How to Bridge the Gap Between Membrane Biology and Polymer Science

Ringsdorf, Helmut; Schmidt, B

doi:10.1007/978-94-009-4712-2_25

Cited by 5 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extensive studies of grafted polymers were motivated by their potential applications in biological materials, such as liposomes [35][36][37][38]. These become now main tools in biology, biochemistry and medicine (as drugs transport agents).…”

Section: Lst Between Phospholipids and Grafted Polymer Chainsmentioning

confidence: 99%

Organization of Lipid Molecules within Biomembranes

Benhamou¹

2008

Lipid�Insights

View full text Add to dashboard Cite

Abstract:In this review, we report on the organization of lipid molecules forming biomembranes. More precisely, the question is how these amphiphiles phase separate under a change of a suitable parameter, like temperature, pressure or membrane environment. The mixture may undergo a lateral or transversal phase separations. This essentially depends on two principal factors, which are the structure (length) of hydrocarbon chains of lipid molecules and the curvature asymmetry of membranes. When the former dominates, a lateral separation is then expected. In contrary, for those biomembranes of high curvature asymmetry, a vertical separation is rather observed. We examine the problem from a static (phase diagrams) and kinetics (relaxation in time) point of view. Finally, the discussion is also extended to the phase separation between lipid molecules and cholesterol in biomembranes (formation of rafts), between phospholipids and grafted polymers on liposomes, or between surfactant and its co-surfactant in bilayer systems.

show abstract

Section: Lst Between Phospholipids and Grafted Polymer Chainsmentioning

confidence: 99%

Organization of Lipid Molecules within Biomembranes

Benhamou¹

2008

Lipid�Insights

View full text Add to dashboard Cite

show abstract

“…The study of grafted polymers on soft interfaces was motivated by the fact that they have potential applications in biological materials, such as liposomes [5][6][7][8]. These soft materials were discovered by A Bangham.…”

Section: Introductionmentioning

confidence: 99%

An extended study of the phase separation between phospholipids and grafted polymers on a bilayer biomembrane

Benhamou¹,

Joudar²,

Kaidi³

et al. 2011

Phys. Scr.

View full text Add to dashboard Cite

We re-examine here the phase separation between phospholipids and adsorbed polymer chains on a fluid membrane with a change in some suitable parameter (temperature). Our purpose is to quantify the significant effects of the solvent quality and of the polydispersity of adsorbed loops formed by grafted polymer chains on the segregation phenomenon. To this end, we elaborate on a theoretical model that allows us to derive the expression for the mixing free energy. From this, we extract the phase diagram shape in the composition–temperature plane. Our main conclusion is that the polymer chain condensation is very sensitive to the solvent quality and to the polydispersity of loops of adsorbed chains.

show abstract

Functional Cell Adhesion Receptors (Integrins) in Polymeric Architectures

et al. 2015

View full text Add to dashboard Cite

Integrins, as transmembrane heterodimeric receptors, have important functions in cell adhesion, migration, proliferation, survival apoptosis and signal transduction, in many physio- as well as pathophysiological settings. Characterisation of integrins and their ligand/antagonist binding is notoriously difficult, due to high integrin redundancy and ubiquity. Bypassing the intrinsic difficulties of cell-based integrin expression, purification and reconstitution, we present for the first time the synthesis of a heterodimeric integrin receptor and its assembly into a block-copolymeric membrane mimic. We present comprehensive data to demonstrate the synthesis of functionally active integrin αv β3, generated by in vitro membrane-assisted protein synthesis (iMAPS). This work represents the first step towards a robust and adaptable polymer-based platform for characterisation of integrin-ligand interactions.

show abstract

How to Bridge the Gap Between Membrane Biology and Polymer Science

Cited by 5 publications

References 33 publications

Organization of Lipid Molecules within Biomembranes

Organization of Lipid Molecules within Biomembranes

An extended study of the phase separation between phospholipids and grafted polymers on a bilayer biomembrane

Functional Cell Adhesion Receptors (Integrins) in Polymeric Architectures

Contact Info

Product

Resources

About