How T'reg‐ulate healing of the injured spinal cord?

Milling, Simon; Edgar, Julia M.

doi:10.1111/imm.13148

Cited by 9 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recovery of olfactory function was associated with the increase of SIRT4 expression 27 . SIRT4 can inhibit the anti‐inflammatory activity of Tregs infiltrating the spinal cord after injury 28 . In the present study, we proved that the decreased TNF‐α, NLRP3, and IL‐1β caused by WY were elevated by siSIRT4.…”

Section: Discussionsupporting

confidence: 61%

See 1 more Smart Citation

Improvement of neurological recovery in the insomnia rats by Warming Yang Strategy through targeting SIRT4 by inhibiting inflammation and apoptosis

Liu

Rao

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

The incidence rate of insomnia is increasing, but the mechanism of it remains unclear. Warming Yang Strategy (WY) is a kind of Traditional Chinese Medicine, and it is proved to be effective in treating insomnia patients. The insomnia animal was established with chlorophenylalanine (PCPA). Morris water maze and open field test were performed to evaluate the influence of WY on the neurological recovery of insomnia rats. TUNEL staining and flow cytometry were used to measure apoptosis level. WY promoted the neurological recovery in the insomnia rats through Morris water maze and open field test evaluation. The increase of γ‐aminobutyric acid, dopamine, 5‐hydroxytryptamine, and norepinephrine caused by WY was suppressed by siSIRT4. The decrease of apoptosis and inflammation factors expression induced by WY was promoted by siRNA‐SIRT4 (siSIRT4). WY improve neurological recovery in the insomnia rats through SIRT4 by inhibiting inflammation and apoptosis. This research might provide a novel insight for the prevention and treatment of insomnia through targeting SIRT4.

show abstract

Section: Discussionsupporting

confidence: 61%

“…27 SIRT4 can inhibit the anti-inflammatory activity of Tregs infiltrating the spinal cord after injury. 28 In the present study, we proved that the decreased TNFα, NLRP3, and IL-1β caused by WY were elevated by siSIRT4. These results indicated that the regulation of inflammation by WY might be achieved through SIRT4.…”

Section: Bioinformatics Analysissupporting

confidence: 61%

Improvement of neurological recovery in the insomnia rats by Warming Yang Strategy through targeting SIRT4 by inhibiting inflammation and apoptosis

Liu

Rao

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…The subpopulations of CD4 + T cells include helper T cells (Th1, Th2, and Th17) and regulatory T cells (Tregs) ( 90 ). T-cell infiltration in injured spinal cord tissues has been consistently reported in various SCI animal models ( 92 ). Jennifer et al.…”

Section: How Are the Functions Of Immune Cells And Immune Factors Orc...mentioning

confidence: 96%

The role of immune cells and associated immunological factors in the immune response to spinal cord injury

Tang¹,

Gu²,

Jiang³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Spinal cord injury (SCI) is a devastating neurological condition prevalent worldwide. Where the pathological mechanisms underlying SCI are concerned, we can distinguish between primary injury caused by initial mechanical damage and secondary injury characterized by a series of biological responses, such as vascular dysfunction, oxidative stress, neurotransmitter toxicity, lipid peroxidation, and immune-inflammatory response. Secondary injury causes further tissue loss and dysfunction, and the immune response appears to be the key molecular mechanism affecting injured tissue regeneration and functional recovery from SCI. Immune response after SCI involves the activation of different immune cells and the production of immunity-associated chemicals. With the development of new biological technologies, such as transcriptomics, the heterogeneity of immune cells and chemicals can be classified with greater precision. In this review, we focus on the current understanding of the heterogeneity of these immune components and the roles they play in SCI, including reactive astrogliosis and glial scar formation, neutrophil migration, macrophage transformation, resident microglia activation and proliferation, and the humoral immunity mediated by T and B cells. We also summarize findings from clinical trials of immunomodulatory therapies for SCI and briefly review promising therapeutic drugs currently being researched.

show abstract

“…In addition, Treg cells express the transcription factor FOXP3 in the nucleus, which is a major marker of Treg cell identity and a key molecule in the regulation of their function ( 113 , 114 ). Transforming growth factor β (TGF-β) and IL-10 are examples of the multiple inflammatory suppressive cytokines produced by Treg cells; these factors inhibit the activation and immune response of other cells, leading to immunosuppression and immunomodulation ( 115 , 116 ). Short-chain fatty acids (SCFAs) modulate Treg cells in the gut and affect the balance of Treg cells and IL-17+γδ T cells in the spinal cord, which has been reported to suppress inflammatory responses and promote locomotor function in SCI rats ( 111 ).…”

Section: Regulatory Role Of Treg Cells In Scimentioning

confidence: 99%

Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

Zhang,

Li,

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Spinal cord injury is a severe neurological trauma that can frequently lead to neuropathic pain. During the initial stages following spinal cord injury, inflammation plays a critical role; however, excessive inflammation can exacerbate pain. Regulatory T cells (Treg cells) have a crucial function in regulating inflammation and alleviating neuropathic pain. Treg cells release suppressor cytokines and modulate the function of other immune cells to suppress the inflammatory response. Simultaneously, inflammation impedes Treg cell activity, further intensifying neuropathic pain. Therefore, suppressing the inflammatory response while enhancing Treg cell regulatory function may provide novel therapeutic avenues for treating neuropathic pain resulting from spinal cord injury. This review comprehensively describes the mechanisms underlying the inflammatory response and Treg cell regulation subsequent to spinal cord injury, with a specific focus on exploring the potential mechanisms through which Treg cells regulate neuropathic pain following spinal cord injury. The insights gained from this review aim to provide new concepts and a rationale for the therapeutic prospects and direction of cell therapy in spinal cord injury-related conditions.

show abstract

How T'reg‐ulate healing of the injured spinal cord?

Cited by 9 publications

References 8 publications

Improvement of neurological recovery in the insomnia rats by Warming Yang Strategy through targeting SIRT4 by inhibiting inflammation and apoptosis

Improvement of neurological recovery in the insomnia rats by Warming Yang Strategy through targeting SIRT4 by inhibiting inflammation and apoptosis

The role of immune cells and associated immunological factors in the immune response to spinal cord injury

Impact of inflammation and Treg cell regulation on neuropathic pain in spinal cord injury: mechanisms and therapeutic prospects

Contact Info

Product

Resources

About