How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease

Capocasale, Giorgia; Nocini, Riccardo; Faccioni, P; Donadello, D; Bertossi, Dario; Aglietta, Massimo; Zotti, Francesca

doi:10.1002/cre2.332

Cited by 28 publications

(43 citation statements)

References 49 publications

(80 reference statements)

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“…An important advantage of using radiological examination, to the detriment of oral examination, is dependent on the current epidemiological context. The COVID-19 pandemic has led to a decline in dental services provided for pediatric patients [ 25 ] with oral examinations performed on large samples being difficult due to strict infection control measures [ 26 ]. At the same time, periapical radiographs and bite-wing radiographs were avoided in line with the policies and recommendations issued by the competent authorities in Romania.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Age on the Development of Dental Caries in Children. A Radiographic Study

Moca

Vaida

Negruțiu

et al. 2021

JCM

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Dental caries is a chronic disease that can be influenced by a multitude of factors. Poor oral hygiene and unhealthy eating habits are the most incriminating factors in the onset of dental caries, but age has been proven to impact the disease. The aim of this study was to find correlations between age and the evolution of dental caries in the first permanent molars in children. The retrospective study was conducted based on 400 panoramic radiographs, belonging to Romanian children between the ages of 6 and 14 years. All first permanent molars were investigated, and the carious lesions were classified according to their depth. The chronological age was calculated by subtracting the patient’s date of birth from the date when the radiograph was performed, while for the assessment of dental age, the Demirjian method was used. The gender of the patients did not significantly influence the number of superficial, medium, and deep carious lesions. Most of the identified carious lesions were superficial. Regarding correlations between age and dental caries, there was an association between the decrease in the chronological age and the increase in the number of superficial carious lesions on the first permanent molars and also an association between the increase in the chronological age or dental age and the increase in the number of medium and deep carious lesions on the first permanent molars. Age can impact the development of dental caries in first permanent molars.

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Section: Discussionmentioning

confidence: 99%

The Influence of Age on the Development of Dental Caries in Children. A Radiographic Study

Moca

Vaida

Negruțiu

et al. 2021

JCM

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“…Dysgeusia and xerostomia (early symptoms associated with SARS-CoV-2 infection) [ 195 , 207 , 208 , 209 ], but also some oral manifestations such as tongue ulcers [ 210 ], could be related to the presence of SARS-CoV-2 invasion factors (such as ACE2 and TMPRSS2) on the taste buds and dorsal tongue [ 196 ]. Interestingly, the expression of ACE2 and TMPPRSS2 in gingival sulcular epithelium (directly linked to gingivitis or periodontitis) [ 191 ], and the detection of SARS-CoV-2 in the inflammatory gingival crevicular fluid [ 211 ], raise questions on the possible role of this epithelium in SARS-CoV-2 infection.…”

Section: Sars-cov-2 Transmission and Oral Cavitymentioning

confidence: 99%

COVID-19 and Dentistry in 72 Questions: An Overview of the Literature

Derruau

Bouchet

Nassif

et al. 2021

JCM

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The outbreak of Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has significantly affected the dental care sector. Dental professionals are at high risk of being infected, and therefore transmitting SARS-CoV-2, due to the nature of their profession, with close proximity to the patient’s oropharyngeal and nasal regions and the use of aerosol-generating procedures. The aim of this article is to provide an update on different issues regarding SARS-CoV-2 and COVID-19 that may be relevant for dentists. Members of the French National College of Oral Biology Lecturers (“Collège National des EnseignantS en Biologie Orale”; CNESBO-COVID19 Task Force) answered seventy-two questions related to various topics, including epidemiology, virology, immunology, diagnosis and testing, SARS-CoV-2 transmission and oral cavity, COVID-19 clinical presentation, current treatment options, vaccine strategies, as well as infection prevention and control in dental practice. The questions were selected based on their relevance for dental practitioners. Authors independently extracted and gathered scientific data related to COVID-19, SARS-CoV-2 and the specific topics using scientific databases. With this review, the dental practitioners will have a general overview of the COVID-19 pandemic and its impact on their practice.

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“…191,192 Endocrine cells and hPSC-derived β-cells are susceptible to SARS-CoV-2 infection in vitro . 11,13,149,191 Interestingly, recent evidence suggests that SARS-CoV-2 infection might decrease insulinpositivity in β-cells driving them to degranulation and dedifferentiation in patients with severe COVID-19. 191…”

Section: Kidney and Urinementioning

confidence: 99%

Pathophysiology of infection with SARS‐CoV‐2—What is known and what remains a mystery

Sridhar

Nicholls

2021

Respirology

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Coronavirus disease 2019 (COVID-19), caused by coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused extensive disruption and mortality since its recent emergence. Concomitantly, there has been a race to understand the virus and its pathophysiology. The clinical manifestations of COVID-19 are manifold and not restricted to the respiratory tract. Extrapulmonary manifestations involving the gastrointestinal tract, hepatobiliary system, cardiovascular and renal systems have been widely reported. However, the pathophysiology of many of these manifestations is controversial with questionable support for direct viral invasion and an abundance of alternative explanations such as pre-existing medical conditions and critical illness. Prior research on SARS-Co-V and NL63 was rapidly leveraged to identify angiotensin-converting enzyme 2 (ACE2) receptor as the key cell surface receptor for SARS-CoV-2. The distribution of ACE2 has been used as a starting point for estimating vulnerability of various tissue types to SARS-CoV-2 infection. Sophisticated organoid and animal models have been used to demonstrate such infectivity of extrapulmonary tissues in vitro, but the clinical relevance of these findings remains uncertain. Clinical autopsy studies are typically small and inevitably biased towards patients with severe COVID-19 and prolonged hospitalization. Technical issues such as delay between time of death and autopsy, use of inappropriate antibodies for paraffin-embedded tissue sections and misinterpretation of cellular structures as virus particles on electron micrograph images are additional problems encountered in the extant literature. Given that SARS-CoV-2 is likely to circulate permanently in human populations, there is no doubt that further work is required to clarify the pathobiology of COVID-19.

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How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease

Cited by 28 publications

References 49 publications

The Influence of Age on the Development of Dental Caries in Children. A Radiographic Study

The Influence of Age on the Development of Dental Caries in Children. A Radiographic Study

COVID-19 and Dentistry in 72 Questions: An Overview of the Literature

Pathophysiology of infection with SARS‐CoV‐2—What is known and what remains a mystery

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