How the genomics revolution could finally help Africa

Nordling, Linda

doi:10.1038/544020a

Cited by 34 publications

(27 citation statements)

References 5 publications

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“…These very promising results support the intriguing vision of genomics as a tool to reach precision public health also in the African continent . Thanks to the H3Africa initiative and the TrypanoGen network, the number of publications arising from genomics investigations are increasing.…”

Section: Genomics To Study Susceptibility To Hatmentioning

confidence: 63%

Sleeping Sickness in the ‘Omics Era

Tiberti

Sanchez

2018

Proteomics Clinical Apps

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Sleeping sickness is a neglected tropical disease caused by Trypanosoma brucei parasites, affecting the poorest communities in sub-Saharan Africa. The great efforts done by the scientific community, local governments, and non-governmental organizations (NGOs) via active patients' screening, vector control, and introduction of improved treatment regimens have significantly contributed to the reduction of human African trypanosomiasis (HAT) incidence during the last 15 years. Consequently, the WHO has announced the objective of HAT elimination as a public health problem by 2020. Studies at both parasite and host levels have improved our understanding of the parasite biology and the mechanisms of parasite interaction with its mammalian host. In this review, the impact that 'omics studies have had on sleeping sickness by revealing novel properties of parasite's subcellular organelles are summarized, by highlighting changes induced in the host during the infection and by proposing potential disease markers and therapeutic targets.

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Section: Genomics To Study Susceptibility To Hatmentioning

confidence: 63%

Sleeping Sickness in the ‘Omics Era

Tiberti

Sanchez

2018

Proteomics Clinical Apps

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“…The introduction of genomic technology in LMICs is expanding capacity in clinical genetic testing and genomic research with the potential to revolutionize the understanding, care, and clinical treatment for communicable and noncommunicable diseases. [180][181][182] However, without sufficient attention paid to the ethical, social, and cultural implications of such services, technological advances may fall short of their potential. Our narrative synthesis uncovered a number of ethical, social, and cultural issues that are associated with genetic services in LMICs, with implications for implementation and delivery of such services.…”

Section: Discussionmentioning

confidence: 99%

Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review

Zhong

Darren

Loiseau

et al. 2021

Genetics in Medicine

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“…It must also maintain practicality and clinical relevance to the local patient population. The H3Africa initiative has recently published guidelines for researchers wishing to do research in the African continent which are aimed at empowering local scientists and ensuring benefit for African patients ( 5 ). Developing home-grown expertise in polyomic technologies in LMICs would also have economic benefits in addition to building the global laboratory medicine workforce of the future.…”

Section: Barriers To Global Research In Precision Medicinementioning

confidence: 99%

“…There is clear evidence that basic cellular processes vary across different human populations ( 3 , 4 ). Despite this, only 3% of genome-wide association studies have been performed in Africans, without considering sequencing studies ( 5 , 6 ). Evidence in HICs from studies comparing individuals from different ancestries has found that despite controlling for socioeconomic factors and other environmental exposures, there is still a large disparity in cancer incidence and outcomes that remains to be addressed ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Global Inequities in Precision Medicine and Molecular Cancer Research

2018

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Precision medicine based upon molecular testing is heralded as a revolution in how cancer is prevented, diagnosed, and treated. Large efforts across the world aim to conduct comprehensive molecular profiling of disease to inform preclinical models, translational research studies and clinical trials. However, most studies have only been performed in patients from high-income countries. As the burden on non-communicable diseases increases, cancer will become a pressing burden across the world, disproportionately affecting low-middle income settings. There is emerging evidence that the molecular landscape of disease differs geographically and by genetic ancestry, which cannot be explained by environmental factors alone. There is a lack of good quality evidence that characterises the molecular landscape of cancers found in low-middle income countries. As cancer medicine becomes increasingly driven by molecular alterations in high-income settings, low-income settings may become left behind. Further efforts on an international scale must be made by researchers, funders, and policymakers to ensure cancer research addresses disease across the world, so models are not limited to subtypes of disease found in high-income countries. In this review, we discuss differences found in the molecular profiles of tumours worldwide and the implication this has for the future of global cancer care. Finally, we identify several barriers currently limiting progress in this field and innovative solutions, which may address these shortcomings.

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How the genomics revolution could finally help Africa

Cited by 34 publications

References 5 publications

Sleeping Sickness in the ‘Omics Era

Sleeping Sickness in the ‘Omics Era

Ethical, social, and cultural issues related to clinical genetic testing and counseling in low- and middle-income countries: a systematic review

Global Inequities in Precision Medicine and Molecular Cancer Research

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