How to interpret skin prick tests and serum-specific IgE in children and young people with food allergy

Ferris, Kathryn; Cowan, Marianne; Williams, Christine M.; McAteer, Sinead; Glancy, Caoimhe; Callaghan, Sheila

doi:10.1136/archdischild-2020-320562

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…This response is compared with a negative control (eg, saline) and a positive control (eg, histamine). 2 4 How to perform an SPT and interpret the results was recently described by Ferris et al 10…”

Section: Importance Of Medical Historymentioning

confidence: 99%

How to diagnose IgE-mediated food allergy

Lieberman,

Muraro,

Blaiss

2024

Arch Dis Child Educ Pract Ed

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Immunoglobulin E (IgE)-mediated food allergy is an immune response, typically to a food protein. Accurate diagnosis reduces unnecessary dietary restrictions and economic and psychological burden on patients and caregivers but relies on a rigorous clinical history, specific IgE diagnostic tests and, where needed, oral food challenge. Increased awareness is needed around which patients to test for IgE-mediated food allergy, as well as terms commonly associated with IgE-mediated food allergy testing, in order to optimise patient diagnosis and management. Herein, we describe approaches to diagnosis of IgE-mediated food allergy, appropriate interpretation of results and risks of overtesting.

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Section: Importance Of Medical Historymentioning

confidence: 99%

How to diagnose IgE-mediated food allergy

Lieberman,

Muraro,

Blaiss

2024

Arch Dis Child Educ Pract Ed

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“…When an allergen injected to the epidermis of the skin, sIgE bound to mast cells will cross-link resulting in mast cell degranulation and histamine release. This histamine produces urticarial responses and flares [29].…”

Section: Skin Prick Test (Spt)mentioning

confidence: 99%

The link between food allergy and atopic dermatitis

Dhany Prafita Ekasari,

Dixy Febrianita TPP

2023

World J. Adv. Res. Rev.

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Food allergy (FA) is an abnormal or exaggerated specific immune response that occurs repeatedly when exposed to certain foods. The relationship between food allergies and AD is still much debated today. Some evidence supports that AD can play a role as a predisposing factor for food allergies and conversely, food allergens are also suspected as one of the triggers of AD exacerbations. Role of diet in the cause and treatment of AD is controversial and is not well-defined. Food elimination diets in food allergic cases may have a beneficial effect on AD morbidity, however prolonged diets can lead to loss of tolerance and potentially increase the risk of IgE-mediated food allergy. Emollient treatment, hidrolized formulas, vitamin D, early introduction of food allergens appears to be a promising strategy for minimizing the public health burden of food allergy in AD, though further studies of this approach is needed.

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Positive rate of wheat allergens in the Chinese allergic population: a systematic review and meta-analysis

Yang

Zhao

Liu

et al. 2023

Sci Rep

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In recent years, the prevalence of allergic diseases has increased significantly, causing great concern, and wheat, as one of the top 8 food allergens, is a common allergy trigger. Nevertheless, reliable estimates of the positivity rate of wheat allergens in the allergic population in China are still lacking. The systematic review and meta-analysis aims to evaluate the positive detection rate of wheat allergens in the Chinese allergic population and further provide a reference for the prevention of allergy. CNKI, CQVIP, WAN-FANG DATA, Sino Med, PubMed, Web of Science, Cochrane Library, and Embase databases were retrieved. Related research and case reports about the positive rate of wheat allergen in the Chinese allergic population published from inception to June 30, 2022, were searched, and meta-analysis was performed using Stata software. The pooled positive rate of wheat allergens and 95% confidence interval were calculated by random effect models, and the publication bias was evaluated using Egger’s test. A total of 13 articles were included for the final meta-analysis, in which wheat allergen detection methods involved only serum sIgE testing and SPT assessment. The results showed that the wheat allergen positivity detection rate in Chinese allergic patients was 7.30% (95% CI 5.68–8.92%). Subgroup analysis showed that the positivity rate of wheat allergens was influenced by region, but hardly by age and assessment method. The positive rates of wheat allergy in the population with allergic diseases were 2.74% (95% CI 0.90–4.58%) and 11.47% (95% CI 7.08–15.87%) in southern and northern China, respectively. In particular, the positive rates of wheat allergens were greater than 10% in Shaanxi, Henan and Nei Mongol, all of which belong to the northern region. These results suggest that wheat allergens are an important cause of sensitization in allergic populations from northern China, and therefore attention should be paid to early prevention in high-risk populations.

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How to interpret skin prick tests and serum-specific IgE in children and young people with food allergy

Cited by 4 publications

References 18 publications

How to diagnose IgE-mediated food allergy

How to diagnose IgE-mediated food allergy

The link between food allergy and atopic dermatitis

Positive rate of wheat allergens in the Chinese allergic population: a systematic review and meta-analysis

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