How to measure bacterial genome plasticity? A novel time-integrated index helps gather insights on pathogens
Greta Bellinzona,
Gherard Batisti Biffignandi,
Fausto Baldanti
et al.
Abstract:Genome plasticity can be defined as the capacity of a bacterial population to swiftly gain or lose genes. The time factor plays a fundamental role for the evolutionary success of microbes, particularly when considering pathogens and their tendency to gain antimicrobial resistance factors under the pressure of the extensive use of antibiotics. Multiple metrics have been proposed to provide insights into the gene content repertoire, yet they overlook the temporal component, which has a critical role in determini… Show more
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