How to Measure a Growing Hemangioma and Assess Response to Therapy

Tsang, Matthew; Garzon, María C.; Frieden, Ilona J.

doi:10.1111/j.1525-1470.2006.00216.x

Cited by 26 publications

(32 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traditionally, infantile haemangiomas have been difficult to quantitatively assess because of their irregularity, variable elevation [3], and propensity to be located on contoured regions such as the head and neck [13]. Because of these factors, traditional physical measures are often inaccurate and can vary markedly between assessors and even between the same assessors over time.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the irregular, three-dimensional nature of these lesions, simple clinical measures utilising rulers and callipers can at best provide an estimate of volume [3]. In contrast, imaging techniques such as magnetic resonance imaging (MRI) and computed tomography (CT) can provide extremely precise measures of volume but are limited by expense, radiation exposure [4] and the need for infants to remain entirely still (often necessitating sedation) to perform these studies [5].…”

mentioning

confidence: 99%

See 1 more Smart Citation

3D photography is a reliable method of measuring infantile haemangioma volume over time

Robertson

Kimble

Storey

et al. 2016

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

3D photography is a reliable method of measuring infantile haemangioma volume over time

Robertson

Kimble

Storey

et al. 2016

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…The hemispheric measurement is a bedside method to calculate the size of the IH using the following equation: (½) V=0.07 m 3 , where m is the average of the maximum length and maximum width of the lesion [20]. Photographs and dimensions of the IHs were taken at each visit.…”

Section: Follow-up and Endpoints Of The Studymentioning

confidence: 99%

Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Response to therapy was measured by (1) blinded predicted volume estimation 25 at weeks 0, 1, 2, 3, 4, 8, 12, 16, 20, and 24 and (2) blinded scoring of clinical photographs at 0, 12, and 24 weeks. For volume estimation, 2 measurements of the IH hemispheric diameter were taken 90°apart and the estimated hemispheric volume was calculated by the formula 0.07 3 m 3 where m is the mean of the 2 hemispheric measurements.…”

Section: Outcome Measuresmentioning

confidence: 99%

“…For volume estimation, 2 measurements of the IH hemispheric diameter were taken 90°apart and the estimated hemispheric volume was calculated by the formula 0.07 3 m 3 where m is the mean of the 2 hemispheric measurements. 25 The photographs at 0, 12, and 24 weeks were scored by 1 blinded investigator as 0 if no redness was observable, 1 if the lesion was ∼50% red, or 2 if the lesion was completely red.…”

Section: Outcome Measuresmentioning

confidence: 99%

RCT of Timolol Maleate Gel for Superficial Infantile Hemangiomas in 5- to 24-Week-Olds

Chan¹,

McKay²,

Adams

et al. 2013

Pediatrics

131

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT:The systemic nonselective b-blocker propranolol hydrochloride is increasingly used as firstline management for infantile hemangiomas. Superficial nonulcerating lesions do not require systemic medications. Case series have suggested the efficacy of timolol; however, its safety has been questioned. WHAT THIS STUDY ADDS:This randomized controlled trial indicates that timolol maleate 0.5% gel is a well-tolerated, safe, and effective treatment of superficial infantile hemangiomas. abstract OBJECTIVE: Timolol maleate 0.5% gel is a safe and effective medication for treating superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks.METHODS: Forty-one infants who had superficial IHs without ulceration and not near mucosal surfaces were recruited and randomly assigned to placebo and treatment (timolol maleate 0.5% gel) groups. Efficacy was assessed by performing blinded volume measurements at weeks 0, 1, 2, 3,4,8,12,16,20, and 24 and blinded investigator photograph scoring at weeks 0, 12, and 24. Safety was assessed by measuring heart rate and systolic and diastolic blood pressure at weeks 0, 1, 2, 3, 4, 8, 12, 16, 20, and 24. RESULTS: Fifteen of the 19 infants receiving treatment and 17 of the 22 infants receiving placebo completed the study. Significant color change on the blinded photographic scores was noted at week 24 of the study (P = .003). There was a significantly higher proportion of treated IHs that reduced in size by .5% at weeks 20 and 24 (P , .02). The predicted proportion of IH volume change was also significantly less for treated IHs from week 16 onward when compared with placebo (P , .05). There was no significant variation in blood pressure and heart rate between the groups. CONCLUSIONS: Topical timolol maleate 0.5% gel with a maximum dose of 0.5 mg per day is a safe and effective option for small superficial IHs that have not ulcerated and are not on mucosal surfaces. Pediatrics

show abstract

How to Measure a Growing Hemangioma and Assess Response to Therapy

Cited by 26 publications

References 2 publications

3D photography is a reliable method of measuring infantile haemangioma volume over time

3D photography is a reliable method of measuring infantile haemangioma volume over time

Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma

RCT of Timolol Maleate Gel for Superficial Infantile Hemangiomas in 5- to 24-Week-Olds

Contact Info

Product

Resources

About