How to Treat Osteochondritis Dissecans of the Knee: Surgical Techniques and New Trends

Kon, Elizaveta; Vannini, Francesca; Buda, Roberto; Filardo, Giuseppe; Cavallo, Marco; Ruffilli, Alberto; Nanni, Matteo; Martino, Alessandro Di; Marcacci, Maurilio; Giannini, Sandro

doi:10.2106/jbjs.k.00748

Cited by 51 publications

(63 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kon et al [21] showed that multilayer collagen/nanohydroxyapatite scaffolds promoted bone and cartilage tissue restoration. Nevertheless, improvement in the mechanical properties/stability of bilayered scaffold and optimization of the incorporation of bioactive factors in the scaffolds are still big challenges [17,24,25]. Other problems are related to achieving a good interface between the different layers [26].…”

Section: Introductionmentioning

confidence: 99%

Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance

et al. 2015

View full text Add to dashboard Cite

Novel porous bilayered scaffolds, fully integrating a silk fibroin (SF) layer and a silk-nano calcium phosphate (silk-nanoCaP) layer for osteochondral defect (OCD) regeneration, were developed. Homogeneous porosity distribution was achieved in the scaffolds, with calcium phosphate phase only retained in the silk-nanoCaP layer. The scaffold presented compressive moduli of 0.4MPa in the wet state. Rabbit bone marrow mesenchymal stromal cells (RBMSCs) were cultured on the scaffolds, and good adhesion and proliferation were observed. The silk-nanoCaP layer showed a higher alkaline phosphatase level than the silk layer in osteogenic conditions. Subcutaneous implantation in rabbits demonstrated weak inflammation. In a rabbit knee critical size OCD model, the scaffolds firmly integrated into the host tissue. Histological and immunohistochemical analysis showed that collagen II positive cartilage and glycosaminoglycan regeneration presented in the silk layer, and de novo bone ingrowths and vessel formation were observed in the silk-nanoCaP layer. These bilayered scaffolds can therefore be promising candidates for OCD regeneration.

show abstract

Section: Introductionmentioning

confidence: 99%

Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Porous bone scaffolds promote the bone growth and can serve as carrier for drugs and stem cells (Ma et al, 2015;Mravic, Peault, & James, 2014). In addition to the application for structural bone restoration, multilayered scaffolds could also be used to support the tissue healing in case of chondral and osteochondral defects, for example, of knee lesions (Delcogliano et al, 2014;Kon et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

View full text Add to dashboard Cite

Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

show abstract

“…A review by Kon et al 12 summarised different effective surgical techniques to manage femoral condyle OCD. They discussed massive osteochondral autologous transplantation that involves shaping up the defect and press-fitting a squared contoured graft into the recipient bed.…”

Section: Discussionmentioning

confidence: 99%

An uncommon chronic osteochondral defect in the lateral tibial plateau detected after a separate injury

Leung¹,

2018

BMJ Case Reports

View full text Add to dashboard Cite

Osteochondral defects (OCD) are rare conditions that usually present in young adolescents. The causes include trauma, inflammation, ischaemia, genetics and changes at secondary ossification centres. The case report presents a 27-year-old man with chronic intermittent left knee pain for about 3 years. He typically develops the symptom after prolonged standing or when rising from a prolonged seated position. An initial MRI scan in 2014 did not identify and report an OCD that was present in his left lateral tibial plateau. It was only after an accidental tibial fracture injury this year that the defect was incidentally detected on a scan. OCD can be staged based on MRI and/or arthroscopic findings. The treatment can be either non-operative or operative, but this largely depends on the age of the patient, the severity of symptoms and the staging of the defect.

show abstract

How to Treat Osteochondritis Dissecans of the Knee: Surgical Techniques and New Trends

Cited by 51 publications

References 22 publications

Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance

Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance

Development of magnesium implants by application of conjoint‐based quality function deployment

An uncommon chronic osteochondral defect in the lateral tibial plateau detected after a separate injury

Contact Info

Product

Resources

About