How to Stabilize the Level of lonized Calcium and Citrate during Plateletpheresis

Farrokhi, P.; Farahmand, H; Bismuth, A; Suárez, Cinta Prieto; Ducot, B.; Gillon, Marina; Debat, Pierre; Laskowski, P.; Pinon, F

doi:10.1046/j.1423-0410.1998.7410007.x

Cited by 11 publications

(1 citation statement)

References 21 publications

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“…[ 27 ] Other studies also reported that although, the fall in tCa ++ and tMg ++ were modest and not significant, the drop in iCa and iMg was statistically significant ( P < 0.001). [ 1 25 28 ]…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of changes in clinically significant divalent serum cation levels during automated plateletpheresis in healthy donors in a tertiary care center in North India

Solanki

Agarwal

2015

Asian J Transfus Sci

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Background:Adverse effects due to apheresis are unusual. The most common apheresis-specific reaction is hypocalcemia due to citrate anticoagulation and induces ionized hypocalcemia and hypomagnesemia by chelating effect during the plateletpheresis; generally transient and self-limiting but has the potential of severely injuring donor. We have investigated total calcium (tCa++) and magnesium (tMg++) levels in sixty healthy plateletpheresis donors at different intervals during the procedure and 30 min post-procedure.Materials and Methods:A total of 60 procedures were performed on healthy donors. Blood samples were obtained from sterile diversion pouch placed on apheresis circuit. 5 ml sample in plain vials was obtained at different intervals during each procedure and 30 min after the end of the procedure. Samples were used for measurement of tCa++ and tMg++ levels.Results:There is continuous decrease in mean tCa++ from baseline levels (9.83 ± 0.64 mg/dl) till end of procedure (8.33 ± 0.78 mg/dl), but after 30 min, levels again reached near their respective baseline values (9.42 ± 0.54 mg/dl). Similarly, mean tMg++ fell from baseline levels (2.36 ± 0.3 mg/dl) till the end of procedure (1.39 ± 0.40 mg/dl). After 30 min, levels were again increased, their respective baseline values (2.25 ± 0.25 mg/dl).Conclusion:There is continuous, gradual, and significant fall (P < 0.05) in mean tCa++ and mean tMg++ from baseline levels to till the end of procedure but after 30 min of completion of procedure, levels again reached near their respective baseline values.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of changes in clinically significant divalent serum cation levels during automated plateletpheresis in healthy donors in a tertiary care center in North India

Solanki

Agarwal

2015

Asian J Transfus Sci

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Electrolyte monitoring in patients undergoing peripheral blood stem cell collection

et al. 1999

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Clinically relevant hypokalaemia, hypocalcaemia, and loss of hemoglobin and platelets during stem cell apheresis

Schlenke¹,

Frohn²,

Steinhardt³

et al. 2000

J. Clin. Apheresis

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How to Stabilize the Level of lonized Calcium and Citrate during Plateletpheresis

Abstract: With this stepdown citrate reduction protocol, we obtained a significant reduction of injected citrate without the complication of platelet clumps.

Cited by 11 publications

References 21 publications

Comprehensive analysis of changes in clinically significant divalent serum cation levels during automated plateletpheresis in healthy donors in a tertiary care center in North India

Comprehensive analysis of changes in clinically significant divalent serum cation levels during automated plateletpheresis in healthy donors in a tertiary care center in North India

Electrolyte monitoring in patients undergoing peripheral blood stem cell collection

Clinically relevant hypokalaemia, hypocalcaemia, and loss of hemoglobin and platelets during stem cell apheresis

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