“…These include the β-catenin dependent or “canonical” Wnt signaling pathway, the Wnt planar cell polarity (PCP) pathway, and the Ca 2+ /Calmodulin pathway (Sokol, 2015, Gao and Chen, 2010). Though Wnt/PCP is often associated with polarizing cells in various contexts including vertebrate convergent extension and the fly eye and wing bristle (Axelrod et al, 1996, Wehrli and Tomlinson, 1998, Klein and Mlodzik, 2005, Gao, 2012) and the Wnt/Ca2+ pathway also polarizes cell movements during gastrulation (Lin et al, 2010), the Wnt/β-catenin canonical pathway regulates mother cell polarity at the time of division and subsequent asymmetry of newly-formed daughter cells in addition to its a well-established role in transcriptional activation, cell proliferation, differentiation and stem cell maintenance (Habib et al, 2013, Sawa and Korswagen, 2013, Murgan and Bertrand, 2015, Munro and Bowerman, 2009, Hardin and King, 2008). …”