How technetium could help some PET nuclear chemistry technology: application of Tc-99 NMR for analysis of O-18 content in water

Tarasov, V. P.; Kirakosyan, G. A.; German, K. É.

doi:10.1016/j.nucmedbio.2014.05.125

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present paper, we report an alternative method for the evaluation of the oxygen isotope composition of water, namely, 99 Tc NMR . The suggested approach is based on the effect of the oxygen isotope composition of the TcO 4 − anion on 99 Tc NMR parameters.…”

Section: Introductionmentioning

confidence: 99%

“…[2] A rapid online technique suggested by Farquhar et al [3] for analysis of oxygen isotopes in nitrogen-containing organic matter and water is based on pyrolysis over nickelized carbon and conversion to carbon monoxide with subsequent mass spectrometric measurement of the 18 O/ 16 O ratio. A yet another method of determination of oxygen-18 content of water does not require gas handling and consists of the hydrolysis of PCl 5 and measurement by gas chromatography and mass spectrometry with selected ion monitoring. [4] In the present paper, we report an alternative method for the evaluation of the oxygen isotope composition of water, namely, 99 Tc NMR.…”

Section: Introductionmentioning

confidence: 99%

“…[4] In the present paper, we report an alternative method for the evaluation of the oxygen isotope composition of water, namely, 99 Tc NMR. [5,6] The suggested approach is based on the effect of the oxygen isotope composition of the TcO 4 − anion on 99 Tc NMR parameters. At ambient temperature, the isotope shift of 99 Tc NMR lines for a single 16 O→ 18 O substitution is −0.43 ± 0.01 ppm.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

⁹⁹Tc NMR determination of the oxygen isotope content in ¹⁸O‐enriched water

Тарасов

Kirakosyan

German

2017

Magnetic Reson in Chemistry

View full text Add to dashboard Cite

Tc NMR has been suggested as an original method of evaluating the content of oxygen isotopes in oxygen-18-enriched water, a precursor for the production of radioisotope fluorine-18 used in positron emission tomography. To this end, solutions of NH TcO or NaTcO (up to 0.28 mol/L) with natural abundance of oxygen isotopes in virgin or recycled O-enriched water have been studied by Tc NMR. The method is based on O/ O/ O intrinsic isotope effects in the Tc NMR chemical shifts, and the statistical distribution of oxygen isotopes in the coordination sphere of TcO and makes it possible to quantify the composition of enriched water by measuring the relative intensities of the Tc NMR signals of the Tc O O isotopologues. Because the oxygen exchange between TcO and enriched water in neutral and alkaline solutions is characterized by slow kinetics, gaseous HCl was bubbled through a solution for a few seconds to achieve the equilibrium distribution of oxygen isotopes in the Tc coordination sphere without distortion of the oxygen composition of the water. Pertechnetate ion was selected as a probe due to its high stability in solutions and the significant Tc NMR shift induced by a single O→ O substitution (-0.43 ± 0.01 ppm) in TcO and spin coupling constant J( Tc- O) (131.46 Hz) favourable for the observation of individual signals of Tc O O isotopologues.

show abstract

Section: Introductionmentioning

confidence: 99%