How stable is quantitative MRI? – Assessment of intra- and inter-scanner-model reproducibility using identical acquisition sequences and data analysis programs

Gracien, René‐Maxime; Maiworm, Michelle; Brüche, Nadine; Shrestha, Manoj; Nöth, Ulrike; Hattingen, Elke; Wagner, Marlies; Deichmann, Ralf

doi:10.1016/j.neuroimage.2019.116364

Cited by 64 publications

(69 citation statements)

References 43 publications

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“…The mean values of MT, PD, R1, and R2* (Figure 11) were generally in line with values published by Gracien et al (2019); Gringel et al (2009); Hagiwara et al (2018); Krauss et al (2015); Weiskopf et al (2013). Relaxation (R1, R2*) values deviated by 0.3–10.9% from the values reported in Weiskopf et al (2013) in GM, WM, caudate nucleus (CN), and the corpus callosum (CC).…”

Section: Discussionsupporting

confidence: 89%

“…PD values differed by 3.7–13.6% from those reported in Krauss et al (2015), considering the same ROIs. For R1, and R2* we achieved deviations between 0.3 and 21.2%, and between 1.5 and 3.8% for PD compared with Gracien et al (2019), taking only GM and WM mean values into account. MT values differed between 11 and 22% from values reported in Gringel et al (2009), whereas the deviation was only about 10% from Hagiwara et al (2018).…”

Section: Discussionmentioning

confidence: 46%

“…ROIs: Intracranial gray (GM) and white matter (WM), a sphere in the head of caudate nucleus (CN), a sphere in the corpus callosum (CC). Reference values marked by symbols (Gracien et al, 2019; Gringel et al, 2009; Hagiwara et al, 2018; Krauss, Gunnarsson, Andersson, & Thunberg, 2015; Weiskopf et al, 2013)…”

Section: Discussionmentioning

confidence: 99%

“…However, this study went beyond previous multicenter studies using quantitative mapping (Deoni et al, 2008; Gracien et al, 2019; Lee, Callaghan, Acosta‐Cabronero, Lutti, & Nagy, 2019; Weiskopf et al, 2013) by including six sites, two different manufacturers, and four different MRI scanner models. By including diverse hardware and software, this study captures the typical situation in multicenter clinical trials better and provides a more realistic reference for the performance of MPM in multicenter studies using widely available product sequences and methods.…”

Section: Discussionmentioning

confidence: 99%

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Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Leutritz

Seif

Helms

et al. 2020

Human Brain Mapping

105

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Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole‐brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI‐toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter‐site comparability, the intra‐site (i.e., scan‐rescan experiment) coefficient of variation (CoV), inter‐site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra‐ and inter‐site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra‐site CoV (16%) was observed in R2* maps. The inter‐site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Leutritz

Seif

Helms

et al. 2020

Human Brain Mapping

105

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“…However, a previous study showed that a similar protocol yielded accurate T 2 mapping with a scan-rescan deviation of about only 1.5%. 26 For FCD definition, conventional FLAIR datasets were obtained with the following acquisition parameters: matrix size = 256 × 220 × 160, isotropic resolution = 1 mm, field of view = 256 × 220 × 160 mm 3 , TE = 353 msec, TR = 5000 msec, inversion time (TI) = 1800 msec, bandwidth = 930 Hz/pixel, duration = 7 minutes 12 seconds.…”

Section: Mri Acquisition and T 2 Mappingmentioning

confidence: 99%

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

Ahmad

Maiworm

Nöth

et al. 2020

Magnetic Resonance Imaging

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Background: In epilepsy patients with focal cortical dysplasia (FCD) as the epileptogenic focus, global cortical signal changes are generally not visible on conventional MRI. However, epileptic seizures or antiepileptic medication might affect normal-appearing cerebral cortex and lead to subtle damage. Purpose: To investigate cortical properties outside FCD regions with T 2-relaxometry. Study Type: Prospective study. Subjects: Sixteen patients with epilepsy and FCD and 16 age-/sex-matched healthy controls. Field Strength/Sequence: 3T, fast spin-echo T 2-mapping, fluid-attenuated inversion recovery (FLAIR), and synthetic T 1weighted magnetization-prepared rapid acquisition of gradient-echoes (MP-RAGE) datasets derived from T 1-maps. Assessment: Reconstruction of the white matter and cortical surfaces based on MP-RAGE structural images was performed to extract cortical T 2 values, excluding lesion areas. Three independent raters confirmed that morphological cortical/juxtacortical changes in the conventional FLAIR datasets outside the FCD areas were definitely absent for all patients. Averaged global cortical T 2 values were compared between groups. Furthermore, group comparisons of regional cortical T 2 values were performed using a surface-based approach. Tests for correlations with clinical parameters were carried out. Statistical Tests: General linear model analysis, permutation simulations, paired and unpaired t-tests, and Pearson correlations. Results: Cortical T 2 values were increased outside FCD regions in patients (83.4 AE 2.1 msec, control group 81.4 AE 2.1 msec, P = 0.01). T 2 increases were widespread, affecting mainly frontal, but also parietal and temporal regions of both hemispheres. Significant correlations were not observed (P ≥ 0.55) between cortical T 2 values in the patient group and the number of seizures in the last 3 months or the number of anticonvulsive drugs in the medical history. Data Conclusion: Widespread increases in cortical T 2 in FCD-associated epilepsy patients were found, suggesting that structural epilepsy in patients with FCD is not only a symptom of a focal cerebral lesion, but also leads to global cortical damage not visible on conventional MRI. Evidence Level: 21 Technical efficacy Stage: 3

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Signatures of life course socioeconomic conditions in brain anatomy

Loued-Khenissi

Trofimova

Vollenweider

et al. 2022

Human Brain Mapping

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Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early‐life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the brain anatomy signatures of SES in a large‐scale population cohort aged 45–85 years. We assess both gray matter morphometry and tissue properties indicative of myelin content. Higher life course SES is associated with increased volume in several brain regions, including postcentral and temporal gyri, cuneus, and cerebellum. We observe more widespread volume differences and higher myelin content in the sensorimotor network but lower myelin content in the temporal lobe associated with childhood SES. Crucially, childhood SES differences persisted in adult brains even after controlling for adult SES, highlighting the unique contribution of early‐life conditions to brain anatomy, independent of later changes in SES. These findings inform on the biological underpinnings of social inequality, particularly as they pertain to early‐life conditions.

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How stable is quantitative MRI? – Assessment of intra- and inter-scanner-model reproducibility using identical acquisition sequences and data analysis programs

Cited by 64 publications

References 43 publications

Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping

Signatures of life course socioeconomic conditions in brain anatomy

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How stable is quantitative MRI? – Assessment of intra- and inter-scanner-model reproducibility using identical acquisition sequences and data analysis programs

Cited by 64 publications

References 43 publications

Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study

Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T2 Mapping

Signatures of life course socioeconomic conditions in brain anatomy

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Product

Resources

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Cortical Changes in Epilepsy Patients With Focal Cortical Dysplasia: New Insights With T₂ Mapping