How to design magneto-based total analysis systems for biomedical applications

Weddemann, Alexander; Albon, Camelia; Auge, Alexander; Wittbracht, Frank; Hedwig, Peter; Akemeier, Dieter; Rott, Karsten; Meißner, Daniel; Jutzi, Peter; Hütten, Andreas

doi:10.1016/j.bios.2010.06.031

Cited by 32 publications

(23 citation statements)

References 35 publications

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“…Magnetic micro-and nano-structures with unique shapes other than the conventional sphere can be controlled with an external magnetic field. Weddemann et al (2010) reviewed the implementation of magnetic components in total analysis systems for biomedical applications. The scope of this review was limited to the detection and manipulation of magnetic beads.…”

Section: Introductionmentioning

confidence: 99%

Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Nguyen

2011

Microfluid Nanofluid

336

169

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Micro-magnetofluidics refers to the science and technology that combines magnetism with microfluidics to gain new functionalities. Magnetism has been used for actuation, manipulation and detection in microfluidics. In turn, microfluidic phenomena can be used for making tunable magnetic devices. This paper presents a systematic review on the interactions between magnetism and fluid flow on the microscale. The review rather focuses on physical and engineering aspects of micro-magnetofluidics, than on the biological applications which have been addressed in a number of previous excellent reviews. The field of micromagnetofluidics can be categorized according to the type of the working fluids and the associated microscale phenomena of established research fields such as magnetohydrodynamics, ferrohydrodynamics, magnetorheology and magnetophoresis. Furthermore, similar to microfluidics the field can also be categorized as continuous and digital micro-magnetofluidics. Starting with the analysis of possible magnetic forces in microscale and the impact of miniaturization on these forces, the paper revisits the use of magnetism for controlling fluidic functions such as pumping, mixing, magnetowetting as well as magnetic manipulation of particles. Based on the observations made with the state of the art of the field micro-magnetofluidics, the paper presents some perspectives on the possible future development of this field. While the use of magnetism in microfluidics is relatively established, possible new phenomena and applications can be explored by utilizing flow of magnetic and electrically conducting fluids.

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Section: Introductionmentioning

confidence: 99%

Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Nguyen

2011

Microfluid Nanofluid

336

169

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“…In fact, stretchabilities of a few percent only 145,166 can be achieved in this way, unless cracking of the sensing layer is permitted, which can result in higher stretchabilities 167 . However, stretching due to crack formation is applicable only for thin film elements that are much larger than the cracks and hence, this approach contradicts the device miniaturization, which is highly relevant especially for the integration into wearable navigation and orientation systems, bio-medical systems 188,189 or for the fine mapping of inhomogeneous magnetic fields and textures. Other applications fields like smart skins 44,53 , functional medical implants 47,67 and soft robotics 69,74 , require stretchabilities of electronic components in the order of 20% or more for useful integration.…”

Section: Direct Transfer Printing Of Gmr Sensoricsmentioning

confidence: 99%

“…However, different applications demand different sensing capabilities that require specific features of the sensor response, like a linear characteristic or a high sensitivity to low magnetic field strengths. One example is the application of magnetic sensors is medical diagnostics or bio-analytic systems [187][188][189][190] , which demands the reliable detection of magnetic field in the range of 10 Oe and below.…”

Section: Demonstrator: Magnetic Detection On a Curved Surfacementioning

confidence: 99%

Stretchable Magnetoelectronics

et al. 2011

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Abstract:In this work, stretchable magnetic sensorics is successfully established by combining metallic thin films revealing a giant magnetoresistance effect with elastomeric materials. Stretchability of the magnetic nanomembranes is achieved by specific morphologic features (e.g. wrinkles), which accommodate the applied tensile deformation while maintaining the electrical and magnetic integrity of the sensor device. The entire development, from the demonstration of the world-wide first elastically stretchable magnetic sensor to the realization of a technology platform for robust, ready-touse elastic magnetoelectronics with fully strain invariant properties, is described. The prepared soft giant magnetoresistive devices exhibit the same sensing performance as on conventional rigid supports, but can be stretched uniaxially or biaxially reaching strains of up to 270% and endure over 1,000 stretching cycles without fatigue. The comprehensive magnetoelectrical characterization upon tensile deformation is correlated with in-depth structural investigations of the sensor morphology transitions during stretching.With their unique mechanical properties, the elastic magnetoresistive sensor elements readily conform to ubiquitous objects of arbitrary shapes including the human skin. This feature leads electronic skin systems beyond imitating the characteristics of its natural archetype and extends their cognition to static and dynamic magnetic fields that by no means can be perceived by human beings naturally.Various application fields of stretchable magnetoelectronics are proposed and realized throughout this work. The developed sensor platform can equip soft electronic systems with navigation, orientation, motion tracking and touchless control capabilities. A variety of novel technologies, like smart textiles, soft robotics and actuators, active medical implants and soft consumer electronics will benefit from these new magnetic functionalities. Michael Melzer: Stretchable MagnetoelectronicsOutline 4

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“…To sum up, remarkable progress has been made in the application of MNPs to single-molecule detection, disease diagnosis as well as pathogen detection. In biosensing devices, MNPs can be assembled onto the sensor surface or used as labels (Weddemann et al, 2010;Chen Y. et al, 2018). In addition to the structure and composition of MNPs, the selection of surface functional groups and target molecules is also crucial to the expansion of MNPs to a variety of biosensor applications (Chen et al, 2017;Avval et al, 2019).…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Application of Zero-Dimensional Nanomaterials in Biosensing

et al. 2020

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Zero-dimensional (0D) nanomaterials, including graphene quantum dots (GQDs), carbon quantum dots (CQDs), fullerenes, inorganic quantum dots (QDs), magnetic nanoparticles (MNPs), noble metal nanoparticles, upconversion nanoparticles (UCNPs) and polymer dots (Pdots), have attracted extensive research interest in the field of biosensing in recent years. Benefiting from the ultra-small size, quantum confinement effect, excellent physical and chemical properties and good biocompatibility, 0D nanomaterials have shown great potential in ion detection, biomolecular recognition, disease diagnosis and pathogen detection. Here we first introduce the structures and properties of different 0D nanomaterials. On this basis, recent progress and application examples of 0D nanomaterials in the field of biosensing are discussed. In the last part, we summarize the research status of 0D nanomaterials in the field of biosensing and anticipate the development prospects and future challenges in this field.

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How to design magneto-based total analysis systems for biomedical applications

Cited by 32 publications

References 35 publications

Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Micro-magnetofluidics: interactions between magnetism and fluid flow on the microscale

Stretchable Magnetoelectronics

Application of Zero-Dimensional Nanomaterials in Biosensing

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