How to Approach Neutropenia in Childhood

Walkovich, Kelly; Boxer, Laurence A.

doi:10.1542/pir.34-4-173

Cited by 50 publications

(58 citation statements)

References 10 publications

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“…Currently, the risk of infection is successfully reduced with G-CSF. However, G-CSF is recommended to be used in cases of repetetive infection complications because of the benign character of the disease (1,(3)(4)(5)(6).…”

Section: Chronic Benign Neutropeniamentioning

confidence: 99%

“…After the age of one year the lower limit is 1 500/mm 3 . In the black race, this limit is accepted to be 1200/mm 3 (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Neutropenias are classified by absolute neutrophil count as follows: 1 000-1 500/mm 3 : mild neutropenia 500 -1 000/mm 3 : moderate neutropenia <500/mm 3 : severe neutropenia <100/mm 3 : very severe neutropenia (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…It has been stated that correction of neutropenia even following a simple event may last for up to 8-12 months. Therefore, it is thought that calling neutropenia "chronic" before 6 months is not very appropriate (1,(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

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Approach to the patient with neutropenia in childhood

Çelkan

Koç

2015

Turk Pediatri Ars

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Neutrophils have an important role in host defense and acute inflammation. It is well known that susceptibility to infection increases when the neutrophil count is low. Neutropenia were classified as mild, moderate and severe according to the neutrophil counts, or acute and chronic depending on the duration of neutropenia, or congenital and acquired according to the mechanism. The patients with neutropenia are clinically different due to underlying mechanism, they have life-threatening infections or no infection may be observed. The most common cause of acquired neutropenia is viral infection, followed by drugs and autoimmune neutropenia. Congenital neutropenia are usually diagnosed by acute and life-threatening invasive bacterial and fungal infections. Immune system disorders and other systemic abnormalities may be accompanied or not. Recent years, novel single gen defects causing congenital neutropenia were defined through advanced genetic techniques. Molecular diagnosis is useful for risk stratification, choice of therapy and prognosis on follow-up. This review was prepared for pediatricians as a guide focused on approach neutropenia, which tests should be performed and when should be referred to a specialist. (Turk Pediatri Ars 2015; 50: 136-44)

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Section: Chronic Benign Neutropeniamentioning

confidence: 99%

“…After the age of one year the lower limit is 1 500/mm 3 . In the black race, this limit is accepted to be 1200/mm 3 (3,4).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Approach to the patient with neutropenia in childhood

Çelkan

Koç

2015

Turk Pediatri Ars

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“…1 Reviews on the diagnosis and treatment of the neutropenic child have been published recently. 2,3 However, the spectrum of diseases causing NP is different in children compared to adults, mainly because congenital disorders predominate in pediatric clinical experience, whereas other hematologic disorders, autoimmune and chronic viral diseases, and drug-induced agranulocytosis constitute the majority of cases in adults.…”

mentioning

confidence: 99%

How we diagnose neutropenia in the adult and elderly patient

2014

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Increased nutrition risk is associated with a prolonged negative conversion of viral RNA in children and adolescents with COVID‐19

Cai

Huang

et al. 2023

Nut in Clin Prac

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BackgroundThis study aimed to determine the factors affecting the time to negative conversion of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in children and adolescents, with particular reference to nutrition risk assessment on admission.MethodsThis retrospective observational study was conducted in a sentinel hospital for novel coronavirus in Quanzhou, China. The study population comprised children and adolescents with COVID‐19 admitted to the isolation wards between March 25 and April 12, 2022. Based on the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP), nutrition risk screening was performed within 24 h of admission. Univariate and multivariate analyses were used to identify independent factors for the time to negative viral RNA conversion.ResultsA total of 185 patients with confirmed COVID‐19 were included in this study. The median time to viral RNA conversion (from the first day of a positive nucleic acid test to the first day of consecutive negative results) was 15 days (IQR 12–18 days), ranging from 4 to 25 days. High nutrition risk (hazard ratio [HR]: 0.543, 95% CI: 0.334–0.881) and fever (HR: 0.663; 95% CI: 0.483–0.910) were independent factors influencing the negative conversion of SARS‐CoV‐2 RNA.ConclusionHigh nutrition risk and fever were independently associated with delayed viral clearance in children and adolescents with SARS‐CoV‐2 infection, so these factors should be considered during the treatment plans for infected children and adolescents.

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How to Approach Neutropenia in Childhood

Cited by 50 publications

References 10 publications

Approach to the patient with neutropenia in childhood

Approach to the patient with neutropenia in childhood

How we diagnose neutropenia in the adult and elderly patient

Increased nutrition risk is associated with a prolonged negative conversion of viral RNA in children and adolescents with COVID‐19

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