How to spot a basosquamous carcinoma: a study on demographics, clinical-dermatoscopic features and histopathological correlations

Sgouros, Dimitrios; Apalla, Zoé; Theofili, Melpomeni; Damaskou, Vasileia; Kokkalis, G.; Kitsiou, Eftichia; Lallas, Aimilios; Κανελλέας, Αντώνιος; Stratigos, Alexander J.; Nikolaidou, Christina; Bobos, Mattheos; Panayiotides, Ioannis G.; Rigopoulos, Dimitrios; Katoulis, Alexander

doi:10.1684/ejd.2021.4178

Cited by 6 publications

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“…We found that infiltrative BCC is usually not pigmented and typified by the presence of arborizing vessels, shiny white structures and ulceration, in line with previous studies [ 15 , 16 , 17 ]. Interestingly, in a recent metanalysis by Reiter et al, the dermoscopic features of 288 infiltrative BCCs were analyzed, and the outcomes were the followings: arborizing vessels were present in 76% of the tumors (95% CI 59−77%), ulceration in 44% (95% CI 26−62%), and short fine telangiectasis in 40% of cases (95% CI 27−53%) [ 15 ].…”

Section: Discussionsupporting

confidence: 93%

“…These findings are in moderate consistency with the previous literature. In detail, our results are similar to those reported by Sgouros et al, with arborizing vessels being present in 88% of cases, ulceration/erosion in 72%, and superficial scales, keratin mass, shiny white structures in more than half (56%) [ 17 ]. Notably, the majority of the 22 metatypical carcinomas analyzed were non-pigmented (60%) in accordance with our data [ 16 ].…”

Section: Discussionsupporting

confidence: 91%

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Dermoscopic Clues of Histopathologically Aggressive Basal Cell Carcinoma Subtypes

et al. 2023

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Background: The group of histopathologically aggressive BCC subtypes includes morpheaform, micronodular, infiltrative and metatypical BCC. Since these tumors are at increased risk of recurring, micrographically controlled surgery is considered the best therapeutic option. Although dermoscopy significantly improves the clinical recognition of BCC, scarce evidence exists on their dermoscopic criteria. Aim: To investigate the dermoscopic characteristics of histopathologically aggressive BCC subtypes. Materials and Methods: Dermoscopic images of morpheaform, micronodular, infiltrative and metatypical BCC were analyzed for the presence of predefined variables. Descriptive and analytical statistics were performed. Results: Most histopathologically aggressive BCCs were located on the head and neck. Infiltrative was the most common subtype. All subtypes, except micronodular BCC, rarely displayed dermoscopic pigmentation. The most frequent dermoscopic features of infiltrative BCC were arborizing vessels (67.1%), shiny white structures (48.6%) and ulceration (52.9%). The features prevailing in morpheaform BCC were arborizing vessels (68.4%), ulceration (n = 12, 63.2%) and white porcelain areas (47.4%). Micronodular BCC was typified by milky red structureless areas (53.8%), arborizing vessels (53.8%), short fine telangiectasias (50%), ulceration (46.2%) and blue structures (57.7%). The most common findings in metatypical BCC were arborizing vessels (77.8%), shiny white structures (66.7%), ulceration (62.9%) and keratin mass (29.6%). Limitations: Study population of only white skin and relatively small sample size in some groups. Conclusions: Our study provided data on the clinical, dermoscopic and epidemiological characteristics of histopathologically aggressive BCCs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Dermoscopic Clues of Histopathologically Aggressive Basal Cell Carcinoma Subtypes

et al. 2023

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“…However, occasional misclassifications of BSC as Basal Cell Carcinoma (BCC) or Squamous Cell Carcinoma (SCC) have been reported, frequently due to nonrepresentative biopsies of deeply located tumors. In this context, noninvasive skin imaging plays a crucial role in both improving BSC recognition and optimizing subsequent followup strategies [22][23][24][25][26][27][28].…”

Section: Diagnosis Of Basosquamous Carcinomamentioning

confidence: 99%

Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches

Murgia,

Denaro,

Boggio

et al. 2023

Cells

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Basosquamous carcinoma (BSC), an uncommon and aggressive nonmelanoma skin cancer exhibiting characteristics ranging from basal cell carcinoma (BCC) to squamous cell carcinoma (SCC), is a subject of controversy in terms of its classification, pathogenesis, histologic morphology, biologic behavior, prognosis, and management. This narrative review is based on an electronic search of English-language articles in PubMed that included the terms “basosquamous carcinoma” and/or “metatypical carcinoma of the skin” in their titles. The review aims to succinctly present and assess current data on the epidemiology, clinical presentation, dermoscopic, LC-OCT, and histopathologic characteristics, as well as the genetics and management of BSC, providing insight into this intriguing entity. As a conclusion, dermoscopy, deep incisional biopsies, and immunohistologic techniques should be applied in clinically suspicious lesions to achieve an early diagnosis and better prognosis of this tumor. Surgical treatments, including wide excision and Mohs’ micrographic surgery, remain the treatment of choice. Finally, Hedgehog pathway inhibitors and checkpoint inhibitors, must be thoroughly investigated with large controlled trials, since they may offer an alternative solution to irresectable or difficult-to-treat locally advanced cases of basosquamous carcinoma.

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Common Skin Cancers in Older Adults Approach to Diagnosis and Management

Council,

Sheinbein

2024

Clinics in Geriatric Medicine

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How to spot a basosquamous carcinoma: a study on demographics, clinical-dermatoscopic features and histopathological correlations

Cited by 6 publications

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Dermoscopic Clues of Histopathologically Aggressive Basal Cell Carcinoma Subtypes

Dermoscopic Clues of Histopathologically Aggressive Basal Cell Carcinoma Subtypes

Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches

Common Skin Cancers in Older Adults Approach to Diagnosis and Management

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