How to adjust endoscopic findings to histopathological findings of the stomach: a “histopathology-oriented” correspondence method helps to understand endoscopic findings

Fujita, Yuka; Kishimoto, Mitsuo; Dohi, Osamu; Kamada, Kazuhiro; Majima, Atsushi; Kimura-Tsuchiya, Reiko; Yagi, Nobuaki; Konishi, Hideyuki; Naito, Yuji; Harada, Yoshinori; Tanaka, Hideo; Konishi, Eiichi; Sugai, Tamotsu; Yanagisawa, Akio

doi:10.1007/s10120-017-0762-1

Cited by 3 publications

(2 citation statements)

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“…Yao et al examined the detailed relationship between endoscopic and histological findings by investigating the length of the intervening section and the depth of the glands (3). Fujita et al described a systematic process, the KOTO method, which allows detailed adjustments of endoscopic findings to match histopathological findings (32). The present study demonstrated that our light transmission-assisted pathological examination helped endoscopists and pathologists to easily and accurately understand the nature, depth, and extent of the lesions.…”

Section: Discussionmentioning

confidence: 55%

“…Fujita et al. described a systematic process, the KOTO method, which allows detailed adjustments of endoscopic findings to match histopathological findings ( 32 ). The present study demonstrated that our light transmission-assisted pathological examination helped endoscopists and pathologists to easily and accurately understand the nature, depth, and extent of the lesions.…”

Section: Discussionmentioning

confidence: 99%

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A Parallel Comparison Method of Early Gastric Cancer: The Light Transmission-Assisted Pathological Examination of Specimens of Endoscopic Submucosal Dissection

Chen

Yue

et al. 2021

Front. Oncol.

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ObjectiveIt is always challenging to diagnose and characterize early gastric cancer surrounded by non-cancerous mucosa, including the malignant diagnosis and extent and depth of the lesions. Therefore, we developed a light transmission-assisted pathological examination to diagnose and characterize early gastric cancer. Here, we performed a parallel comparison between the light transmission-assisted pathological examination under endoscopy and the histological examination for the diagnosis of early gastric cancer.MethodsFirst, the endoscopic submucosal dissection (ESD) specimen was first placed on the surface of the light-emitting diode lamp to observe the mucosal surface structure and blood vessels. Second, the sliced and embedded tissue strips were cut into 3-µm sections for hematoxylin and eosin staining. Third, the histopathology of each section was projected onto a macroscopic image. Finally, the macroscopic and microscopic changes in the ESD specimens observed under endoscopy were compared. Seventy cases of early gastric adenocarcinoma were diagnosed and characterized using this new method.ResultsUsing the conventional pathological method, the demarcation line of the lesions was seen in 40 of 70 (57.1%) cases. Furthermore, no surface structure or microvascular changes were observed in any of the cases. Based on the light transmission-assisted pathological examination, 58 of 70 (82.9%) cases presented clear edges of neoplastic and non-neoplastic epithelia, with a classifiable surface structure (88.6%) and microvascular type (78.8%).ConclusionsThis pilot method provided a practical bridge between endoscopic and pathological examinations. Compared to the histological examination, the light transmission-assisted pathological examination was an easier and more precise way to match the in vivo endoscopic observation and in vitro pathological examination.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%