How to Deal With Vaccine Breakthrough Infection With SARS-CoV-2 Variants

Guo, Ying; Meng, Jian; Liu, Caide; Chen, Guosheng; Chi, Yuhua; Zheng, Shiliang; Wang, Haixia

doi:10.3389/fpubh.2022.842303

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…Accelerated vaccine development is also fraught with ethical questions, especially with the hyperreduced time spent on phases II and III of clinical trials. In a study, it is recommended for vaccine breakthrough infection that; firstly, the use of the vaccine should be spread as soon as possible and further optimized and its quality should be enhanced [132]. However in the practice, new complications arise in vaccinated individuals after a certain time, as many serious ones started to be reported, through rare but which shouldn't be ignored.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccine-related pathologies: cardiac and neurological side effects and Long-term COVID-19

ANILANMERT,

YONAR,

RAYIMOGLU

2023

jrp

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Soon after the commencement of the mass immunization programs, the safety of the COVID-19 vaccines became a top issue. An increase is noticed in the literature in complaints and complications among the public due to a variety of adverse reactions, ranging from the most minor ones like fever, local pain, and myalgias to several potentially serious cardiac and neurological complications like blood clotting, Bell's palsy, myocarditis, hypertensive crisis, pericarditis, and other serious cardiovascular events. Transverse myelitis, cerebral venous thrombosis, and acute inflammatory demyelinating polyneuropathy were only a few among many more conditions. Most of COVID-19 vaccines function through expressing spike protein. They accomplish this either by transfecting the cells with a spike mRNA or by infecting them with an adenovirus containing a spike gene. When spike is expressed, the immune system recognizes it as a foreign antigen and mounts an attack on the protein and consequently on SARS-CoV-2 in case of any contagion. However, the spike protein is the virus's primary mechanism for infection and is accountable for the majority of the complications that COVID 19 brought. When it exists or is produced in sufficient quantities in the body, it can mimic partially a COVID-19 pathological picture, including a cytokine storm, particularly following vaccinations of infected people. In order to know the long-term safety of any new COVID-19 vaccine as any new type of pharmaceutical product, clinical data should be continuously collected for long-term adverse reactions using the country's effective pharmacovigilance systems and questioning the vaccination effect during the diagnosis in hospitals.

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Section: Discussionmentioning

confidence: 99%

COVID-19 vaccine-related pathologies: cardiac and neurological side effects and Long-term COVID-19

ANILANMERT,

YONAR,

RAYIMOGLU

2023

jrp

View full text Add to dashboard Cite

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“…The pandemic situation in Indonesia was officially announced in March 2020 and has been bagging 3.930.300 cases since then, ranking the country as one with the highest cases in Southeast Asia and fourth in Asia [1]. Furthermore, this situation is worsened by the recent Delta variant (B.1.617.2) outbreak which originated from India and is 60% more transmissible than the Alpha variant [2] in addition to its higher immunity evasion and vaccine resistance [3], this variant outbreak made the daily case in Indonesia skyrocketed to more than 50000 cases on July 21 st [1].…”

Section: Introductionmentioning

confidence: 99%

Developing Touchless Dispenser System Based on IoT to Support Hydration Needs for University Students in New Normal Phase in Indonesia

Ahnaf¹,

Atmaja²,

Rachmat³

et al. 2023

Int. J. Adv. Sci. Eng. Inf. Technol.

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Following the global pandemic of COVID-19, in August 2021, Indonesia achieved a total of 3.930.300 cases, the highest in Southeast Asia. However, the government is keen on promoting the new normal phase and planning to open schools and permit faceto-face learning, from elementary up to universities. This means that public facilities and infrastructures will be used and can be the medium for virus transmission, as it will require 48 to 72 hours for the virus to be inactive on those surfaces. This will make people reluctant to touch surfaces, especially when it comes to public facilities that can provide for their needs. One of the most important is the need for hydration which is often overlooked. About 25% of college students were found dehydrated, and 37,5% showed signs of it. Dehydration could prove a serious threat to health had it been overlooked and could affect physical and cognitive performance, having more effects on students and lectures, requiring both in their activities. To support the needs of hydration amidst the pandemic, this research developed a touchless water dispenser system using the waterfall model, utilizing a cloud database with ESP32, controlled by users through an android application. The design is easy and cheap to install, even on regular dispensers, making it an effective and efficient alternative public facility providing hydration service to support the new normal phase.

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Serological Response and Clinical Protection of Anti-SARS-CoV-2 Vaccination and the Role of Immunosuppressive Drugs in a Cohort of Kidney Transplant Patients

Pinchera

Carrano

Moriello

et al. 2022

Viruses

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Vaccination against SARS-CoV2 represents a key weapon to prevent COVID-19, but lower response rates to vaccination have frequently been reported in solid organ transplant recipients. The aim of our study was to evaluate the rate of seroconversion to SARS-CoV-2 mRNA vaccines in a cohort of kidney transplant recipients and the potential role of the different immunosuppressive regimens. We conducted an observational retrospective cohort study in kidney transplant patients vaccinated for COVID-19. For each patient, we evaluated IgG anti-S-RBD SARS-CoV-2 titers immediately before the administration of first COVID-19 vaccination dose, 20 days after the first dose and 40 days after the second dose. Moreover, we evaluated the type of immunosuppressive treatment and the incidence of vaccine breakthrough SARS-CoV-2 infection. We enrolled 121 kidney transplant patients vaccinated for COVID-19. At the time of administration of the first vaccine dose, all patients had a negative antibody titer; only 4.1% had positive antibody titers 20 days after the first dose. More than half patients 62 (51%) had protective antibody titers 40 days after the second dose. A total of 18 Solid Organ Transplant Recipients (SOTRs) (14.9%) got a SARS-CoV-2 breakthrough infection during the study period. With regard to immunosuppressive regimen, patients on mycophenolate-based regimen (48.7%) showed the lowest antibody response rates (27.5%) compared to other regimens. Our study confirms that kidney transplant patients show a poor response to two doses of COVID-19 vaccination. Moreover, in our study the use of mycophenolate is significantly associated with a non-response to COVID-19 m-RNA vaccines.

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How to Deal With Vaccine Breakthrough Infection With SARS-CoV-2 Variants

Cited by 3 publications

References 62 publications

COVID-19 vaccine-related pathologies: cardiac and neurological side effects and Long-term COVID-19

COVID-19 vaccine-related pathologies: cardiac and neurological side effects and Long-term COVID-19

Developing Touchless Dispenser System Based on IoT to Support Hydration Needs for University Students in New Normal Phase in Indonesia

Serological Response and Clinical Protection of Anti-SARS-CoV-2 Vaccination and the Role of Immunosuppressive Drugs in a Cohort of Kidney Transplant Patients

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