How to Improve SBRT Outcomes in NSCLC: From Pre-Clinical Modeling to Successful Clinical Translation

Abstract

Despite major research and clinical efforts, lung cancer remains the leading cause of cancer-related death. While the delivery of conformal radiotherapy and image guidance of stereotactic body radiotherapy (SBRT) have revolutionized the treatment of early-stage non-small-cell lung cancer (NSCLC), additional research is needed to elucidate underlying mechanisms of resistance and identify novel therapeutic combinations. Clinical progress relies on the successful translation of pre-clinical work, which so far has not always yielded expected results. Improved clinical modelling involves characterizing the preclinical models and selecting appropriate experimental designs that faithfully mimic precise clinical scenarios. Here, we review the current role of SBRT and the scope of pre-clinical armamentarium at our disposal to improve successful clinical translation of pre-clinical research in the radiation oncology of NSCLC.

Effect of stereotactic radiotherapy on immune microenvironment of lung cancer

“…Although there are increasing preclinical and clinical data on the combination of radiotherapy and immunomodulators, and the application prospect is exciting, most of the available data are currently from retrospective or small cohorts. Many problems related to the use of SRT to improve clinical conversion to immunotherapy efficacy remain unsolved, such as dose fractionation, treatment sequence, selection of immunomodulators, and biomarkers predicting treatment response (42). In particular, there are few studies about the immune microenvironment of SRT in some special sites of metastases.…”

Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase activities

“…Indeed, intriguing results have came from a number of treatment studies employing animal models. But none of the pre-clinical phases were practical or useful in extensive human clinical practice ( Milic et al, 2022 ). It was decided to use Ginkgo biloba L. in this case because of its unique properties of antioxidative and anti-inflammatory properties.…”

Genome-wide analyses of lung cancer after single high-dose radiation at five time points (2, 6, 12, 24, and 48 h)

“…In recent years, precision radiotherapy applied high-dose therapy (Burkoň et al, 2022;Chairmadurai et al, 2022;DLP et al, 2022;Milic et al, 2022;Sidaway, 2022;Tadimalla et al, 2022). Stereotactic body radiotherapy (SBRT) has the characteristics of high tumor dose distribution in the irradiation center and a rapid drop of extradural dose.…”