How to Treat Cytomegalovirus-induced Hemophagocytic Lymphohistiocytosis in a Child With Leukemia

Eldem, İrem; Al-Rahawan, Mohamad M.; Levent, Fatma

doi:10.1097/mph.0000000000001547

Cited by 3 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Symptomatic CMV infection was reported in 28 patients (19 boys, 9 girls; median age 8.5 years, range, 1‐15 years; Table 1). 10‐30 All but one patient suffered from ALL, and one patient had relapsed AML. The infection occurred in most of the patients ( n = 22) during maintenance therapy, and main symptoms were persisting fever not to be explained by other causes (19 patients), visual disturbances (10 patients), acute visual loss (one patient) or retinitis (two patients), pancytopenia (six patients) or hepatomegaly (eight patients).…”

Section: Resultsmentioning

confidence: 99%

Systemic viral infection in children receiving chemotherapy for acute leukemia

Buus-Gehrig

Bochennek

Hennies

et al. 2020

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Systemic viral diseases frequently occur in allogeneic hematopoietic stem cell transplantation, but data in children receiving chemotherapy for acute leukemia are scarce. We therefore collected and analyzed the published data on symptomatic infection from cytomegalovirus, herpes simplex virus, varicella zoster virus, parvovirus B19, or adenovirus in pediatric acute leukemia. Reports on 68 children were identified, of whom 16 patients have died from the infection. Further studies have to (1) evaluate the true incidence of these infections in pediatric acute leukemia, (2) their impact on outcome, and (3) whether a subpopulation of patients could benefit from screening and prophylactic strategies. K E Y W O R D S acute leukemia, adenovirus, child, cytomegalovirus, herpes simplex virus, parvovirus B19, systemic viral disease, varicella zoster virus We performed a MEDLINE (including MEDLINE In Process) search to identify relevant English-language articles indexed from January 1, 2000, up to December 31, 2019. The search included a combination of indexed terms and free text terms (child OR adolescent OR pediatr*); (cancer OR malignancy OR leukemia); (parvovirus OR b19)/(adenovirus)/(varicella or VZV)/(cytomegalovirus or CMV)/(herpes simplex virus or HSV). The hits were screened manually by two of the authors (CBG and TL). Only case reports and case series about systemic infections or studies on the prevalence of viremia with CMV, HSV, VZV, PVB19, and ADV, respectively, occurring in children

show abstract

Section: Resultsmentioning

confidence: 99%

Systemic viral infection in children receiving chemotherapy for acute leukemia

Buus-Gehrig

Bochennek

Hennies

et al. 2020

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

“…Cytomegalovirus (CMV) is typical of newborns and immunocompromised patients (72,73,(77)(78)(79)(80)(81) and so is the varicella zoster virus (82). Dengue virus plays a significant role in tropical countries (73,(83)(84)(85)(86)(87)(88)(89)(90).…”

Section: Classificationmentioning

confidence: 99%

Secondary hemophagocytic lymphohistiocytosis in children (Review)

et al. 2023

View full text Add to dashboard Cite

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition characterized by hyperinflammation in an uncontrolled and ineffective immune response. Despite great improvement in diagnosis and treatment, it still represents a challenge in clinical management, with poor prognosis in the absence of an aggressive therapeutic approach. The present literature review focuses on secondary HLH at pediatric age, which represents a heterogeneous group in terms of etiology and therapeutic approach. It summarizes the most recent evidence on epidemiology, pathophysiology, diagnosis, treatment and prognosis, and provides a detailed description and comparison of the major subtypes of secondary HLH. Finally, it addresses the open questions with a focus on diagnosis and new treatment insights.

show abstract

“…We read with interest the article by Eldem et al 1 We would like to share our experience with a patient who developed cytomegalovirus-(CMV) associated hemophagocytosis while receiving maintenance acute lymphoblastic leukemia (ALL) therapy.…”

Section: Cytomegalovirusrelated Hemophagocytosis In Childhood Acutementioning

confidence: 99%