How the Internally Organized Direction Sense Is Used to Navigate

Park, Eun Hye; Keeley, Stephen; Savin, Cristina; Ranck, James B.; Fenton, A. G.

doi:10.1016/j.neuron.2018.11.019

Cited by 25 publications

(31 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Future computational work could thus also further consider networks in which the speed component of the velocity input combined with sensory-driven adjustments to the phase of the grid network drive the grid rescaling observed after environmental perturbations 12,24,25,40 . Finally, the bimodal nature of the head direction organization we observed raises the possibility that MEC head direction cells provide directional information that is relative to an internal reference frame 41 . This type of code is reminiscent of head direction signals in retrosplenial cortex, a brain region with strong reciprocal MEC connections, and that contains bidirectional head direction cells that anchor their preferred firing angle to local landmarks 42 .…”

Section: Discussionmentioning

confidence: 73%

Entorhinal velocity signals reflect environmental geometry

et al. 2020

View full text Add to dashboard Cite

The entorhinal cortex contains neurons that represent self-location, including grid cells that fire in periodic locations and velocity signals that encode running speed and head direction. While the size and shape of the environment influences grid patterns, whether entorhinal velocity signals are equally influenced or provide a universal metric for self-motion across environments remains unknown. Here, we report that speed cells rescale after changes to the size and shape of the environment. Moreover, head direction cells reorganize in an experience-dependent manner to align with the axis of environmental change. A knockout mouse model allows a dissociation of the coordination between cell types, with grid and speed, but not head direction, cells responding in concert to environmental change. These results point to malleability in the coding features of multiple entorhinal cell types and have implications for which cell types contribute to the velocity signal used by computational models of grid cells.

show abstract

Section: Discussionmentioning

confidence: 73%

Entorhinal velocity signals reflect environmental geometry

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Our observations of multistable frame-specific positional and directional population discharge, and persistence of internally-organized cofiring discharge relationships (Kelemen and Fenton, 2010;Talbot et al, 2018;van Dijk and Fenton, 2018;Park et al, 2019) can be readily accommodated by the information maximization (Infomax) perspective that is a dominant conceptualization of how information processing is serially organized across connected neuronal networks with related input-output functions (Bell and Sejnowski, 1997;Linsker, 1997), such as the MEC and hippocampal computations of environmental space (Solstad et al, 2006).…”

Section: Do Signaling Games Offer Anything That Information Maximizat...mentioning

confidence: 89%

“…Furthermore, Infomax concepts are severely challenged to explain our additional observation that the cofiring relationships between simultaneously-recorded hippocampal and MEC neurons (Fig. 4C bottom) is only weakly persistent across the stable and rotating arena conditions, despite both the entorhinal (Park et al, 2019) and the hippocampal populations each exhibiting strongly persistent, attractor-like cofiring relationships (Levy et al, 2021). If MEC representations of space project to hippocampus then their discharge should be informationally coupled, and the discharge representations should be informationally coherent, perhaps even increasing in fidelity according to Infomax predictions.…”

Section: Do Signaling Games Offer Anything That Information Maximizat...mentioning

confidence: 99%

“…But as Fig. 4C suggests, the discharge coupling is unstable, and the frame-specfic multistability in hippocampus (Kelemen and Fenton, 2010;van Dijk and Fenton, 2018) is observed to have a different, weakly opposite relationship to frame-specific behavior as is observed for MEC frame-specific multistability (Park et al, 2019). Because it is difficult to reconcile these observations within the Infomax framework, we were motivated to seek an alternative.…”

Section: Do Signaling Games Offer Anything That Information Maximizat...mentioning

confidence: 99%

“…APPENDIX 1: Methods There procedures were previously described in detail (Park et al, 2019), and are here provided in brief to complement the data reported in Figure 4.…”

Section: Wrapping Upmentioning

confidence: 99%

See 2 more Smart Citations

Do place cells dream of deceptive moves in a signaling game?

Fenton

Hurtado

Broek

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

We consider the possibility of applying game theory to analysis and modeling of neurobiological systems. Specifically, the basic properties and features of information asymmetric signal games are considered and discussed as having potential to explain diverse neurobiological phenomena at levels of biological function that include gene regulation, molecular and biochemical signaling, cellular and metabolic function, as well as neuronal action potential discharge to represent cognitive variables that may underlie memory and behavior. We begin by arguing that there is a pressing need for conceptual frameworks that can permit analysis and integration of information and explanations across the many scales of diverse levels of biological function if we are to understand cognitive functions like learning, memory, and perception. The present work focuses on systems level neuroscience organized around the connected brain regions of the entorhinal cortex and hippocampus. These areas are intensely studied in rodent subjects as model neuronal systems that undergo activity-dependent synaptic plasticity to form and represent memories and spatial knowledge used for purposeful navigation. Examples of cognition-related spatial information in the observed neuronal discharge of hippocampal place cell populations and medial entorhinal head-direction cell populations are used to illustrate possible challenges to information maximization concepts that may be natural to explain using the ideas and features of information asymmetric signaling games.

show abstract

Is hippocampal remapping the physiological basis for context?

2019

View full text Add to dashboard Cite

In 1980, Nadel and Wilner extended Richard Hirsh's notion that the hippocampus creates environmental representations, called “contexts,” suggesting that the fundamental structure of context was the spatial representation proposed by O'Keefe and Nadel's landmark book, The Hippocampus as a Cognitive Map (1978). This book, in turn, derives from the discovery that individual hippocampal neurons act as place cells, with the complete set of place cells tiling an enclosure, forming a type of spatial map. It was found that unique environments had unique place cell representations. That is, if one takes the hippocampal map of a specific environment, this representation scrambles, or “remaps” when the animal is placed in a different environment. Several authors have speculated that “maps” and “remapping” form the physiological substrates for context and context shifting. One difficulty with this definition is that it is exclusively spatial; it can only be inferred when an animal locomotes in an enclosure. There are five aims for this article. The first is to give an historical overview of context as a variable that controls behavior. The second aim is to give an historical overview of concepts of place cell maps and remapping. The third aim is to propose an updated definition of a place cell map, based on temporal rather than spatial overlaps, which adds flexibility. The fourth aim is to address the issue of whether the biological phenomenon of hippocampal remapping, is, in fact, the substrate for shifts in the psychological phenomenon of context. The final aim is speculation of how contextual representations may contribute to effective behavior.

show abstract

How the Internally Organized Direction Sense Is Used to Navigate

Cited by 25 publications

References 66 publications

Entorhinal velocity signals reflect environmental geometry

Entorhinal velocity signals reflect environmental geometry

Do place cells dream of deceptive moves in a signaling game?

Is hippocampal remapping the physiological basis for context?

Contact Info

Product

Resources

About