How to diagnose and follow patients with glomerulonephritis without kidney biopsy?

Mucha, Krzysztof; Foroncewicz, Bartosz; Pączek, Leszek

doi:10.20452/pamw.3510

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…The main causes of CKD are: diabetes mellitus, hypertension, glomerulonephritis and cardiovascular diseases (Fig. 1 d) (Mucha et al 2016 ; Vassalotti et al 2010 ). CKD is frequently progressive and the progression depends on both the primary disease as well as other factors, such as diet, smoking, coexisting obesity, etc.…”

Section: Introductionmentioning

confidence: 99%

“…The initial suspicion of CKD is based on the clinical symptoms, such as proteinuria, erythrocyturia or hematuria, edema or hypertension. However, the final diagnosis must be confirmed by kidney biopsy (Mucha et al 2016 ), which is an invasive diagnostic method—for that reason the researchers and nephrologists are looking for a safer and less-invasive diagnostic methods (Mucha et al 2014 ). The researchers discovered numerous serum or urine components, that can contribute to the pathogenesis of kidney diseases and therefore, might be taken under consideration as potential biomarkers.…”

Section: Introductionmentioning

confidence: 99%

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Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Krata

Zagożdżon

Foroncewicz

et al. 2017

Arch. Immunol. Ther. Exp.

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Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism’s cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease. The course of CKD depends on the primary disease. It is assumed that one of the factors influencing the course of CKD might be OS. In the current work, we review whether monitoring the OS-associated biomarkers in nephrology patients can support the decision-making process regarding diagnosis, prognostication and treatment initiation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Krata

Zagożdżon

Foroncewicz

et al. 2017

Arch. Immunol. Ther. Exp.

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“…Unfortunately, the "cocktail" of antibodies used in the currently available immunoassays does not distinguish between various molecular forms of NGAL and does not allow the unambiguous determination of the protein source. Moreover, in the biological material from patients with different pathological conditions there may be present various substances interfering in immunoassays (matrix effect) [7,10].…”

Section: Discussionmentioning

confidence: 99%

“…Metabolomics research through the analysis of circulating metabolites of renal gluconeogenesis strengthens the hypothesis about the involvement of the proximal tubule in the pathology of SRNS. Very recent data suggest that proteomic analysis is capable of identifying candidate biomarkers of steroid resistance in paediatric nephrotic syndrome [7]. Further research is required to identify diagnostic markers using modern analytical techniques such as liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS) [20].…”

Section: Discussionmentioning

confidence: 99%

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Response to corticosteroid therapy is not related to serum and urine NGAL concentration in nephrotic children

Ochocińska¹,

Jarmużek²,

Janas³

et al. 2018

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Aim of the study: Response to corticosteroids is a major factor determining the final outcome of nephrotic syndrome (NS) in children. There is no consensus in terms of specific biomarkers of steroid sensitivity. There are reports on the value of urine neutrophil gelatinase-associated lipocalin (uNGAL) as a marker of steroid sensitivity, although this has not been definitively established. Objectives: To evaluate serum (s) and urine (u) NGAL concentrations as markers of response to steroid therapy. Material and methods: This was a retrospective study including 43 patients (1-17 years old) divided into two groups as follows: 1) children with steroid-resistant nephrotic syndrome (SRNS, n = 14) treated with additional immunosuppressive drugs, including cyclosporine A (CsA) and/or mycophenolate mofetil (MMF); and 2) steroid-sensitive nephrotic syndrome (SSNS, n = 29). The control group consisted of age-matched healthy children (HC, n = 59). Results: Median sNGAL concentration was higher in nephrotic patients (83.0, 43.8-351 ng/ml) compared to HC (51.4, 12.1-193 ng/ml; p = 0.00). There was no difference in the sNGAL level between SRNS and SSNS patients (p = 0.34). Median uNGAL level was higher in the SRNS patients, compared to that in the SSNS group, although the difference was not significant (2.71 ng/ml, range: 0.02-62.8 ng/ml and 1.17 ng/ml, range: 0.02-99.3 ng/ml, respectively; p = 0.26). Median sNGAL was higher in children treated with triple-drug regimens including cyclosporine A (CsA) (82.6, 68.6-351 ng/ml) compared to the patients on double-drug regimen including mycophenolate mofetil (MMF) (p = 0.03). There was no correlation between sNGAL and CsA dose/blood concentration ratio. We found a negative correlation between sNGAL and renal function, reflected by the eGFR (r = -0.41, p = 0.01). Conclusions: sNGAL concentration did not differ between steroid-resistant and steroid-sensitive nephrotic syndrome patients. The higher sNGAL concentration in patients on triple therapy (cyclosporine A + mycophenolate mofetil + prednisone -CsA + MMF + PRED) reflects inferior renal function in patients with the most severe clinical course of NS.

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Peroxiredoxins as Markers of Oxidative Stress in IgA Nephropathy, Membranous Nephropathy and Lupus Nephritis

Krata

Foroncewicz

Zagożdżon

et al. 2021

Arch. Immunol. Ther. Exp.

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IgA nephropathy (IgAN), membranous nephropathy (MN), and lupus nephritis (LN) represent important causes of chronic kidney disease. They belong to the immune-mediated glomerulonephritis (GNs), and have distinct pathogenesis, distinct clinical courses, and variable responses to treatment. Therefore, specific diagnostic procedures are necessary for more effective patient management. Recently, a role for oxidative stress has been proposed in various renal disorders. Thus, molecules related to oxidative stress, such as 2-Cys-peroxiredoxins (PRDXs), may represent plausible candidates for biomarkers in renal pathologies. The aim of this study was to assess whether there are differences between individual GNs and healthy controls in the context of PRDXs serum concentration. We enrolled 108 patients with biopsy-proven IgAN (47), MN (26), LN (35) and 30 healthy age- and sex-matched controls. The serum concentrations of PRDX 1–5 were measured with ELISA assays and correlated with demographic and clinical data. The PRDXs’ concentration varied depending on the GN type. We also observed an association of PRDXs with lower estimated glomerular filtration rates, complement, hemoglobin, and body mass index. Our study indicates that individual PRDX can play roles in pathophysiology of selected GNs and that their serum concentrations may become useful as a new supplementary diagnostic markers in IgAN, MN as well as LN. The results of this study open a new avenue for prospective research on PRDXs in renal diseases.

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How to diagnose and follow patients with glomerulonephritis without kidney biopsy?

Cited by 4 publications

References 9 publications

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Response to corticosteroid therapy is not related to serum and urine NGAL concentration in nephrotic children

Peroxiredoxins as Markers of Oxidative Stress in IgA Nephropathy, Membranous Nephropathy and Lupus Nephritis

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