxicological reevaluations, and the estimation of hazard quotients (HQs) for each individual pyrethroid and for the combined exposure to all pyrethroids. All HQs were below 1, indicating no immediate concern, but attention is required, particularly for children, with HQs in the range of 0.2–0.3 for the highly exposed group. The application of probabilistic methods offers assessments at the population level, addressing the variability in exposure and risk and providing relevant information for Public Health impact assessments and risk management prioritization.

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How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

Cited by 8 publications

References 93 publications

Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey

Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey

Air Pollution and Primary DNA Damage among Zagreb (Croatia) Residents: A Cross-Sectional Study

Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations

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