How to overcome male infertility after 40: Influence of paternal age on fertility

Belloc, S.; Hazout, A.; Zini, Armand; Merviel, Philippe; Cabry, Rosalie; Chahine, Hikmat; Copin, Henri; Benkhalifa, Moncef

doi:10.1016/j.maturitas.2014.02.011

Cited by 89 publications

(63 citation statements)

References 157 publications

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“…The decline in male fertility with age is a well-accepted concept [9]. The reasons given are many involving impairment of sperm parameters to genomic alterations of the sperm with age [10]. Those reasons are amplified by an alteration of sperm parameters recorded in the last two decades [6].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and Clinical Profile of Male Hypofertility in Consultation at the Urology-Andrology of Yalgado Ouedraogo Teaching Hospital (Burkina Faso)

Kirakoya¹,

Zango²,

Karim³

et al. 2015

ASM

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Section: Discussionmentioning

confidence: 99%

Epidemiological and Clinical Profile of Male Hypofertility in Consultation at the Urology-Andrology of Yalgado Ouedraogo Teaching Hospital (Burkina Faso)

Kirakoya¹,

Zango²,

Karim³

et al. 2015

ASM

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“…Age of the father has been implicated in reducing the rates of ART fertilization, implantation, pregnancy, and live birth [10,21,22] although these results are not found consistently [9]. Other studies have linked paternal age to increased miscarriage rates [8], as well as birth defects and autism [11-15, 21, 23].…”

Section: Discussionmentioning

confidence: 99%

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Stern

Luke

Hornstein

et al. 2014

J Assist Reprod Genet

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Purpose To compare ages of mothers and of fathers at delivery in couples who are fertile, subfertile, and subfertile treated with assisted reproductive technology (ART) and to characterize birth outcomes in the ART population according to paternal age. Methods Live birth deliveries in Massachusetts between July, 2004 and December, 2008 were identified from vital records and categorized by maternal fertility status and treatment as ART, subfertile or fertile. The ART births were linked to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System (SART CORS) database to obtain cycle-specific treatment data. Parental ages were obtained from birth certificates. Age of mothers and fathers were compared using ANOVA for continuous measures and χ 2 for categories. Risks of prematurity (<37 weeks), low birthweight (<2,500 g), and low birthweight z-score (small for gestatational age, SGA) were modeled using logistic regression by categories of paternal age as adjusted odds ratios and 95 % CI. Results The study population included 9,092 ART, 6,238 subfertile, and 318,816 fertile deliveries. Paternal ages in the ART and subfertile groups were similar and differed significantly from those of the fertile group. Maternal age in the ART and subfertile groups averaged 5-6 years older than their fertile counterparts and fathers averaged 4-5 years older with twice as many being older than 37. The risks for prematurity, low birthweight and SGA did not increase with increasing paternal age. Conclusions Fathers in ART-treated and subfertile couples are older than in their fertile counterparts. Older paternal age was not assoicated with increased risk for prematurity, low birthweight, or SGA.

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“…Given that age is expected to have a significant role in both male and female infertility diagnosis (Belloc, Hazout, Zini, Merviel, Cabry, Chahine, Copin & Benkhalifa,, 2014;Bretherick, Fairbrother, Avila, Harbord & Robinson,, 2010), we controlled for age in both models (step 1). Mean degree of stress attributed to both childhood/adolescence and adulthood life events were entered as independent variables in step 2.…”

Section: Statistical Analysesmentioning

confidence: 99%

Effects of life events on infertility diagnosis: comparison with presumably fertile men and women

Santos

Sobral

Martins

2016

Journal of Reproductive and Infant Psychology

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How to overcome male infertility after 40: Influence of paternal age on fertility

Cited by 89 publications

References 157 publications

Epidemiological and Clinical Profile of Male Hypofertility in Consultation at the Urology-Andrology of Yalgado Ouedraogo Teaching Hospital (Burkina Faso)

Epidemiological and Clinical Profile of Male Hypofertility in Consultation at the Urology-Andrology of Yalgado Ouedraogo Teaching Hospital (Burkina Faso)

The effect of father’s age in fertile, subfertile, and assisted reproductive technology pregnancies: A population based cohort study

Effects of life events on infertility diagnosis: comparison with presumably fertile men and women

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