How to deal with subcentimeter lung cancer: a moving target!

Schil, Paul Van

doi:10.21037/jtd.2016.09.53

Cited by 2 publications

(1 citation statement)

References 29 publications

(26 reference statements)

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“…Subcentimeter lung cancers, currently T1a disease, represent a specific subgroup, as they comprise the smallest lesions 23 . For this reason, they have become a specific focus of interest.…”

Section: Limited Resection Of Early Stage Lung Cancermentioning

confidence: 99%

Non-small cell lung cancer: the new T1 categories

Schil

2017

F1000Res

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Recently, major changes have occurred in the staging, diagnosis, and treatment of early stage lung cancer. By screening high-risk populations, we are now able to detect lung cancers at an early stage, but the false-positive rate is high. A new pathological classification was published in 2011 and fully incorporated in the 2015 World Health Organisation (WHO) Classification of Tumours of the Lung, Pleura, Thymus, and Heart. The new eighth edition of the tumour–node–metastasis (TNM) staging system has been fully published and will be in use from January 2017. T1 lesions are subdivided into T1a, T1b, and T1c lesions corresponding to lung cancers up to 10 mm, between 11 and 20 mm, and between 21 and 30 mm, respectively. To determine the size, only the solid part on computed tomographic scanning of the chest and the invasive part on pathological examination will be considered. Prognosis is significantly better for the smallest lesions. For some specific subgroups, sublobar resection may be oncologically valid and yield good long-term outcome, but the results of recently performed randomised trials are awaited.

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Section: Limited Resection Of Early Stage Lung Cancermentioning

confidence: 99%

Non-small cell lung cancer: the new T1 categories

Schil

2017

F1000Res

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Outcome of Resected Lung Cancers with Subcentimeter Solid Component on Computed Tomography

Kawaguchi

Yoshikawa

Nakai

et al. 2022

Thorac Cardiovasc Surg

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Background Although the opportunity to treat subcentimeter lung cancers has increased, the optimal surgical methods remain unclear. We performed a retrospective study to examine the clinical outcome of subcentimeter lung cancers. Patients and Methods In total, 118 patients who underwent curative resection for subcentimeter lung cancer from January 2005 to December 2013 were analyzed. Multivariate Cox proportional hazards models were used to calculate the hazard ratio to identify independent predictors of recurrence-free survival (RFS) and overall survival (OS). Results Anatomical resections were performed for 64 patients (59 lobectomies and 5 segmentectomies) and wedge resections for 54 patients. Recurrence developed in six patients who had consolidation-predominant tumors (consolidation/tumor [C/T] ratio of >0.5) and underwent wedge resections. The first recurrence patterns were regional recurrences in three patients, both regional and distant in one, and distant in two. Seventeen patients died of other causes. The multivariate analysis revealed that the C/T ratio was the independent predictor of RFS (p = 0.008) and OS (p = 0.011). Conclusion Patients with subcentimeter lung cancer rarely developed recurrence. The C/T ratio was the independent prognostic factor, and all relapsed patients received wedge resections. Even for subcentimeter lung cancers, we should select the extent of pulmonary resection after thoroughly considering whether wedge resection (less invasiveness) is a reasonable alternative to anatomical resection (superior oncologic efficacy) considering the C/T ratio of the lesion.

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How to deal with subcentimeter lung cancer: a moving target!

Cited by 2 publications

References 29 publications

Non-small cell lung cancer: the new T1 categories

Non-small cell lung cancer: the new T1 categories

Outcome of Resected Lung Cancers with Subcentimeter Solid Component on Computed Tomography

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