How should we manage small focal pure ground-glass opacity nodules on high-resolution computed tomography? A single institute experience

Yamaguchi, Masafumi; Furuya, Akio; Edagawa, Makoto; Taguchi, Kenichi; Shimamatsu, Shinichiro; Toyokawa, Gouji; Toyozawa, Ryo; Nosaki, Kaname; Hirai, Fumihiko; Seto, Takashi; Takenoyama, Mitsuhiro; Ichinose, Yukito

doi:10.1016/j.suronc.2015.08.004

Cited by 12 publications

(7 citation statements)

References 28 publications

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“…It is necessary to comprehensively consider imaging changes such as lobulation, burrs, vascular bundle signs, etc. We should consider surgical treatment as early as possible if the size or solid component is gradually increasing during the preoperative follow-up period (13)(14)(15)(16). It was believed that GGO in young patients receiving VATS has a large proportion of malignant, and early surgical intervention for the patients was necessary.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognosis of ground-glass opacity nodules in young patients

Wang¹,

Ma²,

Ni³

et al. 2019

J. Thorac. Dis.

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Background: The detection rate of ground-glass opacity (GGO) in young patients has increased year by year with the increasingly widespread use of high-resolution computed tomography (HRCT) and the increased resolution of HRCT imaging. However, no scholars have reported the clinical characteristics and prognosis of GGO in young patients systematically. The purpose of this study is to investigate the clinical characteristics and prognosis presenting as GGO in young patients. Methods: Clinical data of 127 young patients who were diagnosed as GGO and who underwent videoassisted thoracoscopic surgery (VATS) and had routine pathological examination were collected from January 2016 to January 2017. Nodules were classified according to benign and malignant: 26 benign nodules (Group A) and 115 malignant nodules (Group B). The pathological types, nodules size, surgical methods were analyzed, and the clinical characteristics and prognosis were evaluated. Results: The results of pathological examination of 91 pure ground-glass opacities (pGGOs) revealed 16 adenocarcinoma in situs (AISs), 42 micro invasive adenocarcinomas (MIAs), 13 invasive adenocarcinomas (IAs), 8 atypical adenomatous hyperplasias (AAHs), 1 inflammatory granuloma, 2 pulmonary inflammatory pseudotumors (IPTs) and 9 other benign nodules. The results of pathological examination of 50 mixed ground-glass opacities (mGGOs) revealed 6 AISs, 29 MIAs, 9 IAs, 1 AAH, 2 inflammatory granulomas and 3 other benign nodules. All patients had no lymph nodes invasion. The rates of perioperative complications were 6.30%, compared to 7.63% for long-term complications. None of the patients with GGO experienced a recurrence and death [2-year recurrence-free survival (RFS), 100%; 2-year overall survival (OS), 100%]. Conclusions: The GGO in young patients that received VATS has a high proportion of malignant, its prognosis is satisfied.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognosis of ground-glass opacity nodules in young patients

Wang¹,

Ma²,

Ni³

et al. 2019

J. Thorac. Dis.

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“…This result corresponds with previous studies reporting that the prevalence of MIA or IA ranged from 26 to 82% in surgically resected pure GGNs. [10][11][12][13][14] Taking into consideration the notion that persistent pure GGN is part of a spectrum of lung adenocarcinoma, it is essential to identify preoperative predictors for pathologic invasiveness to decide the optimal timing for interventions (►Fig. 3).…”

Section: Discussionmentioning

confidence: 99%

Lung Adenocarcinoma Invasiveness Risk in Pure Ground-Glass Opacity Lung Nodules Smaller than 2 cm

Lee

Park

et al. 2018

Thorac cardiovasc Surg

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“…First, the JOCG0201 study showed that radiologically defined noninvasive adenocarcinomas 2.0 cm or less with a C/T ratio of 0.25 or less had sensitivity and specificity of 16.2% and 98.7%, respectively, suggesting that histologically invasive adenocarcinomas can present as radiologically noninvasive lesions [6]. For instance, an analysis of pure GGO lesions demonstrated that as many as 8 (19.5%) of 41 pure GGO lesions were invasive adenocarcinomas [23]. Therefore, a slight discrepancy exists between the radiologic and pathologic findings, which should be clarified in future radiologic and pathologic studies.…”

Section: Commentmentioning

confidence: 99%

Relevance Between Programmed Death Ligand 1 and Radiologic Invasiveness in Pathologic Stage I Lung Adenocarcinoma

Toyokawa

Takada

Okamoto

et al. 2017

The Annals of Thoracic Surgery

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How should we manage small focal pure ground-glass opacity nodules on high-resolution computed tomography? A single institute experience

Cited by 12 publications

References 28 publications

Clinical characteristics and prognosis of ground-glass opacity nodules in young patients

Clinical characteristics and prognosis of ground-glass opacity nodules in young patients

Lung Adenocarcinoma Invasiveness Risk in Pure Ground-Glass Opacity Lung Nodules Smaller than 2 cm

Relevance Between Programmed Death Ligand 1 and Radiologic Invasiveness in Pathologic Stage I Lung Adenocarcinoma

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