How to run biotransformations⿿At the optimal temperature control or isothermally? Mathematical assessment

Grubecki, I.

doi:10.1016/j.jprocont.2016.05.005

Cited by 6 publications

(4 citation statements)

References 46 publications

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“…The parameters obtained for deactivation of Aspergillus niger catalase by hydrogen peroxide can be used in modeling and optimization of batch bioreactors (Grubecki, 2016;Vasić-Rački et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

“…The present studies were conducted with the concentration of hydrogen peroxide lower than 0.015 mol/L at temperatures ranging from 35ºC to 50ºC. The obtained parameters for deactivation of Aspergillus niger catalase by hydrogen peroxide can be used in modeling and optimization of batch bioreactors (Grubecki, 2016;Vasić-Rački et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Estimation of the Kinetic Parameters for H2o2 Enzymatic Decomposition and for Catalase Deactivation

Miłek

2018

Braz. J. Chem. Eng.

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Catalase is a potentially useful biocatalyst in various industrial bioprocesses (textile industry, food processing, and pulp and paper) that require removal of hydrogen peroxide. This process can be achieved in such reactors even under isothermal conditions. However, it is usually connected with a long duration of the process or with spending a considerable amount of biocatalyst for a unit mass of the transformed substrate, which in turn leads to an increase in operating costs. They can be limited by applying the optimal temperature control, which requires the values of the thermodynamic parameters-the activation energy for reaction and the activation energy for deactivation must be known. This work reports these parameters for hydrogen peroxide decomposition and Aspergillus niger catalase deactivation at temperatures ranging from 35°C to 50°C.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estimation of the Kinetic Parameters for H2o2 Enzymatic Decomposition and for Catalase Deactivation

Miłek

2018

Braz. J. Chem. Eng.

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“…Temperature, besides feed flow rate, is the most important decisive variable in flow (bio)reactors [15,[50][51][52][53][54]. It has a crucial impact on enzyme activity, its stability, and in consequence on bioreactor performance [6].…”

Section: Optimization Problem Formulationmentioning

confidence: 99%

“…35Additionally-in case of bioprocesses-assurance of the optimal conditions assurance can be a very challenging task because of enzyme deactivation. Such a phenomenon takes place as the factors responsible for this process characteristics can be decisive in choosing the reactor operating mode and optimal operating strategy for the biotransformations course [15][16][17][18]. Biocatalyst deactivation dependent on the substrate concentration (parallel deactivation) is a specific mechanism of deactivation and is related to catalase.…”

Section: Introductionmentioning

confidence: 99%

Analytical Determination of the Optimal Feed Temperature for Hydrogen Peroxide Decomposition Process Occurring in Bioreactor with a Fixed-Bed of Commercial Catalase

Grubecki

2020

Catalysts

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The hydrogen peroxide-immobilized commercial catalase system was chosen to estimate the optimal feed temperature (OFT) for fixed-bed reactor (FXBR). This feed temperature was obtained based on analytical solution by maximizing the time-averaged substrate conversion under a constant feed flow rate and temperature constraints. In calculations a set of partial differential equations describing the conservation equation for fixed-bed reactor, assuming plug flow and kinetic equation for the rate of enzyme parallel deactivation was taken into account. The model is based on kinetic, and mass-transfer parameters estimated previously in a real decomposition process of hydrogen peroxide (HP). The simulation showed that the OFT is strongly dependent on hydrogen peroxide feed concentration, feed flow rate and diffusional resistances expressed by biocatalyst global effectiveness factor. It has been shown that the more significant diffusional resistances and the higher HP conversions are, the higher the optimal feed temperature is. The calculated values of the OFT were verified with the experimental results obtained in the model reactor at selected values of the feed flow rate. Presented analysis poses a significant simplification in a numerical computational procedure and can be very useful for engineers to select the temperature condition at which bioreactor productivity is expected to be maximal.

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Optimal Feed Temperature for Hydrogen Peroxide Decomposition Process Occurring in the Reactor with Fixed-Bed of Commercial Catalase

Grubecki

Zalewska

2018

EngOpt 2018 Proceedings of the 6th International Conference on Engineering Optimization

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How to run biotransformations⿿At the optimal temperature control or isothermally? Mathematical assessment

Cited by 6 publications

References 46 publications

Estimation of the Kinetic Parameters for H2o2 Enzymatic Decomposition and for Catalase Deactivation

Estimation of the Kinetic Parameters for H2o2 Enzymatic Decomposition and for Catalase Deactivation

Analytical Determination of the Optimal Feed Temperature for Hydrogen Peroxide Decomposition Process Occurring in Bioreactor with a Fixed-Bed of Commercial Catalase

Optimal Feed Temperature for Hydrogen Peroxide Decomposition Process Occurring in the Reactor with Fixed-Bed of Commercial Catalase

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