How to determine whether conceptual endophenotypes can improve clinical outcomes in patients suffering from major depression: An exploratory approach

Bergemann, Niels; Bruhn, Karl T; Loscheider, K.; Vogt, Dominic; Böhnke, Jan R.; Gerhards, Friedemann

doi:10.1016/j.psyneuen.2019.03.010

Cited by 1 publication

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References 46 publications

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“…Neuropattern, a new concept used in diagnosis based on the idea of endophenotypes, was then proposed. One exploratory study showed its potential in showing a greater reduction in symptomatic severity and faster response to treatment in the Neuropattern group compared to standard care ( 11 ). Such approaches are based on the genetic variations underlying differences in brain circuitry which can explain the differences in affective, cognitive, and behavioral symptoms.…”

Section: Current State Of the Artmentioning

confidence: 99%

Depression From a Precision Mental Health Perspective: Utilizing Personalized Conceptualizations to Guide Personalized Treatments

Deif

Salama

2021

Front. Psychiatry

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Modern research has proven that the “typical patient” requiring standardized treatments does not exist, reflecting the need for more personalized approaches for managing individual clinical profiles rather than broad diagnoses. In this regard, precision psychiatry has emerged focusing on enhancing prevention, diagnosis, and treatment of psychiatric disorders through identifying clinical subgroups, suggesting personalized evidence-based interventions, assessing the effectiveness of different interventions, and identifying risk and protective factors for remission, relapse, and vulnerability. Literature shows that recent advances in the field of precision psychiatry are rapidly becoming more data-driven reflecting both the significance and the continuous need for translational research in mental health. Different etiologies underlying depression have been theorized and some factors have been identified including neural circuitry, biotypes, biopsychosocial markers, genetics, and metabolomics which have shown to explain individual differences in pathology and response to treatment. Although the precision approach may prove to enhance diagnosis and treatment decisions, major challenges are hindering its clinical translation. These include the clinical diversity of psychiatric disorders, the technical complexity and costs of multiomics data, and the need for specialized training in precision health for healthcare staff, besides ethical concerns such as protecting the privacy and security of patients' data and maintaining health equity. The aim of this review is to provide an overview of recent findings in the conceptualization and treatment of depression from a precision mental health perspective and to discuss potential challenges and future directions in the application of precision psychiatry for the treatment of depression.

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Section: Current State Of the Artmentioning

confidence: 99%