How to face the aging world – lessons from dementia research

Mitrečić, Dinko; Petrović, Dražen Juraj; Stančin, Paula; Isakovic, Jasmina; Zavan, Barbara; Tricarico, Gerardo; Tiljak, Mirjana Kujundžić; Luca, Mónica Di

doi:10.3325/cmj.2020.61.139

Cited by 5 publications

(7 citation statements)

References 51 publications

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Section: The Current Arsenal Of Biomarkersmentioning

confidence: 99%

“…The stakeholder community fails to come together to enhance understanding of AD generally, as well as current and possible future treatment options, or to develop plans that will secure continuous progress in basic science and bring innovations to markets. There is growing interest in creating academic-industry partnerships in areas that could lead to the co-development of drugs and biomarkers [26].…”

Section: Hurdlesmentioning

confidence: 99%

“…One approach is the transformation of hair follicles into neurons, which can then be used either for early diagnostics or for discovering new pathophysiological elements of AD. Similar application of stem cells for early diagnostics is present in the “Check My Brain” diagnostic and therapeutic platform [26]. It offers a simple procedure which provides three sets of information: (1) early diagnostics of brain diseases, by detecting biomarkers using cell cultures, (2) the prognosis of disease progression by assessing the changes in biomarker levels, and (3) personalised instructions on dietary, supplementary, and other approaches that could bring benefit for the individual brain cells.…”

Section: The Current Arsenal Of Biomarkersmentioning

confidence: 99%

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Biomarker Testing: Piercing the Fog of Alzheimer’s and Related Dementia

Horgan¹,

Nobili

Teunissen

et al. 2020

Biomed Hub

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Alzheimer’s disease (AD) and related dementia is one of the growing threats to the sustainability of health and care systems in developed countries, and efforts to find therapies have had scant success. The main reasons for this are lack of efficient therapy, which is linked to too late discovery of the disease itself. With this in mind, biomarkers are recognised as an element which can bring a major contribution to research, helping elucidate the disease and the search for treatments. They are also playing an increasing role in early detection and timely diagnosis, which are considered the principal hopes of effective management in the absence of an effective drug. The current arsenal of biomarkers could already, if more widely deployed, provide an effective minimum service to patients and health systems. A concerted action by policy makers and stakeholders could drive progress in access to AD biomarker testing to provide an optimum service in the medium term. AD and related dementia is one of the growing threats to the sustainability of health and care systems in developed countries, and efforts to find therapies have had scant success. The main reasons for this are lack of efficient therapy, which is linked to too late discovery of the disease itself. With this in mind, biomarkers are recognised as an element which can bring a major contribution to research, helping elucidate the disease and the search for treatments. They are also playing an increasing role in early detection and timely diagnosis, which are considered the principal hopes of effective management in the absence of an effective drug. The current arsenal of biomarkers could already, if more widely deployed, provide an effective minimum service to patients and health systems. A concerted action by policy makers and stakeholders could drive progress in access to AD biomarker testing to provide an optimum service in the medium term.

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Section: The Current Arsenal Of Biomarkersmentioning

confidence: 99%

Section: Hurdlesmentioning

confidence: 99%

Section: The Current Arsenal Of Biomarkersmentioning

confidence: 99%

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Biomarker Testing: Piercing the Fog of Alzheimer’s and Related Dementia

Horgan¹,

Nobili

Teunissen

et al. 2020

Biomed Hub

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“…The first factor accounted for 31% of variance (eigen = 6.94), included 9 items ( 2 , 3 , 8 , 10 - 12 , 17 , 18 , 22 ) with Cronbach α of 0.88, and may be interpreted as personal strain. The second factor accounted for 10% of variance (eigen = 2.06), included 6 items ( 3 , 5 , 6 , 9 , 16 , 18 ) with Cronbach α of 0.83, and may be interpreted as frustration. The third factor accounted for 9% of variance (eigen = 1.94), included 5 items ( 1 , 4 , 6 , 13 , 14 ) with Cronbach α of 0.72, and may be interpreted as embarrassment.…”

Section: Resultsmentioning

confidence: 99%

“…Dementia is an increasing health care problem associated with population aging ( 1 - 3 ). There are 8.9 million persons worldwide caring for patients with dementia older than 50 years ( 4 ).…”

mentioning

confidence: 99%

A validation of the Croatian version of Zarit Burden Interview and clinical predictors of caregiver burden in informal caregivers of patients with dementia: a cross-sectional study

Lucijanic¹,

Baždarić²,

Librenjak³

et al. 2020

Croat Med J

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Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p

Stančin

Song²,

Alajbeg

et al. 2022

Cell Mol Neurobiol

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The success rate of regenerative medicine largely depends on the type of stem cells applied in such procedures. Consequently, to achieve the needed level for clinical standardization, we need to investigate the viability of accessible sources with sufficient quantity of cells. Since the oral region partly originates from the neural crest, which naturally develops in niche with decreased levels of oxygen, the main goal of this work was to test if human oral mucosa stem cells (hOMSC) might be used to treat neurons damaged by anoxia. Here we show that hOMSC are more resistant to anoxia than human induced pluripotent stem cells and that they secrete BDNF, GDNF, VEGF and NGF. When hOMSC were added to human neurons damaged by anoxia, they significantly improved their survival. This regenerative capability was at least partly achieved through miR-514A-3p and SHP-2 and it decreased in hOMSC exposed to neural cells for 14 or 28 days. In addition, the beneficial effect of hOMSC were also confirmed in mice affected by stroke. Hence, in this work we have confirmed that hOMSC, in a time-limited manner, improve the survival of anoxia-damaged neurons and significantly contribute to the recovery of experimental animals following stroke.

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How to face the aging world – lessons from dementia research

Cited by 5 publications

References 51 publications

Biomarker Testing: Piercing the Fog of Alzheimer’s and Related Dementia

Biomarker Testing: Piercing the Fog of Alzheimer’s and Related Dementia

A validation of the Croatian version of Zarit Burden Interview and clinical predictors of caregiver burden in informal caregivers of patients with dementia: a cross-sectional study

Human Oral Mucosa Stem Cells Increase Survival of Neurons Affected by In Vitro Anoxia and Improve Recovery of Mice Affected by Stroke Through Time-limited Secretion of miR-514A-3p

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