How to Assess Fibrinogen Levels and Fibrin Clot Properties in Clinical Practice?

Undas, Anetta

doi:10.1055/s-0036-1579636

Cited by 55 publications

(56 citation statements)

References 63 publications

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“…69 Similar findings in fibrin architecture and properties were observed in patients with ischemic stroke, 70,71 peripheral vascular disease, 72 deep vein thrombosis, 73 and so on. 74 The common organization and properties of fibrin clots from the blood of patients with various types of thrombotic complications suggest direct participation of fibrin in the pathogenesis of both arterial and venous thrombosis.…”

Section: Fibrin Is Important In Venous and Arterial Thromboses Fibrinmentioning

confidence: 99%

What Is the Biological and Clinical Relevance of Fibrin?

Litvinov

Weisel

2016

Semin Thromb Hemost

107

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As our knowledge of the structure and functions of fibrinogen and fibrin has increased tremendously, several key findings have given some people a superficial impression that the biological and clinical significance of these clotting proteins may be less than earlier thought. Most strikingly, studies of fibrinogen knockout mice demonstrated that many of these mice survive to weaning and beyond, suggesting that fibrin(ogen) may not be entirely necessary. Humans with afibrinogenemia also survive. Furthermore, in recent years, the major emphasis in the treatment of arterial thrombosis has been on inhibition of platelets, rather than fibrin. In contrast to the initially apparent conclusions from these results, it has become increasingly clear that fibrin is essential for hemostasis; is a key factor in thrombosis; and plays an important biological role in infection, inflammation, immunology, and wound healing. In addition, fibrinogen replacement therapy has become a preferred, major treatment for severe bleeding in trauma and surgery. Finally, fibrin is a unique biomaterial and is used as a sealant or glue, a matrix for cells, a scaffold for tissue engineering, and a carrier and/or a vector for targeted drug delivery.

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Section: Fibrin Is Important In Venous and Arterial Thromboses Fibrinmentioning

confidence: 99%

What Is the Biological and Clinical Relevance of Fibrin?

Litvinov

Weisel

2016

Semin Thromb Hemost

107

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“…Perhaps minimal hemolysis, or a slight dilution of the blood by fluid movement into the umbilical vein, could explain the slight fall in hemoglobin, while demargination might explain the slight increase in leukocyte and platelet counts [9, 10]. Coagulation does not appear to be a significant factor in these slight changes at 30 min, because the fibrinogen concentration did not fall [11]. …”

Section: Discussionmentioning

confidence: 99%

Evaluating Otherwise-Discarded Umbilical Cord Blood as a Source for a Neonate’s Complete Blood Cell Count at Various Time Points

et al. 2018

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Background: Previous studies have reported the use of cord blood for admission laboratory complete blood counts (CBCs). However, no studies have investigated its stability for the first 30 min after delivery. Objectives: We quantified blood cells drawn from the umbilical vein to determine the effect of (1) the time after placental delivery, and (2) the site of blood sampling (umbilical vein on an isolated cord segment vs. umbilical vein on the placental surface). Methods: Timed phlebotomies were drawn at 2, 10, and 30 min from (1) the umbilical vein on an isolated, double-clamped cord segment, and (2) the umbilical vein near or on the placental surface. Leukocyte count, hemoglobin, platelet count, and fibrinogen were measured on each phlebotomy sample. Results: Blood drawn from the isolated umbilical cord segments had leukocyte count, hemoglobin, platelet count, and fibrinogen that remained unchanged between the phlebotomies at 2, 10, and 30 min after delivery. However, blood drawn from the umbilical vein on the placental surface had, at 30 min, a leukocyte count (p = 0.002), hemoglobin (p = 0.01), and platelet count (p = 0.001) that were statistically different from the values at 2 and 10 min after delivery. There was no difference in fibrinogen at 2, 10, or 30 min. Conclusions: If cord blood is used for a neonate’s initial CBC, the blood should be drawn within 10 min of the placental delivery when it is taken from the umbilical vein on or near the placenta. If an umbilical cord segment is obtained, the phlebotomy can be delayed for up to 30 min.

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“…Fibrinogen determination is one of the most common coagulation tests for investigation of coagulation state or diagnosis of hemorrhagic disorders . Many different methods could be used for fibrinogen determination, including Clauss method, PT‐derived method, and immunological fibrinogen assay et al . The Clauss method is based on the clotting time measured by adding high concentration of thrombin to diluted plasma, which might be the most commonly used by now .…”

Section: Introductionmentioning

confidence: 99%

“…The PT‐Fg is estimated based on the change in coagulation signal during the performance of a standard PT assay . The immunoassay is based on antigen‐antibody reaction, which provides quantitative results with less influences …”

Section: Introductionmentioning

confidence: 99%